Review of Gold Nanoparticles: Synthesis, Properties, Shapes, Cellular Uptake, Targeting, Release Mechanisms and Applications in Drug Delivery and Therapy

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(10), P. 1332 - 1332

Published: Oct. 16, 2024

The remarkable versatility of gold nanoparticles (AuNPs) makes them innovative agents across various fields, including drug delivery, biosensing, catalysis, bioimaging, and vaccine development. This paper provides a detailed review the important role AuNPs in delivery therapeutics. We begin by exploring traditional systems (DDS), highlighting revolutionizing techniques. then describe unique intriguing properties that make exceptional for delivery. Their shapes, functionalization, drug-loading bonds, targeting mechanisms, release therapeutic effects, cellular uptake methods are discussed, along with relevant examples from literature. Lastly, we present applications medical domains, cancer, cardiovascular diseases, ocular diabetes, focus on vitro vivo cancer research.

Language: Английский

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Last Fifteen Years of Nanotechnology Application with Our Contribute

Nanomaterials, Journal Year: 2025, Volume and Issue: 15(4), P. 265 - 265

Published: Feb. 10, 2025

Currently, nanotechnology is the most promising science, engineering, and technology conducted at nanoscale (nm), which used in several sectors. Collectively, causing a new industrial revolution, nano-based products are becoming increasingly important for global market economy. The interest nanomaterials has been strongly augmented during last two decades, this fact can be easily evaluated by considering number of studies present literature. In November 2024, they accounted 764,279 experimental developed years 2009–2024. During such period, our group contributed to field applicative with review articles, we hope could have relevantly enhanced knowledge scientific community. publication, an exhaustive overview regarding main types nanomaterials, characterization techniques, their applications discussed. Particular attention paid employed enhancement bioavailability delivery bioactive molecules those ameliorating traditional food packaging. Then, briefly reviewed on development nanoparticles (NPs), dendrimers, micelles, liposomes biomedical collecting inherent details reader-friendly table. A brief excursus about reviews topic also provided, followed stinging question nanotoxicology. Indeed, although application translates into great improvement properties non-nanosized pristine materials, there may still not totally predictable risk humans, animals, environment associated extensive NPs. Nanotoxicology science rapid expansion, but sneaky risks yet fully disclosed. So, final part study discusses pending issue related possible toxic effects NPs impact customers’ acceptance scenario limited knowledge.

Language: Английский

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Iron Homeostasis-Regulated Adaptive Metabolism of PEGylated Ultrasmall Iron Oxide Nanoparticles

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

Iron oxide nanoparticles have become increasingly significant in the biomedical field due to their exceptional magnetic properties and biocompatibility. However, understanding vivo metabolism transformation is crucial potential biological effects they may induce. This study investigates metabolic pathways of PEGylated ultrasmall iron (PUSIONPs) vivo, particularly under varying statuses dosages. Employing a comprehensive analytical approach─including resonance imaging, elemental analysis, histological assessments, hematological Western blot analysis─the biodistribution PUSIONPs were mapped. The findings reveal differences fate between iron-sufficient iron-deficient conditions, underscoring pivotal role homeostasis regulating biodegradation. In states, degradation markedly accelerated, with released rapidly incorporated into hemoglobin. Additionally, liver spleen exhibited different rates distinct physiological roles: spleen, primarily responsible for recycling, facilitated faster degradation, while liver, serving as an storage organ, showed slower degradation. Under deficiency, most products directed toward hemoglobin synthesis, whereas normal gradually metabolized products, retained higher levels. Moreover, demonstrated dose dependency, doses slowing reducing utilization rate by body. Comprehensive safety evaluations confirmed that exhibit excellent biocompatibility across all doses, no concerns. Compared clinically used intravenous supplement sucrose, also superior bioavailability more effective supplementation. These provide critical insights interaction metabolism, offering foundation future research broader application contexts.

Language: Английский

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Nano-priming of seeds with derived γFe2O3 Nanoparticles

Biocatalysis and Agricultural Biotechnology, Journal Year: 2024, Volume and Issue: 62, P. 103428 - 103428

Published: Nov. 2, 2024

Language: Английский

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