Revista Médica de Trujillo,
Journal Year:
2022,
Volume and Issue:
17(3), P. 103 - 107
Published: Sept. 30, 2022
Antipsychotics
are
increasingly
prescribed
for
various
disorders
including
bipolar
disorder,
schizophrenia,
other
psychotic
and
to
a
lesser
extent
depression,
anxiety,
insomnia
even
nausea
during
pregnancy.
The
full
knowledge
about
its
possible
effects
due
exposure
pregnancy
is
still
limited,
although
some
studies
refer
degree
of
relationship
with
the
appearance
such
as
gestational
diabetes,
premature
birth,
congenital
malformations,
our
review
did
not
find
sufficiently
clear
them.
In
addition
safety
profile,
another
aspect
consider
assessment
that
untreated
psychiatric
could
also
represent
risk
factor
poor
outcomes.
Therefore,
lack
highly
significant
data
on
these
aspects
pregnancy,
more
needed
provide
detail
risks
benefits
drugs
at
this
stage.
Advanced Emergency Nursing Journal,
Journal Year:
2023,
Volume and Issue:
45(4), P. 301 - 310
Published: Oct. 1, 2023
New
onset
of
agitation
during
pregnancy
is
an
obstetric
and
behavioral
emergency
that
demands
careful
evaluation
prompt
treatment.
This
article
provides
overview
clinical
types
nonpharmacologic
pharmacologic
interventions
when
managing
acute
pregnancy.
Rapid
management
are
keys
to
preventing
detrimental
maternal
fetal
complications.
Clinicians
must
seek
out
medical
etiologies
always
attempt
verbal
de-escalation
before
initiating
chemical
or
physical
restraints.
Should
medication
be
necessary,
first-generation
antipsychotics,
second-generation
antihistamines,
benzodiazepines
may
considered.
Managing
in
a
challenging
dilemma
due
the
fear
adverse
neonatal
outcomes
as
well
legal
risk
involved.
Nevertheless,
clinicians
should
continue
assess
patient
without
delay,
differentiate
underlying
causes
agitation,
treat
mother
fetus
aggressively,
consult
psychiatric
services
early.
World Journal of Emergency Medicine,
Journal Year:
2023,
Volume and Issue:
15(2), P. 83 - 83
Published: Dec. 7, 2023
Agitation
is
a
common
presentation
within
emergent
departments
(EDs).
during
pregnancy
should
be
treated
as
an
obstetric
emergency,
the
distress
may
jeopardize
both
patient
and
fetus.
The
safety
of
psychotropic
medications
in
reproductive
age
female
has
not
been
well
established.
This
review
aimed
to
explore
summary
general
agitation
recommendations
with
emphasis
on
ED
management
pregnancy.
Revista de Obstetricia y Ginecología de Venezuela,
Journal Year:
2024,
Volume and Issue:
84(01), P. 91 - 95
Published: Feb. 22, 2024
Denial
of
pregnancy
is
a
rare,
potentially
dangerous
disorder
that
can
be
divided
into
two
variants:
psychotic
and
nonpsychotic.
Psychotic
denial
typically
accompanied
by
history
mental
illness.
Negative
effects
include
psychological
distress,
unsupported
births
outside
hospital,
potential
rise
in
mother
newborn
morbi-mortality.
It
crucial
to
personal
and/or
family
psychopathology
as
part
the
anamnesis
because
this
condition
should
treated
psychiatrist.
Regarding
management
during
or
puerperium,
there
are
no
specific
recommendations.
To
provide
comprehensive
care,
multidisciplinary
approach
required.
A
case
presented.
Keywords:
pregnancy,
Pregnancy
denial,
Mental
illness,
Psychiatry,
health.
Current Neuropharmacology,
Journal Year:
2024,
Volume and Issue:
22(14), P. 2402 - 2421
Published: May 17, 2024
There
is
much
debate
about
continuing
antipsychotic
medication
in
patients
who
need
it
when
they
become
pregnant
because
benefits
must
be
weighed
against
potential
teratogenic
and
malformation
effects
related
to
antipsychotics
themselves.
To
address
this,
we
conducted
a
systematic
review
on
the
PubMed,
PsycINFO
CINHAL
databases
ClinicalTrials.gov
register
using
following
strategy:
(toxicity
OR
teratogenicity
malformation*
"birth
defect*"
"congenital
abnormality"
abnormalities"
"brain
changes"
"behavioral
abnormalities")
AND
antipsychotic*
(pregnancy
lactation
delivery
prenatal
perinatal
post-natal
puerperium)
September
27,
2023.
We
found
38
studies
eligible.
The
oldest
was
published
1976,
while
most
articles
were
recent.
Most
concluded
that
antipsychotics,
especially
second-generation
devoid
of
potential,
few
inconclusive
recommended
replication.
authoritative
from
Boston
area,
where
large
implemented
study
psychiatric
drugs.
