Colloids and Surfaces A Physicochemical and Engineering Aspects, Journal Year: 2025, Volume and Issue: unknown, P. 137201 - 137201
Published: May 1, 2025
Language: Английский
Food Engineering Reviews, Journal Year: 2025, Volume and Issue: unknown
Published: March 25, 2025
Language: Английский
Citations
2
Macromol—A Journal of Macromolecular Research, Journal Year: 2025, Volume and Issue: 5(2), P. 15 - 15
Published: April 8, 2025
Antimicrobial resistance (AMR) is a major global health problem, exacerbated by the excessive and inappropriate use of antibiotics in human medicine, animal care agriculture. Therefore, new strategies compounds are needed to overcome this issue. In view, it may be appropriate reconsider existing biomaterials alleviate antibiotic overuse. Chitin, naturally abundant amino mucopolysaccharide, poly-β-1, 4-N-acetylglucosamine (GlcNAc). It white, hard, inelastic, nitrogenous polysaccharide source surface pollution coastal areas. Chitosan derives from partial N-deacetylation chitin originates shells crustaceans fungi cell walls. nontoxic natural antimicrobial polymer approved GRAS (Generally Recognized as Safe United States Food Drug Administration). Chitin chitosan, non-toxic biopolymers, useful for wastewater treatment remove pollutants, such pharmaceuticals, heavy metals dyes. The described features make these biopolymers intriguing investigated their application antibacterials.
Language: Английский
Citations
0
Toxins, Journal Year: 2025, Volume and Issue: 17(5), P. 221 - 221
Published: May 1, 2025
The occurrence of antibiotic-resistant bacteria is a serious global health issue, and it emphasizes the need for novel antimicrobial agents. This review explores potential snake venom as another alternative strategy against resistance. Snake venoms are complex combinations bioactive peptides proteins, including metalloproteases (MPs), serine proteases (SPs), phospholipase A2 (PLA2) enzymes, three-finger toxins (3FTXs), cysteine-rich secretory proteins (CRISPs), L-amino acid oxidases (LAAOs), (AMPs). antibacterial products possess wide-spectrum activity resistant microbes via diverse mechanisms such cell membrane disruption, enzymatic hydrolysis microbial structures, generation oxidative stress, inhibition biofilms, immunomodulation. Strong reported by most studies, but these mostly restricted to in vitro testing with low translational use. Although preliminary insights into molecular targets physiological effects exist, further studies needed clarify long-term safety therapeutic potential. Special attention given venom-derived extracellular vesicles (SVEVs), which enhance protecting them from degradation, improving bioavailability, facilitating targeted delivery. Furthermore, innovative delivery strategies PEGylation, liposomes, hydrogels, microneedle patches, biopolymer films, nanoparticles discussed their role reducing systemic toxicity enhancing efficacy. rational modification expands utility pharmacokinetics minimizing off-target effects. Together, approaches highlight venom-based therapies next-generation antimicrobials fight infections. By outlining challenges directions, this positions an overlooked fertile resource battle antibiotic
Language: Английский
Citations
0
Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: 362, P. 123691 - 123691
Published: May 2, 2025
Language: Английский
Citations
0
ACS Omega, Journal Year: 2025, Volume and Issue: unknown
Published: May 15, 2025
Language: Английский
Citations
0
Colloids and Surfaces A Physicochemical and Engineering Aspects, Journal Year: 2025, Volume and Issue: unknown, P. 137201 - 137201
Published: May 1, 2025
Language: Английский
Citations
0