Recent advances in nanotechnology for Parkinson’s disease: diagnosis, treatment, and future perspectives

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 22, 2025

Parkinson’s disease is a progressive neurodegenerative that destroys substantia nigra dopaminergic neurons, causing tremors, bradykinesia, rigidity, and postural instability. Current treatment approaches primarily focus on symptom management, employing pharmacological, non-pharmacological, surgical methods. However, these treatments often result in fluctuating symptoms, side effects, progression. Here, the authors have reviewed emerging field of nanomedicine as promising path for treatment, emphasizing its potential to overcome limitations traditional therapies. Nanomedicine utilizes nanoparticles targeted drug delivery, leveraging their small size high surface area volume ratio cross blood-brain barrier deliver therapeutic agents directly affected brain regions. Various nanoparticles, including lipid-based, polymeric, metallic, carbon-based, shown treatment. Additionally, nanocarrier systems like liposomes, nanogels, dendrimers, solid lipid offer controlled sustained release agents, enhancing bioavailability reducing effects. This review provides insights into pathophysiology disease, highlighting mechanisms neurodegeneration, role alpha-synuclein, disruption pathways. It further discusses application gene therapy conjunction with interventions.

Language: Английский

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Review on Cutting-Edge Innovations in Carbon Nanomaterials Reinforced Silicone Rubber Composites for Flexible Electronics and Healthcare Devices

ACS Applied Polymer Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 14, 2024

Silicone rubber has emerged as a versatile material with significant advancements driving its application in flexible electronics and healthcare devices. This review explores the cutting-edge innovations silicone carbon nanomaterials-based composites, emphasizing unique properties that make it suitable for next-generation technology from latest literature survey years 2019–2024. In electronics, rubber's mechanical flexibility, electrical conductivity, thermal stability are highlighted, alongside modern manufacturing techniques such printing technologies layering processes. Key applications including wearable devices, displays, sensors examined their enhanced performance adaptability. realm of healthcare, biocompatibility safety nanomaterial-based composites paramount, enabling use biomedical actuators. delves into heart rate monitors, pressure sensors, drug delivery systems, prosthetics, showcasing material's transformative impact on medical technology. Additionally, integration piezoelectric generators is discussed. Then, revelation synergistic enhance energy harvesting device responsiveness, particularly The also addresses technical market challenges facing broader adoption, offering insights future research directions promise further innovations. underscores critical role shaping these dynamic fields. It provides comprehensive analysis current potential

Language: Английский

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Advancing brain immunotherapy through functional nanomaterials

Drug Delivery and Translational Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 9, 2025

Abstract Glioblastoma (GBM), a highly aggressive brain tumor, poses significant treatment challenges due to its immunosuppressive microenvironment and the immune privilege. Immunotherapy activating system T lymphocyte infiltration holds great promise against GBM. However, brain’s low immunogenicity difficulty of crossing blood-brain barrier (BBB) hinder therapeutic efficacy. Recent advancements in immune-actuated particles for targeted drug delivery have shown potential overcome these obstacles. These interact with BBB by rapidly reversibly disrupting structure, thereby significantly enhancing targeting penetrating delivery. The also minimizes long-term damage. At GBM, demonstrated effective chemotherapy, chemodynamic therapy, photothermal therapy (PTT), photodynamic (PDT), radiotherapy, or magnetotherapy, facilitating tumor disruption promoting antigen release. Additionally, components retained autologous tumor-associated antigens presented them dendritic cells (DCs), ensuring prolonged activation. This review explores mechanisms existing strategies, role nanomaterials immunotherapy. We discuss innovative particle-based approaches designed traverse mimicking innate functions improve outcomes tumors. Graphical

Language: Английский

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Carbon-Based Nanoparticles for Neural Regeneration

Nanotechnology in the life sciences, Journal Year: 2025, Volume and Issue: unknown, P. 263 - 282

Published: Jan. 1, 2025

Language: Английский

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Clinical Applications of Targeted Nanomaterials

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(3), P. 379 - 379

Published: March 17, 2025

Targeted nanomaterials are at the forefront of advancements in nanomedicine due to their unique and versatile properties. These include nanoscale size, shape, surface chemistry, mechanical flexibility, fluorescence, optical behavior, magnetic electronic characteristics, as well biocompatibility biodegradability. attributes enable application across diverse fields, including drug delivery. This review explores fundamental characteristics emphasizes importance clinical applications. It further delves into methodologies for nanoparticle programming alongside discussions on trials case studies. We discussed some promising nanomaterials, such polymeric nanoparticles, carbon-based metallic role biomedical underscores significant translating applications highlights potential these innovative approaches revolutionizing medical field.

