Microenvironment-adaptive nanomedicine MXene promotes flap survival by inhibiting ROS cascade and endothelial pyroptosis DOI Creative Commons
Ningning Yang, Rongrong Hua, Yingying Lai

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: April 7, 2025

In the field of large-area trauma flap transplantation, preventing avascular necrosis remains a critical challenge. Key mechanisms for improving viability include angiogenesis promotion, oxidative stress inhibition, and cell death prevention. Recently, two-dimensional ultrathin Ti3C2TX (MXene) nanosheets have gained attention their potential contributions to these processes, though MXene's physiological impact on survival had not been previously investigated. This study is first confirm biological effects ischaemic microenvironment post-skin transplantation. Findings indicated that MXene significantly decreased necrotic area in flaps (37.96% ± 2.00%), with reductions 30.40% 1.86% at 1 mg/mL 20.19% 2.11% 2 concentration-dependent manner. Mechanistically, facilitated situ angiogenesis, mitigated stress, suppressed pro-inflammatory pyroptosis, activated PI3K-Akt pathway, particularly influencing vascular endothelial cells. Comparative transcriptome analysis skin tissues without treatment provided additional evidence, highlighting such as ROS metabolic proliferation regulation, signaling pathway activation. Overall, demonstrated activity, effectively promoting presenting novel strategy addressing flaps.

Language: Английский

Application and progress of smart hydrogel microspheres for regulating oxidative stress in osteoarthritis DOI
Jinping Chen, Chengcheng Du, Bin Tang

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160620 - 160620

Published: Feb. 1, 2025

Language: Английский

Citations

1
Microenvironment-adaptive nanomedicine MXene promotes flap survival by inhibiting ROS cascade and endothelial pyroptosis DOI Creative Commons
Ningning Yang, Rongrong Hua, Yingying Lai

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: April 7, 2025

In the field of large-area trauma flap transplantation, preventing avascular necrosis remains a critical challenge. Key mechanisms for improving viability include angiogenesis promotion, oxidative stress inhibition, and cell death prevention. Recently, two-dimensional ultrathin Ti3C2TX (MXene) nanosheets have gained attention their potential contributions to these processes, though MXene's physiological impact on survival had not been previously investigated. This study is first confirm biological effects ischaemic microenvironment post-skin transplantation. Findings indicated that MXene significantly decreased necrotic area in flaps (37.96% ± 2.00%), with reductions 30.40% 1.86% at 1 mg/mL 20.19% 2.11% 2 concentration-dependent manner. Mechanistically, facilitated situ angiogenesis, mitigated stress, suppressed pro-inflammatory pyroptosis, activated PI3K-Akt pathway, particularly influencing vascular endothelial cells. Comparative transcriptome analysis skin tissues without treatment provided additional evidence, highlighting such as ROS metabolic proliferation regulation, signaling pathway activation. Overall, demonstrated activity, effectively promoting presenting novel strategy addressing flaps.

Language: Английский

Citations

0