Comparative study for fatigue prevalence in subjects with diseases: a systematic review and meta-analysis

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Oct. 7, 2024

Fatigue is one of the common symptoms in individuals with diseases or disorders, significantly affecting quality life (QoL) and prognosis diseases. This study aimed to comprehensively compare features fatigue across a wide range We systematically searched PubMed Cochrane Library databases from inception March 31st, 2021, conducted meta-analysis generate precise estimates. The analyses were stratified by classification diseases, gender, severity (moderate severe), was assessed using Newcastle-Ottawa Scale (NOS). In total, 214 articles (233 prevalence data) met our eligibility criteria, covering 102,024 participants (mean 438 ± 1,421) 88 Among these, seventy-eight data sets (52,082 participants) thirty-nine (10,389 reported gender- severity-related prevalence. overall among subjects 49.4% [95% CI 46.9-52.1]. According International Classification Diseases-10 (ICD-10) classification, highest (65.9% 54.9-79.6]) observed patients mental/behavioral whereas lowest (34.7% 24.5-49.2]) found those circulatory system A slight female dominance (43.5% vs. 49.8%) total data, most notable predominance (1.8-fold) seen low back pain. top disease groups moderate severe level included gastroparesis (92.3%), pulmonary hypertension (90.0%), chronic obstructive (COPD, 83.2%), multiple sclerosis (80.0%). These results are first show comparative Our findings provide valuable reference for future research on management fatigue.Prospero registration number: CRD42021270494.

Language: Английский

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The association among individual gray matter volume of frontal-limbic circuitry, fatigue susceptibility, and comorbid neuropsychiatric symptoms following COVID-19

NeuroImage, Journal Year: 2025, Volume and Issue: 306, P. 121011 - 121011

Published: Jan. 9, 2025

Language: Английский

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FMRI Insights into the Neural Alterations and Clinical Correlates in Multiple Sclerosis: A Comprehensive Overview of Systematic Reviews and Meta-Analyses

Brain Research Bulletin, Journal Year: 2025, Volume and Issue: 223, P. 111278 - 111278

Published: Feb. 26, 2025

Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by inflammatory demyelination in the central nervous system. Functional Magnetic Resonance Imaging (fMRI) has emerged as an effective method for studying MS pathology. This review provides comprehensive overview of fMRI applications, clarifying alterations brain activity and identifying relevant biomarkers. A systematic search electronic databases manual reference list checks at March 2024 yielded 470 articles. After duplicate removal, 456 articles underwent screening, 44 were assessed full, 12 reviews meta-analyses met inclusion criteria. Quality assessment was conducted. Included studies reported high methodological quality. revealed decreased functional connectivity within default mode network, correlating with impaired information processing speed, increased compensatory networks during working memory tasks. Graph theory metrics identified disrupted global efficiency clustering networks, linked to gray matter atrophy. Neuroplasticity demonstrated cortical reorganization after cognitive rehabilitation, particularly prefrontal cortex. MS-related fatigue associated altered anterior cingulate cortex thalamic activity, while depression correlated reduced amygdala-prefrontal connectivity. enhanced understanding MS, revealing specific neural correlates decline, neuroplasticity, fatigue, depression. However, variability subtypes non-standardized protocols hinder consistency, motion artifacts cerebral blood flow changes complicate interpretation. Standardizing imaging integrating novel techniques could improve reliability enable clinical applications optimize patient monitoring interventions.

