International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(24), P. 13603 - 13603
Published: Dec. 19, 2024
Pulpitis,
an
inflammation
of
the
dental
pulp,
is
generated
by
bacterial
invasion
through
different
ways
as
caries.
In
establishment
and
development
this
disease,
biological
processes
are
involved.
Long
non-coding
RNAs
(lncRNAs)
circular
(circRNAs)
transcripts
with
regulatory
capacity
participating
in
functions
have
been
implicated
diseases.
The
aim
narrative
review
to
critically
analyze
available
evidence
on
role
lncRNAs
circRNAs
pulpitis
discuss
possible
new
research
prospects.
LncRNAs
involved
were
explored,
addressing
their
expression,
molecular
mechanisms,
targets
effects
studied
animal
vitro
models,
well
studies
human
patients.
emerging
key
regulators
diverse
including
apoptosis,
proliferation,
differentiation,
oxidative
stress,
autophagy,
ferroptosis,
immune
response.
mechanisms
performed
these
(ncRNAs)
interactions
miRNAs
formation
networks
context
pulpitis.
Further
more
deeply
analyzing
participation
will
reveal
potential
applications
ncRNAs
biomarkers
or
use
therapeutic
strategies
pulp
inflammation.
Cells,
Journal Year:
2025,
Volume and Issue:
14(4), P. 283 - 283
Published: Feb. 14, 2025
The
immune
system
must
carefully
balance
fighting
pathogens
with
minimization
of
inflammation
and
avoidance
autoimmune
responses.
Over
the
past
ten
years,
researchers
have
extensively
studied
mechanisms
regulating
this
delicate
balance.
Comprehending
these
is
essential
for
developing
treatments
inflammatory
conditions.
This
review
aims
to
synthesize
knowledge
immunoregulatory
processes
published
from
2014-2024
highlight
discoveries
that
provide
fresh
perspectives
on
complex
keywords
"molecular
mechanisms",
"immune
regulation",
signaling
pathways",
homeostasis"
were
used
search
PubMed
articles
between
2014
2024,
a
preference
in
three
years.
Recent
research
has
pinpointed
impact
factors
such
as
cytokine
signaling,
T-cell
regulation,
epigenetic
immunometabolism
function.
New
highlights
intricate
interactions
other
molecular
elements.
A
key
area
interest
non-coding
RNAs
metabolic
pathways
regulation
Exploring
by
which
regulated
will
new
avenues
address
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(9), P. 4413 - 4413
Published: May 6, 2025
Long,
non-coding
RNAs
(lncRNAs)
are
a
class
of
exceeding
200
nucleotides
in
length,
lacking
the
ability
to
be
translated
into
proteins.
Over
past
few
decades,
an
increasing
number
publications
have
established
lncRNAs
as
potent
regulators
broad
spectrum
diseases.
They
modulate
expression
critical
genes
by
affecting
transcription,
post-transcription,
translation,
and
protein
modification.
This
regulation
frequently
involves
interaction
with
various
molecules,
such
proteins,
RNA,
DNA.
involved
diseases
where
stress
is
significant
factor.
In
recent
years,
been
identified
both
innate
adaptive
immune
responses,
playing
roles
onset
progression
Additionally,
hold
potential
biomarkers
or
therapeutic
targets
for
numerous
stress-
immune-related
lncRNA
nuclear-enriched
abundant
transcript
1
(NEAT1)
notable
example.
review
consolidates
latest
findings
about
role
NEAT1
response
cell
function
non-cancer
It
summarizes
studies
on
regulating
response,
immunity,
its
biomarker
target
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(10), P. 4821 - 4821
Published: May 17, 2025
Long
non-coding
RNAs
(lncRNAs)
have
emerged
as
pivotal
regulators
of
the
dynamic
interplay
between
cancer
progression
and
immune
responses.
This
review
explored
their
influence
on
key
processes
cancer–immunity
cycle,
such
cell
differentiation,
antigen
presentation,
tumor
immunogenicity.
By
modulating
escape
from
response,
therapeutic
resistance,
tumor–stroma
interactions,
lncRNAs
actively
shape
microenvironment.
Due
to
growing
knowledge
in
area
suppression,
directly
intervening
induction
regulatory
T
cells
(Tregs),
M2
macrophages,
regulating
checkpoint
pathways
PD-L1,
CTLA-4,
others,
can
be
considered
promising
targets.
Advances
single-cell
technologies
immunotherapy
significantly
expanded
our
understanding
lncRNA-driven
networks,
paving
way
for
novel
precision
medicine
approaches.
Ultimately,
we
discussed
how
targeting
could
enhance
immunotherapy,
offering
new
avenues
biomarker
discovery
intervention.
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: Aug. 27, 2024
Cancer
treatment
has
long
been
fraught
with
challenges,
including
drug
resistance,
metastasis,
and
recurrence,
making
it
one
of
the
most
difficult
diseases
to
treat
effectively.
Traditional
therapeutic
approaches
often
fall
short
due
their
inability
target
cancer
stem
cells
complex
genetic
epigenetic
landscape
tumors.
In
recent
years,
immunotherapy
revolutionized
field,
offering
new
hope
viable
alternatives
conventional
treatments.
A
particularly
promising
area
research
focuses
on
non-coding
RNAs
(ncRNAs),
especially
(lncRNAs),
role
in
resistance
modulation
signaling
pathways.
To
address
these
we
performed
a
comprehensive
review
studies
lncRNAs
impact
immunotherapy.
Our
highlights
crucial
roles
that
play
affecting
both
innate
adaptive
immunity,
thereby
influencing
outcomes
Key
observations
from
our
indicate
can
modify
tumor
immune
microenvironment,
enhance
cell
infiltration,
regulate
cytokine
production,
all
which
contribute
growth
therapies.
These
insights
suggest
could
serve
as
potential
targets
for
precision
medicine,
opening
up
avenues
developing
more
effective
immunotherapies.
By
compiling
across
various
cancers,
this
aims
shed
light
mechanisms
within
microenvironment.
