Doxorubicin and NFL-TBS.40-63 peptide loaded gold nanoparticles as a multimodal therapy of glioblastoma DOI Creative Commons

Myriam El Moutaoukil,

Maria Grazia Lolli,

Stefania D’Amone

et al.

Discover Nano, Journal Year: 2025, Volume and Issue: 20(1)

Published: April 28, 2025

Conventional treatments for glioblastoma (GBM) are hindered by systemic toxicity, limited blood-brain barrier penetration, and therapeutic resistance. To address these challenges, we developed dual-functionalized gold nanoparticles (AuNPs) conjugated with a biotinylated NFL-TBS.40-63 peptide the chemotherapeutic agent doxorubicin. This platform integrates targeted delivery action to enhance efficacy while minimising off-target effects. Our findings reveal superior cellular uptake, dose- time-dependent cytotoxicity, apoptosis induction in GBM cells compared mono-functionalized counterparts. Furthermore, pH-sensitive drug release profiles underscore system's potential exploit tumour microenvironment's acidic conditions precise delivery. Comprehensive characterisation confirmed stability, biocompatibility, functional of AuNPs. study highlights promise nanoconjugates as multimodal approach therapy, paving way further translational research nanomedicine.

Language: Английский

Recent doxorubicin-conjugates in cancer drug delivery: Exploring conjugation strategies for enhanced efficacy and reduced toxicity DOI

Shreastha Gautam,

Sachin Joshi,

Priya Jindal

et al.

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125556 - 125556

Published: April 1, 2025

Language: Английский

Citations

0
Advances in Targeted Delivery of Doxorubicin for Cancer Chemotherapy DOI Creative Commons

Wenhui Xia,

Martin W. King

Bioengineering, Journal Year: 2025, Volume and Issue: 12(4), P. 430 - 430

Published: April 19, 2025

Doxorubicin (DOX) is one of the most powerful chemotherapy drugs used to treat different kinds cancer. However, its usage has been limited by typical side effects and drug resistance, particularly cardiotoxicity. According studies, a more effective promising method conjugate it or entrap in biocompatible nanoparticles. Compared free DOX traditional formulations, nanoparticles using specific processes techniques can improve stability, minimize premature release at untargeted locations, lower systemic toxicity. This review explains how various nanocarriers target tumor therapeutic efficacy while reducing negative DOX.

Language: Английский

Citations

0
Doxorubicin and NFL-TBS.40-63 peptide loaded gold nanoparticles as a multimodal therapy of glioblastoma DOI Creative Commons

Myriam El Moutaoukil,

Maria Grazia Lolli,

Stefania D’Amone

et al.

Discover Nano, Journal Year: 2025, Volume and Issue: 20(1)

Published: April 28, 2025

Conventional treatments for glioblastoma (GBM) are hindered by systemic toxicity, limited blood-brain barrier penetration, and therapeutic resistance. To address these challenges, we developed dual-functionalized gold nanoparticles (AuNPs) conjugated with a biotinylated NFL-TBS.40-63 peptide the chemotherapeutic agent doxorubicin. This platform integrates targeted delivery action to enhance efficacy while minimising off-target effects. Our findings reveal superior cellular uptake, dose- time-dependent cytotoxicity, apoptosis induction in GBM cells compared mono-functionalized counterparts. Furthermore, pH-sensitive drug release profiles underscore system's potential exploit tumour microenvironment's acidic conditions precise delivery. Comprehensive characterisation confirmed stability, biocompatibility, functional of AuNPs. study highlights promise nanoconjugates as multimodal approach therapy, paving way further translational research nanomedicine.

Language: Английский

Citations

0