Neuroprotective Effects of Curcumin in Neurodegenerative Diseases

Foods, Journal Year: 2024, Volume and Issue: 13(11), P. 1774 - 1774

Published: June 5, 2024

Curcumin, a hydrophobic polyphenol extracted from the rhizome of Curcuma longa, is now considered candidate drug for treatment neurological diseases, including Parkinson’s Disease (PD), Alzheimer’s (AD), Huntington’s (HD), Multiple Sclerosis (MS), Amyotrophic Lateral (ALS), and prion disease, due to its potent anti-inflammatory, antioxidant potential, anticancerous, immunomodulatory, neuroprotective, antiproliferative, antibacterial activities. Traditionally, curcumin has been used medicinal dietary purposes in Asia, India, China. However, low water solubility, poor stability blood, high rate metabolism, limited bioavailability, little capability cross blood–brain barrier (BBB) have clinical application curcumin, despite important pharmacological activities this drug. A variety nanocarriers, liposomes, micelles, dendrimers, cubosome nanoparticles, polymer solid lipid nanoparticles developed with great success effectively deliver active brain cells. Functionalization on surface brain-specific ligands makes them target-specific, which should significantly improve bioavailability reduce harmful effects. The aim review summarize studies and/or containing most common neurodegenerative highlighting neuroprotective potential nutraceutical.

Language: Английский

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Nanocurcumin in myocardial infarction therapy: emerging trends and future directions

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 8, 2025

Myocardial infarction (MI) is the leading cause of morbidity and mortality worldwide. Curcumin has been observed to significantly reduce pathological processes associated with MI. Its clinical application limited due its low bioavailability, rapid degradation, poor solubility. Advancements in nanotechnology can be used enhance therapeutic potentials nano-formulation enhances solubility, stability, allowing more precise delivery ischemic cardiac tissue. nanoparticles have successfully infarct size, maintain heart function by modulating essential molecular pathways liposomal formulations provide sustained release higher tissue penetration improved pharmacokinetics enhanced efficacy. Preclinical studies revealed that nanocurcumin drastically lower oxidative stress indicators, inflammatory cytokines, damage. Micelles composed polymers demonstrated high biocompatibility targeting capabilities increased cardio-protective effects. Research trials are for comprehensive analysis efficacy curcumin-based nano-therapeutics cardiovascular condition lowering risk

Language: Английский

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Molecular dynamics in pharmaceutical nanotechnology: simulating interactions and advancing applications

Journal of Biomaterials Science Polymer Edition, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 27

Published: Jan. 9, 2025

Molecular Dynamics (MD) simulations are now widely utilized in pharmaceutical nanotechnology to gain deeper understanding of nanoscale processes imperative drug design. This review has also detailed how MD simulation can be employed the study drug-nanocarrier interactions, controlling release chemical compounds from delivery systems and increasing solubility bioavailability nanocarriers. Furthermore, contributes examining systems, measuring toxic effects, determining biocompatibility nanomedical systems. With incorporation artificial intelligence use hybrid gone a step ahead model other niches biology that make tremendous opening develop highly selective nanomedications. Nevertheless, with well-known issues such as computational constraints discrepancy between silico experiment results, remains work progress, considerable promise for replacing or supplementing existing approaches development precision medicine nanomedicine, continued progression healthcare hopeful.

Language: Английский

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Advancing functional foods: a systematic analysis of plant-derived exosome-like nanoparticles and their health-promoting properties

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: March 5, 2025

Plant-derived exosome-like nanoparticles (PDENs), emerging as novel bioactive agents, exhibit significant potential in food science and nutritional health. These nanoparticles, enriched with plant-specific biomolecules such proteins, lipids, nucleic acids, secondary metabolites, demonstrate unique cross-species regulatory capabilities, enabling interactions mammalian cells gut microbiota. PDENs enhance nutrient bioavailability by protecting sensitive compounds during digestion, modulate metabolic pathways through miRNA-mediated gene regulation, anti-inflammatory antioxidant properties. For instance, grape-derived reduce plasma triglycerides high-fat diets, while ginger-derived alleviate colitis downregulating pro-inflammatory cytokines. Additionally, serve natural drug carriers, applications delivering therapeutic agents like doxorubicin paclitaxel. Despite these advancements, challenges remain standardizing extraction methods (ultracentrifugation, immunoaffinity), ensuring stability processing storage, evaluating long-term safety. Current research highlights the need for optimizing lyophilization techniques understanding between matrices. Furthermore, show promise functional development—such fortified beverages probiotic formulations—their clinical translation requires rigorous pharmacokinetic studies clarity. This review synthesizes existing knowledge on PDENs’ composition, biological activities, applications, identifying gaps scalability, stability, safety assessments. Future directions emphasize interdisciplinary collaboration to harness combating disorders, enhancing functionality, advancing personalized nutrition strategies.

Language: Английский

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Transformative Impact of Nanocarrier‐Mediated Drug Delivery: Overcoming Biological Barriers and Expanding Therapeutic Horizons

Small Science, Journal Year: 2024, Volume and Issue: 4(11)

Published: Sept. 17, 2024

Advancing therapeutic progress is centered on developing drug delivery systems (DDS) that control molecule release, ensuring precise targeting and optimal concentrations. Targeted DDS enhances treatment efficacy minimizes off-target effects, but struggles with degradation. Over the last three decades, nanopharmaceuticals have evolved from laboratory concepts into clinical products, highlighting profound impact of nanotechnology in medicine. Despite advancements, effective therapeutics remains challenging because biological barriers. Nanocarriers offer a solution small size, high surface-to-volume ratios, customizable properties. These address physiological challenges, such as shear stress, protein adsorption, quick clearance. They allow targeted to specific tissues, improve outcomes, reduce adverse effects. exhibit controlled decreased degradation, enhanced efficacy. Their size facilitates cell membrane penetration intracellular delivery. Surface modifications increase affinity for types, allowing This study also elucidates potential integration artificial intelligence nanoscience innovate future nanocarrier systems.

