Exploratory Review and In Silico Insights into circRNA and RNA-Binding Protein Roles in γ-Globin to β-Globin Switching DOI Creative Commons
Alawi Habara

Cells, Journal Year: 2025, Volume and Issue: 14(4), P. 312 - 312

Published: Feb. 19, 2025

β-globin gene cluster regulation involves complex mechanisms to ensure proper expression and function in RBCs. During development, switching occurs as γ-globin is replaced by β-globin. Key regulators, like BCL11A ZBTB7A, repress facilitate this transition with other factors, KLF1, LSD1, PGC-1α; these regulators an orchestrated from γ- during development. While have been extensively studied, circRNAs recently emerged key contributors regulation, but their role remains largely unexplored. Although discovered the 1970s, only recognized for functional roles, particularly interactions RNA-binding proteins. Understanding how contribute could lead new therapeutic strategies hemoglobinopathies, such sickle cell disease β-thalassemia. This review uses circAtlas 3.0 database explore circRNA expressions genes related expression, focusing on blood, bone marrow, liver, spleen. It emphasizes exploration of potential between proteins involved regulatory mechanisms, further enhancing our understanding expression.

Language: Английский

Exploratory Review and In Silico Insights into circRNA and RNA-Binding Protein Roles in γ-Globin to β-Globin Switching DOI Creative Commons
Alawi Habara

Cells, Journal Year: 2025, Volume and Issue: 14(4), P. 312 - 312

Published: Feb. 19, 2025

β-globin gene cluster regulation involves complex mechanisms to ensure proper expression and function in RBCs. During development, switching occurs as γ-globin is replaced by β-globin. Key regulators, like BCL11A ZBTB7A, repress facilitate this transition with other factors, KLF1, LSD1, PGC-1α; these regulators an orchestrated from γ- during development. While have been extensively studied, circRNAs recently emerged key contributors regulation, but their role remains largely unexplored. Although discovered the 1970s, only recognized for functional roles, particularly interactions RNA-binding proteins. Understanding how contribute could lead new therapeutic strategies hemoglobinopathies, such sickle cell disease β-thalassemia. This review uses circAtlas 3.0 database explore circRNA expressions genes related expression, focusing on blood, bone marrow, liver, spleen. It emphasizes exploration of potential between proteins involved regulatory mechanisms, further enhancing our understanding expression.

Language: Английский

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