Language: Английский

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Light-harvesting pigment-binding protein-mimicking carbon dots for photodynamic therapy

Chinese Chemical Letters, Journal Year: 2025, Volume and Issue: unknown, P. 111133 - 111133

Published: March 1, 2025

Language: Английский

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Advances in nanomedicine and delivery systems for gastric cancer research

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: March 21, 2025

The early diagnosis rate of gastric cancer is low, and most patients are already at an advanced stage by the time they diagnosed, posing significant challenges for treatment exhibiting high recurrence rates, which notably diminish patients’ survival quality life. Therefore, there urgent need to identify methods that can enhance efficacy. Nanomedicine, distinguished its small size, targeting specificity, strong biological compatibility, particularly well-suited address toxic side effects associated with current diagnostic therapeutic approaches cancer. Consequently, application nanomedicine delivery systems in has garnered increasing interest from researchers. This review provides overview recent advancements use nanomaterials as drugs or drug research, encompassing their applications diagnosis, chemotherapy, radiotherapy, surgery, phototherapy, explores promising prospects

Language: Английский

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Innovative Micro- and Nano-Architectures in Biomedical Engineering for Therapeutic and Diagnostic Applications

Micromachines, Journal Year: 2025, Volume and Issue: 16(4), P. 419 - 419

Published: March 31, 2025

The rapid evolution of micro- and nano-architectures is revolutionizing biomedical engineering, particularly in the fields therapeutic diagnostic micromechanics. This review explores recent innovations nanostructured materials their transformative impact on healthcare applications, ranging from drug delivery tissue engineering to biosensing diagnostics. Key advances fabrication techniques, such as lithography, 3D printing, self-assembly, have enabled unprecedented control over material properties functionalities at microscopic scales. These engineered architectures offer enhanced precision targeting controlled release delivery, foster cellular interactions improve sensitivity specificity devices. We examine critical design parameters, including biocompatibility, mechanical resilience, scalability, which influence clinical efficacy long-term stability. also highlights translational potential current limitations bringing these laboratory research practical applications. By providing a comprehensive overview trends, challenges, future perspectives, this article aims inform inspire further development that hold promise for advancing personalized medicine.

Language: Английский

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Role of Nanomedicine in Transforming Pharmacotherapy for Substance Use Disorder (SUD)

Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Journal Year: 2025, Volume and Issue: 17(2)

Published: March 1, 2025

ABSTRACT The field of nanomedicine offers revolutionary potential to reshape the discovery and development therapeutics for diverse human diseases. However, its application has been limited in improving Substance Use Disorders (SUDs), which represent a profound public health crisis, including major types such as opioid, alcohol, stimulant, cannabis use disorders. Pharmacotherapy, cornerstone SUD management, reduced morbidity, mortality, societal impact addiction, though efficacy ranged from none moderate. Thus, there is unmet need transform pharmacotherapy curb epidemic addiction. This article explores roles nanomedicine‐inspired precision‐targeted drug delivery, sustained release, combination therapies increase therapeutic minimize side effects. Additionally, it discusses innovative mechanisms that align with neurobiological complexities addiction synergistic approaches integrate behavioral interventions, device‐based therapies, emerging modalities immunotherapy neurostimulation. Despite these advancements, barriers treatment accessibility, adherence challenges, inequitable resource distribution persist, particularly underserved populations. By harnessing transformative capabilities integrating into holistic, equitable, personalized care frameworks, this review highlights path forward revolutionize landscape. underscores continued nano‐SUD research strategies alleviate substantial burden on individuals, families, society.

Language: Английский

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Potential of Carbon Nanodots (CNDs) in Cancer Treatment

Nanomaterials, Journal Year: 2025, Volume and Issue: 15(7), P. 560 - 560

Published: April 6, 2025

Carbon Nanodots (CNDs) are characterized by their nanoscale size (<10 nm), biocompatibility, stability, fluorescence, and photoluminescence, making them a promising candidate for cancer therapy. The difference in the methods of synthesis CNDs, whether top-down or bottom-up, affects formation, visual, surface characteristics which crucial biomedical pharmaceutical applications. urgent need innovative therapeutic strategies from CNDs is due to limitations barriers posed conventional therapies including drug resistance cytotoxicity. Nano-loaded chemotherapy treatments highly effective can enhance solubility targeted delivery chemotherapeutic agents, generate reactive oxygen species (ROS) induce cell cytotoxicity, regulate intracellular signaling pathways. Their ability be designed cellular uptake exact localization further improves potential. In addition working on delivery, highlighted dual functionality imaging therapy, allows real-time observing treatment efficacy. Despite development these results future, challenges still exist treatment.

Language: Английский

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