Synthesis of 7,8-dihydroxy-4-phenylbenzo[g]coumarins as potential multitarget anti-skin-aging candidates
Journal of Molecular Structure,
Journal Year:
2024,
Volume and Issue:
1321, P. 139806 - 139806
Published: Aug. 26, 2024
Language: Английский
Advancements in Nanoemulsion-Based Drug Delivery Across Different Administration Routes
Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
17(3), P. 337 - 337
Published: March 5, 2025
Nanoemulsions
(NEs)
have
emerged
as
effective
drug
delivery
systems
over
the
past
few
decades
due
to
their
multifaceted
nature,
offering
advantages
such
enhanced
bioavailability,
protection
of
encapsulated
compounds,
and
low
toxicity.
In
present
review,
we
focus
on
advancements
in
last
five
years
across
(trans)dermal,
oral,
ocular,
nasal,
intra-articular
administration
routes
using
NEs.
Rational
selection
components,
surface
functionalization,
incorporation
permeation
enhancers,
functionalization
with
targeting
moieties
are
explored
for
each
route
discussed.
Additionally,
apart
from
NEs,
explore
NE-based
(e.g.,
gels)
while
highlighting
emerging
approaches
vaccination
theranostic
applications.
The
growing
interest
NEs
purposes
is
reflected
clinical
trials,
which
also
By
summarizing
latest
advances,
exploring
new
strategies,
identifying
critical
challenges,
this
review
focuses
developments
efficient
therapeutic
approaches.
Language: Английский
Development and Evaluation of Anti-Pollution Film-Forming Facial Spray Containing Coffee Cherry Pulp Extract
Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
17(3), P. 360 - 360
Published: March 12, 2025
Background/Objectives:
This
study
aimed
to
develop
and
evaluate
an
anti-pollution
film-forming
spray
(FFS)
containing
coffee
cherry
pulp
extract
(FFS-CCS).
The
formulation
was
designed
create
a
protective
skin
barrier,
improving
health
while
defending
against
environmental
pollutants.
Its
physical
properties,
dust
resistance,
stability,
penetration,
clinical
effectiveness
were
assessed
ensure
optimal
performance
safety.
Methods:
Various
polymers
ternary
solvent
system
used
enhance
the
stability
solubility
of
bioactive
compounds
from
extract.
formulations
characterized
based
on
appearance,
film
formation,
viscosity,
pH,
uniformity,
pattern,
angle,
thickness,
particle
adhesion.
Stability
testing
conducted
under
different
storage
conditions.
Skin
penetration
using
Franz
diffusion
cells
with
Strat-M®
membranes
simulate
human
skin.
A
single-blind,
placebo-controlled
trial
42
participants
over
60
days
effects
FFS-CCS
hydration,
tone,
wrinkle
reduction.
Clinical
assessments
performed
Corneometer,
Mexameter,
Visioscan.
Results:
FFS1-CCS
formulation,
incorporating
PVP
K90
system,
significantly
improved
solubility,
bioavailability
key
(chlorogenic
acid,
caffeine,
theophylline).
Physical
characterization
confirmed
uniform,
transparent
films
viscosity
sprayability.
showed
minimal
degradation.
retention
studies
revealed
enhanced
systemic
absorption.
K90,
along
ethanol
propylene
glycol,
extended
compounds’
residence
time
skin,
ensuring
localized
delivery.
Clinically,
reduced
roughness,
lightened
decreased
erythema.
Conclusions:
utilizing
bioavailability,
extract,
resulting
in
reduction,
tone
enhancement.
These
findings
highlight
potential
as
multifunctional,
sustainable
cosmeceutical
ingredient,
offering
both
anti-aging
protection
benefits,
making
it
promising
solution
for
skincare
applications.
Language: Английский
Functional Performance and Safety Evaluation of Optimized Plant-Based Dye Mixtures for Intense Hair Coloration
Cosmetics,
Journal Year:
2025,
Volume and Issue:
12(2), P. 78 - 78
Published: April 14, 2025
This
study
aimed
to
develop
a
sustainable
and
safe
alternative
chemical
hair
dyes
by
exploring
the
functional
performance
safety
evaluation
of
herbal
mixtures.
Natural
were
extracted
from
Lawsonia
inermis
leaves,
Clitoria
ternatea
flowers,
Indigofera
tinctoria
leaves
using
an
eco-friendly
extraction
method
with
deionized
water
ultrasonication.
The
ratios
these
natural
optimized
statistical
tools,
specifically
Minitab,
determine
most
effective
formulation.
profiles
dyeing
individual
their
combinations
evaluated
focus
on
color
intensity,
stability,
resistance
washing
light
exposure.
optimal
mixture,
ratio
2:2:1:1
(L.
inermis/C.
ternatea/I.
tinctoria/water),
demonstrated
highest
absorbance
lowest
lightness,
indicating
darkest
profile.
When
applied
for
30
min,
this
combination
yielded
long-lasting
intense
dark
color.
Further
testing
hen’s
egg
chorioallantoic
membrane
test
confirmed
favorable
profile,
examination
under
scanning
electron
microscope
showed
no
damage
cuticle,
that
formulation
is
safer
than
dyes.
Therefore,
mixture
promise
as
synthetic
dyes,
further
development
was
suggested.
Language: Английский