Standardization of Ag: DNA Base-Pair Ratio for Optimum Fluorescence DOI
Hector Henry Oyem

Published: Jan. 1, 2024

Language: Английский

A Comprehensive Review of Nanoparticle-Based Drug Delivery for Modulating PI3K/AKT/mTOR-Mediated Autophagy in Cancer DOI Open Access
Md. Ataur Rahman, Maroua Jalouli,

Sujay Kumar Bhajan

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 1868 - 1868

Published: Feb. 21, 2025

The phosphoinositide 3-kinase (PI3K)/AKT/mammalian target of the rapamycin (mTOR) pathway plays a crucial role in regulation autophagy, cellular mechanism vital for homeostasis through degradation damaged organelles and proteins. dysregulation this is significantly associated with cancer progression, metastasis, resistance to therapy. Targeting PI3K/AKT/mTOR signaling presents promising strategy treatment; however, traditional therapeutics frequently encounter issues related nonspecific distribution systemic toxicity. Nanoparticle-based drug delivery systems represent significant advancement addressing these limitations. Nanoparticles enhance bioavailability, stability, targeted therapeutic agents, facilitating precise modulation autophagy cells. Functionalized nanoparticles, such as liposomes, polymeric metal-based nanocarriers, facilitate tumor tissues, minimizing off-target effects improving efficacy. These can deliver multiple agents concurrently, enhancing PI3K/AKT/mTOR-mediated oncogenic pathways. This review examines advancements nanoparticle-mediated that pathway, emphasizing their contribution precision side integration nanotechnology molecularly therapies substantial potential resistance. Future initiatives must prioritize optimization clinical translation patient outcomes.

Language: Английский

Citations

1
Visualizing In Situ Nucleation and Growth Dynamics of CdSe-Based Heterostructures Regulated by the Water/Oil-Phase Microenvironment DOI
Simin Peng, Linfeng Xu,

Zetan Cao

et al.

Nano Letters, Journal Year: 2025, Volume and Issue: 25(9), P. 3662 - 3669

Published: Feb. 22, 2025

Wet-chemical reactions, covering almost all solution-based synthesis in either the oil-phase or water-phase microenvironment, lead to as-formed products with distinct morphologies, structures, and functionalities. However, crystal nucleation growth dynamics under those microenvironments for same material system have not been clarified. Using situ transmission electron microscopy on classical II-VI CdSe-based heterostructures atomic scale resolution, notably, we revealed formation of Au CdSe surface oil phase while AuSe product was nucleated water phase. The analogous two-step amorphous-to-crystalline transition, followed by coalescence into polycrystalline nanoparticles. During ex growth, majority (∼79%) phase, contrast ∼52% Surprisingly, proportion single crystals prevailed, which significantly increased ∼76% case. Such behaviors were further verified through liquid-cell environment elemental characterizations.

Language: Английский

Citations

0
Tuning surface assembly of oleyl-capped nanoparticles in AOT microemulsion phase with optimal alkane-to-alkanol ratio DOI
Rebeca Fortes Martín,

Sibylle Rüstig,

Ilko Bald

et al.

Colloids and Interface Science Communications, Journal Year: 2025, Volume and Issue: 66, P. 100836 - 100836

Published: April 9, 2025

Language: Английский

Citations

0
Standardisation of Ag: DNA Base-Pairs Ratio for Optimum Fluorescence DOI
Hector Henry Oyem

Published: Jan. 1, 2024

Language: Английский

Citations

0
Standardization of Ag: DNA Base-Pair Ratio for Optimum Fluorescence DOI
Hector Henry Oyem

Published: Jan. 1, 2024

Language: Английский

Citations

0