Silver Nanoparticle-Induced Nephrotoxicity in Zebrafish (Danio rerio)

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(9), P. 4216 - 4216

Published: April 29, 2025

The escalating challenge of antibacterial resistance has driven the widespread use silver nanoparticles (AgNPs) due to their potent antimicrobial properties. AgNPs can be synthesised through diverse methods, spanning conventional chemical and physical routes increasingly favoured biosynthesis approach. While offering environmental advantages, ecological impact biogenically synthesized AgNPs, especially on aquatic ecosystems, requires thorough evaluation. renal system, critical for maintaining physiological homeostasis via nephron-mediated waste removal, fluid regulation, electrolyte balance, is highly vulnerable toxicant-induced damage, which negatively affect organismal fitness. This study aimed assess nephrotoxic effects using entirely “green” zebrafish after 96-h exposures three distinct concentrations alongside a control group. Acridine orange fluorescence microscopy revealed dose-dependent histopathological alterations in tissues. Specifically, at 0.031 μg/L 0.250 μg/L, significant changes were observed, including glomerular shrinkage, proliferation hematopoietic tissue, dissociation dilation tubules, melanomacrophage aggregation. At 5.000 prolonged exposure beyond 48 h indicated potential tissue cell renewal, suggesting possible compensatory response. These results demonstrate sensitivity kidneys emphasize imperative comprehensive vivo toxicity testing, irrespective synthesis method, accurately evaluate adverse impacts ensure preservation ecosystem integrity.

Language: Английский

Silver Nanoparticles: A Versatile Tool Against Infectious and Non-Infectious Diseases

Antibiotics, Journal Year: 2025, Volume and Issue: 14(3), P. 289 - 289

Published: March 11, 2025

Silver nanoparticles possess remarkable properties that render them highly beneficial for medical applications in both infectious and non-infectious diseases. Among their most renowned attributes is antimicrobial activity. They have demonstrated efficacy against a wide range of bacteria, fungi, protozoa, viruses. Additionally, the antitumor anti-diabetic silver nanoparticles, along with ability to promote wound healing application as biosensors, underscore therapeutic potential various conditions. As are employed purposes, toxicity must be considered. While present promising alternative domain, further research needed elucidate precise mechanisms action, optimize efficacy, mitigate any health risks associated use.

Language: Английский

Green synthesis of Ananas comosus (L.) Merr. based-silver nanoparticles and determination of their potential in electrochemical detection of H2O2

Biomass Conversion and Biorefinery, Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

Language: Английский