Antimicrobial Coatings Based on Hybrid Iron Oxide Nanoparticles DOI Creative Commons

Doina-Antonia Mercan,

Dana-Ionela Tudorache,

Adelina-Gabriela Niculescu

et al.

Nanomaterials, Journal Year: 2025, Volume and Issue: 15(9), P. 637 - 637

Published: April 22, 2025

This study presents the preparation of hybrid iron oxide nanocomposites through a two-step process combining microfluidic-assisted synthesis and post-synthetic surface modification. Fe3O4 nanoparticles were synthesized simultaneously functionalized with salicylic acid using three-dimensional vortex-type microfluidic chip, enabling rapid uniform particle formation. The resulting Fe3O4/SA nanostructures further modified either silver or copper to form enhanced antimicrobial functionality. These subsequently integrated into silica aerogel matrices dip-coating approach improve dispersion, structural stability, biocompatibility. morphological properties samples investigated XRD, FT-IR, TEM SAED analysis, Raman microscopy. In vitro cytotoxicity assays demonstrated that Fe3O4/SA–Ag Fe3O4/SA–CuO exhibit potent antibacterial activity cell type-dependent vivo biodistribution studies showed no accumulation in major organs selective clearance via spleen, validating systemic safety platform. findings highlight potential as biocompatible, coatings for advanced biomedical surfaces.

Language: Английский

Nanomaterial-Based Strategies to Combat Antibiotic Resistance: Mechanisms and Applications DOI Creative Commons
Nargish Parvin, Sang Woo Joo, Tapas Kumar Mandal

et al.

Antibiotics, Journal Year: 2025, Volume and Issue: 14(2), P. 207 - 207

Published: Feb. 18, 2025

The rapid rise of antibiotic resistance has become a global health crisis, necessitating the development innovative strategies to combat multidrug-resistant (MDR) pathogens. Nanomaterials have emerged as promising tools in this fight, offering unique physicochemical properties that enhance efficacy, overcome mechanisms, and provide alternative therapeutic approaches. This review explores diverse nanomaterial-based used resistance, focusing on their mechanisms action practical applications. such metal nanoparticles, carbon-based nanomaterials, polymeric nanostructures exhibit antibacterial through various pathways, including generation reactive oxygen species (ROS), disruption bacterial membranes, enhancement delivery. Additionally, ability nanomaterials bypass traditional biofilm formation efflux pumps, been demonstrated numerous studies. also discusses synergistic effects observed when are combined with conventional antibiotics, leading increased susceptibility reduced required dosages. By highlighting recent advancements clinical applications nanomaterial-antibiotic combinations, paper provides comprehensive overview how reshaping future therapies. Future research directions challenges, toxicity scalability, addressed guide safer, more effective treatments.

Language: Английский

Citations

3
Selection and applications of electrocatalysts for electrochemical anodizing oxidation of emerging contaminants in water: A review DOI
Jia Wang,

Yihang Hu,

Tao Cao

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 159620 - 159620

Published: Jan. 1, 2025

Language: Английский

Citations

0
Antimicrobial Coatings Based on Hybrid Iron Oxide Nanoparticles DOI Creative Commons

Doina-Antonia Mercan,

Dana-Ionela Tudorache,

Adelina-Gabriela Niculescu

et al.

Nanomaterials, Journal Year: 2025, Volume and Issue: 15(9), P. 637 - 637

Published: April 22, 2025

This study presents the preparation of hybrid iron oxide nanocomposites through a two-step process combining microfluidic-assisted synthesis and post-synthetic surface modification. Fe3O4 nanoparticles were synthesized simultaneously functionalized with salicylic acid using three-dimensional vortex-type microfluidic chip, enabling rapid uniform particle formation. The resulting Fe3O4/SA nanostructures further modified either silver or copper to form enhanced antimicrobial functionality. These subsequently integrated into silica aerogel matrices dip-coating approach improve dispersion, structural stability, biocompatibility. morphological properties samples investigated XRD, FT-IR, TEM SAED analysis, Raman microscopy. In vitro cytotoxicity assays demonstrated that Fe3O4/SA–Ag Fe3O4/SA–CuO exhibit potent antibacterial activity cell type-dependent vivo biodistribution studies showed no accumulation in major organs selective clearance via spleen, validating systemic safety platform. findings highlight potential as biocompatible, coatings for advanced biomedical surfaces.

Language: Английский

Citations

0