Language: Английский

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Replicating human characteristics: A promising animal model of central fatigue

Brain Research Bulletin, Journal Year: 2024, Volume and Issue: 212, P. 110951 - 110951

Published: April 19, 2024

Central fatigue is a common pathological state characterized by psychological loss of drive, lack appetite, drowsiness, and decreased psychic alertness. The mechanism underlying central still unclear, there no widely accepted successful animal model that fully represents human characteristics. We aimed to construct more clinically relevant comprehensive fatigue. In this study, we utilized the Modified Multiple Platform Method (MMPM) combined with alternate-day fasting (ADF) create model. group rats are placed on stationary water environment platform for sleep deprivation at fixed time each day, they were subjected ADF treatment. On non-fasting days, allowed unrestricted access food. This process was sustained over period 21 days. evaluated using behavioral assessments such as open field test, elevated plus maze tail suspension Morris grip strength forced swimming well serum biochemical laboratory indices. Additionally, conducted observations hippocampus quadriceps muscle tissues, transmission electron microscope observation mitochondrial ultrastructure, assessment energy metabolism oxidative stress-related markers. results revealed displayed emotional anomalies resembling symptoms depression anxiety, exploratory behavior, decline in learning memory function, signs skeletal fatigue, successfully replicating features negative emotions, cognitive decline, physical Pathological damage ultrastructural alterations observed accompanied abnormal stress form ATP increased ROS levels. conclusion, our ADF+MMPM comprehensively replicated promising preclinical research. Furthermore, pivotal role occurrence tissues corroborated.

Language: Английский

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Fatigue and perceived energy in a sample of older adults over 10 years: A resting state functional connectivity study of neural correlates

Experimental Gerontology, Journal Year: 2024, Volume and Issue: 188, P. 112388 - 112388

Published: March 2, 2024

Declining energy and increasing fatigue, common in older age, predict neurodegenerative conditions, but their neural substrates are not known. We examined brain resting state connectivity relation to declining self-reported levels (SEL) occurrence of fatigue over time.

Language: Английский

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The effect of fatigue on postural control in individuals with multiple sclerosis: a systematic review

BMC Neurology, Journal Year: 2023, Volume and Issue: 23(1)

Published: Nov. 17, 2023

Abstract Background Fatigue is the most disabling symptom for individuals with multiple sclerosis (MS), which can significantly affect postural control (PC) by impairing ability of central nervous system to modulate sensory inputs and coordinate motor responses. This systematic review aimed investigate effect fatigue on PC in MS.. Methods reported according Preferred Reporting Items Systematic Reviews Meta-Analyses (PRISMA) guideline registered PROSPERO ID CRD42022376262. A search was performed Web Science, PubMed, Scopus, Google Scholar until January 2023, a manual using reference lists included studies. Two authors independently selected studies, extracted data, evaluated their methodological quality Downs Black checklist. The process later discussed third author.. Results Five studies were this review, consistent evidence investigating direct relationship between MS. All negative effects PC. Four employed walking tests as primary protocol inducing fatigue, while one study implemented strength testing both legs, serving fatigue-inducing activity. Conclusions suggests that MS may experience deficits due fatigue. However, present body literature exhibits limitations regarding its methodology. Gender differences, balance, task, muscle function are essential factors need be considered when Further high-quality research necessary comprehend complex interplay MS-related after physical

Language: Английский

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Evaluating the effects of brain injury, disease and tasks on cognitive fatigue

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: Nov. 17, 2023

Abstract Because cognitive fatigue (CF) is common and debilitating following brain injury or disease we investigated the relationships among CF, behavioral performance, cerebral activation within across populations by combining data from two cross-sectional studies. Individuals with multiple sclerosis (MS) were included to model CF resulting neurological disease; individuals who had sustained a traumatic (TBI) insult; both groups compared control group (Controls). was induced while neuroimaging acquired using different tasks. significantly differed between groups, clinical reporting more than Controls—a difference that statistically significant for TBI trended towards significance MS group. The accrual of did not differ three groups; ratings consistent Increasing associated longer response time all groups. in caudate nucleus thalamus consistently correlated dorsally caudate, These results suggest be central dorsal aspects may sensitive damage particular types insult.