Other
reliable
are
Northern
European
registers.
Overall
conclusions
no
more
malformations
than
disorders
themselves;
recommend
there
reasons
discontinue
medications
pregnancy.
Current Problems of Psychiatry,
Journal Year:
2024,
Volume and Issue:
25, P. 156 - 164
Published: Aug. 2, 2024
Introduction:
Schizophrenia
affects
as
many
24
million
people
worldwide.
Similar
to
the
general
population
of
women,
it
is
estimated
that
every
second
woman
with
schizophrenia
becomes
a
mother.
The
purpose
article
present
difficulties
pregnancy
brings
for
women
in
terms
physical
and
mental
health
course
disease.
Material
methods:
available
literature
English
Polish
languages
was
reviewed
by
searching
PubMed
Google
Scholar
databases.
Articles
published
from
2009
2023
were
selected
using
following
words:
schizophrenia,
pregnancy,
hormones,
treatment
outcomes.
analysis
encompassed
original
studies,
meta-analyses,
randomized
controlled
trials,
review
articles.
Results:
One
most
significant
problems
related
motherhood
among
patients
lack
access
knowledge
about
family
planning,
sexuality
parenting.
Women
are
more
likely
engage
risky
sexual
contact,
usually
their
pregnancies
unplanned.
influence
on
still
not
clear.
Studies
show
changes
hormone
levels
during
especially
estrogen
levels,
play
protective
role
occurrence
schizophrenic
episodes.
Nonetheless,
pregnant
have
higher
risk
miscarriage,
infant
deaths,
obesity,
gestational
diabetes,
hypertension
other
obstetric
complications.
Conclusions:
Due
fact
nowadays
may
become
mothers,
crucial
provide
adequate
reproductive
life
ensure
them
professional,
interdisciplinary
medical
psychological
care
pregnancy.
Keywords:
treatment,
outcomes
medRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 23, 2024
Abstract
This
study
employed
physiologically
based
pharmacokinetic
(PBPK)
modelling
to
compare
the
extent
of
fetal
exposure
between
oral
and
long-acting
injectable
(LAI)
aripiprazole
olanzapine.
Adult
pregnancy
PBPK
models
were
developed
validated
with
relevant
clinical
data.
Relevant
indices
during
predicted
from
concentration-time
data
at
steady-state
dosing
for
both
LAI
formulations.
Fetal
C
max
was
59-78%
higher
than
oral,
68-181%
olanzapine
formulation.
Predicted
C:M
ratios
(range)
0.59-0.69
0.61-0.66
aripiprazole,
0.34-0.64
0.89-0.96
Also,
cumulative
over
28
days
formulations
generally
be
lower
compared
their
therapeutic-equivalent
LAI.
As
in
utero
maternal
drugs
does
not
necessarily
translate
risk,
these
should
interpreted
a
broader
context
that
includes
benefit-risk
assessments.
Revista Contemporânea,
Journal Year:
2024,
Volume and Issue:
4(11), P. e6699 - e6699
Published: Nov. 25, 2024
Introdução:
Em
virtude
das
graves
repercussões
da
insônia
sobre
a
saúde
do
binômio
materno-fetal,
esforços
vêm
sendo
despendidos
no
sentido
de
encontrar
alternativas
terapêuticas
eficientes
e
seguras.
Objetivos:
vista
disso,
objetivou-se
reunir
as
evidências
disponíveis
acerca
dos
fármacos
comumente
prescritos
às
gestantes
para
o
tratamento
em
relação
aos
efeitos
potencialmente
deletérios
tendo
que
impacto
negativo
distúrbio
não
tratado
deve
ser
levado
consideração.
Metodologia:
Trata-se
uma
revisão
sistemática
literatura
realizada
por
meio
buscas
artigos
indexados
nas
bases
dados
MEDLINE,
LILACS
IBECS.
Resultados:
Ao
total
foram
selecionados
19
estudos
cujos
resultados
evidenciaram
opções
farmacológicas
na
gestação
incluem
benzodiazepínicos
medicamentos
relacionados
benzodiazepínicos,
como
Z,
antipsicóticos,
antidepressivos
sedativos
melatonina.
A
os
evidencia
melhora
sono,
mas
existem
adequados
bem
controlados
humanos
segurança
clínica,
riscos
à
materno-fetal.
Sugere-se
benefícios
potenciais
podem
justificar
uso
medicamento
mulheres
grávidas,
sobretudo
nos
casos
quando
há
terapêuticas.
Conclusão:
Por
se
tratar
um
grande
desafio
prática
diretrizes
internacionais
estabelecem
abordagem
compartilhada
tomada
decisão,
envolvendo
gestante
seus
familiares,
prescrição
terapia
farmacológica
durante
gravidez.
