Functionalized Niosomes for Co-Delivery of Curcumin and Imatinib Mesylate to Treat Breast Cancer: In Vitro and In Vivo Investigations DOI
Priyadarshi Aparajay, Harishkumar Madhyastha, Mohammad A. Altamimi

et al.

AAPS PharmSciTech, Journal Year: 2025, Volume and Issue: 26(5)

Published: April 29, 2025

Language: Английский

Chitosan and hyaluronic acid in breast cancer treatment: Anticancer efficacy and nanoparticle and hydrogel development DOI
Yanlin Jiang, Yu Cao, Yiqun Yao

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 301, P. 140144 - 140144

Published: Jan. 21, 2025

Language: Английский

Citations

1
Carbohydrate polymer-based nanoparticles in curcumin delivery for cancer therapy: A review DOI
Kexin Meng,

Xintong Tu,

F.W. Sun

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140441 - 140441

Published: Jan. 1, 2025

Language: Английский

Citations

0
Matrix metallopeptidase 2-responsive curcumin-loaded nanoparticles-induced signal transducer and activator of transcription 3 inhibition suppresses glioblastoma multiforme growth via enhancing nuclear factor erythroid 2-related factor 2 activity DOI Creative Commons

Fujie Jia,

Yingpeng Peng,

Xiaobing Li

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 307, P. 141998 - 141998

Published: March 11, 2025

This study investigated the inhibitory effects of matrix metallopeptidase 2 (MMP2)-responsive curcumin-loaded nanoparticles on glioblastoma multiforme (GBM), and elucidated their underlying mechanisms. The methods employed included Cell Counting Kit-8 viability assay, colony formation flow cytometry for apoptosis analysis, wound healing migration quantitative real-time polymerase chain reaction, western blotting gene expression profiling, mitochondrial function assessment, in vivo antitumor efficacy evaluation. Curcumin significantly reduced viability, proliferation, migratory capacity murine glioma cells (GL261). It also induced apoptosis, disrupted function, increased reactive oxygen species levels. Notably, curcumin upregulated nuclear factor erythroid 2-related (Nrf2) while inhibiting signal transducer activator transcription 3 (STAT3) activation. synthesized MMP2-responsive (Cur-NPs) effectively suppressed tumor growth prolonged survival a GBM mouse model. These data suggest that inhibits STAT3 activity via an Nrf2-dependent mechanism. advances our understanding mechanism action suggests potential avenues development targeted therapies GBM.

Language: Английский

Citations

0
Functionalized Niosomes for Co-Delivery of Curcumin and Imatinib Mesylate to Treat Breast Cancer: In Vitro and In Vivo Investigations DOI
Priyadarshi Aparajay, Harishkumar Madhyastha, Mohammad A. Altamimi

et al.

AAPS PharmSciTech, Journal Year: 2025, Volume and Issue: 26(5)

Published: April 29, 2025

Language: Английский

Citations

0