Language: Английский

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Curcumin: A Potential Weapon in the Prevention and Treatment of Head and Neck Cancer

ACS Pharmacology & Translational Science, Journal Year: 2024, Volume and Issue: 7(11), P. 3394 - 3418

Published: Oct. 14, 2024

Head and neck cancers (HNC) are aggressive, difficult-to-treat tumors that can be caused by genetic factors but mainly lifestyle or infection the human papillomavirus. As sixth most common malignancy, it presents a formidable therapeutic challenge with limited modalities. Curcumin, natural polyphenol, is appearing as promising multitarget anticancer antimetastatic agent. Numerous studies have shown curcumin its derivatives potential to affect signaling pathways (NF-κB, JAK/STAT, EGFR) molecular mechanisms crucial for growth migration of head tumors. Furthermore, ability interact tumor microenvironment trigger immune system may significantly influence organism's response tumor. Combining conventional therapies such chemotherapy radiotherapy improve efficacy treatment reduce side effects treatment, thereby increasing potential. This review comprehensive overview discusses both benefits limitations in context biology, an emphasis on HNC. also includes possibilities limiting properties terms development new derivatives, formulations, combinations type therapy HNC subsequent use clinical practice.

Language: Английский

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Transforming cancer treatment: The potential of nanonutraceuticals

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 667, P. 124919 - 124919

Published: Nov. 7, 2024

Language: Английский

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Potential of Natural-Based Sun Protection Factor (SPF): A Systematic Review of Curcumin as Sunscreen

Cosmetics, Journal Year: 2025, Volume and Issue: 12(1), P. 10 - 10

Published: Jan. 15, 2025

Exposure to ultraviolet (UV) radiation from the sun significantly damages skin, leading premature aging, hyperpigmentation, and oxidative stress that disrupts skin homeostasis. UV increases production of reactive oxygen species (ROS), accelerating deterioration. Although sunscreens remain primary method for protection, chemical-based formulations are often associated with side effects, such as allergic reactions acne. To address these concerns, inclusion natural ingredients in sunscreen has gained attention. Curcumin, an active compound found turmeric (Curcuma longa) Java xanthorrhiza), is well-known its antioxidant anti-inflammatory properties. This review explores potential curcumin a ingredient enhancing Sun Protection Factor (SPF) products. A systematic literature was conducted, analyzing 200 articles sourced Google Scholar PubMed using keywords “Curcumin”, “Curcuma”, “Antioxidant”, “Anti-Inflammatory”, “Sun Factor”. Studies unrelated protection were excluded. The findings, presented tabular form, indicate Curcuma exhibit significant enhance SPF values due their antioxidant, anti-inflammatory, UV-absorbing Additionally, may aid repair following UV-induced damage. However, specific concentration various remains unknown, further research necessary determine optimal use. Consideration additional excipients also required maximize efficacy. In conclusion, demonstrates considerable promise sustainable effective protecting radiation, offering safer alternative conventional sunscreens.

Language: Английский

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Physicochemical characteristics of liposomal curcumin immobilized in hybrid alginate/ Alyssum homocarpum seed gum hydrogels by electro-hydrodynamic atomization

Food Hydrocolloids, Journal Year: 2025, Volume and Issue: unknown, P. 111081 - 111081

Published: Jan. 1, 2025

Language: Английский

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Assessment of greenness, blueness, and whiteness profiles of a validated HPLC-DAD method for quantitation of Donepezil HCl and Curcumin in their laboratory prepared co-formulated nanoliposomes

BMC Chemistry, Journal Year: 2025, Volume and Issue: 19(1)

Published: Jan. 18, 2025

Abstract White and Green Analytical Chemistry are innovative approaches in analytical chemistry that prioritize both sustainability efficiency. Together, these aim to advance scientific research while minimizing environmental impact enhancing safety. This integration of consciousness into practices represents a significant step forward achieving sustainable progress. In the present study, sensitive eco-friendly HPLC-DAD method was carried out validated allow concurrent determination Donepezil HCl (DPZ) Curcumin (CUR) their pure form laboratory made nano-liposome formulation. Optimum seperation accomplished by utilising Zobrax Eclipse Plus C18 column (4.6*100 mm,5 μm) with gradient elution mobile phase composed 0.02 M phosphate buffer at pH 3.2 ethanol flow rate 1.5 ml/min. A diode array detector (DAD) implemented for detection 273 nm 435 DPZ CUR, respectively, oven set 40 °C. The according ICH specifications terms accuracy, precision, linearity range, quantification limit. calibration plots were linear correlation coefficients (r2) = 0.999 over range (0.1–100 µg/ml) successively. approach adopted analyse medications prepared nano-liposomal formulation which analytes successfully quantified good recovery values no disrubtion from added excipients. investigation whiteness, blueness, greenness metrics revealed major benefit suggested previous reported ones.

Language: Английский

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