Language: Английский

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Diffusion tensor imaging changes of the cortico-thalamic-striatal tracts correlate with fatigue and disability in people with relapsing-remitting MS

European Journal of Radiology, Journal Year: 2023, Volume and Issue: 170, P. 111207 - 111207

Published: Nov. 18, 2023

PurposeTo investigate how the microstructural neural integrity of cortico-thalamic-striatal (CTS) tracts correlate with fatigue and disability over time. The primary outcome was diffusion tensor imaging (DTI) metrics change time, secondary correlations in people RRMS (pw-RRMS).Methods76 clinically stable pw-RRMS 43 matched healthy controls (HCs). cohort consisted three different treatment subgroups. All participants underwent disability, cognitive, mental health assessments. Structural scans were performed at baseline (BL) 2-year follow-up (2-YFU) for all participants. Fractional anisotropy (FA), mean, radial axial diffusivities (MD, RD, AD) normal-appearing white matter (NAWM) lesion (WML) nine tracts-of-interests (TOIs) estimated using our MRtrix3 in-house pipeline.ResultsWe found significant BL 2-YFU differences most TOIs compared to HCs (pFDR≤0.001; false-detection-rate (FDR)-corrected). There a decrease WML an increase FA period (pFDR≤0.001). Additionally, there no DTI parameters across groups. AD MD positively correlated scores (r≤0.33, p≤0.01) NAWM-TOIs, while (EDSS) negatively NAWM-TOIs (|r|≤0.31, both time points. Disability diffusivity (r≤0.29, WML-TOIs points.ConclusionStatistically changes might be indicative improvement two years CTS pw-RRMS. This finding represents structural within lesioned tracts. Measuring affected relevant measure future remyelination clinical trials.

Language: Английский

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Fatigue may improve equally after balance and endurance training in multiple sclerosis: a randomised, crossover clinical trial

Frontiers in Neurology, Journal Year: 2024, Volume and Issue: 15

Published: Jan. 19, 2024

Introduction Fatigue and poor balance are frequent severe problems in multiple sclerosis (MS) that may interact. Endurance training is known to be effective on fatigue. This study aims test if more against MS Methods A randomised crossover trial was run, recruiting 31 people (21 women; median age: 46 years, range: 30–64; EDSS: 4, 2.5–5). Participants received endurance alternately (15 one-to-one sessions, 5 days/week) were assessed before (T0), after (T1), 30 days treatment ended (T2). The Modified Impact Scale (MFIS) with scores linearised through Rasch analysis the primary outcome (the lower measure, better condition, i.e., fatigue symptoms). Equiscale scale posturography (EquiTest) used assess balance. Linear mixed-effects models ANOVA for significance testing. Results Thirteen participants had no carryover effect included analysis. significantly changed across three time points ( F 2,58 = 16.0; p < 0.001), but difference treatments found. Altogether, both improved MFIS measure at T1 (95%CI: −1.24 logits; mean: −1.67 −0.81 logits) T2 −1.04; −1.49 −0.60) compared T0 −0.51; −0.95 −0.08; ≤ 0.001). highlighted improvement not training. Conclusion Balance could similarly reduce patients short term. However, only also MS.

Language: Английский

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Improvement of the thalamocortical white matter network in people with stable treated relapsing–remitting multiple sclerosis over time

NMR in Biomedicine, Journal Year: 2024, Volume and Issue: 37(6)

Published: Feb. 21, 2024

Abstract Advanced imaging techniques (tractography) enable the mapping of white matter (WM) pathways and understanding brain connectivity patterns. We combined tractography with a network‐based approach to examine WM microstructure on network level in people relapsing–remitting multiple sclerosis (pw‐RRMS) healthy controls (HCs) over 2 years. Seventy‐six pw‐RRMS matched 43 HCs underwent clinical assessments 3T MRI scans at baseline (BL) 2‐year follow‐up (2‐YFU). Probabilistic was performed, accounting for effect lesions, producing connectomes 25 million streamlines. Network differences fibre density across BL 2‐YFU were quantified using statistics (NBS). Longitudinal NBS pw‐RRMS, tested correlations disability, cognition fatigue scores. Widespread reductions found compared cortical regions, more detected 2‐YFU. Pw‐RRMS had reduced thalamocortical This appeared after correction age, robust different thresholds, did not correlate lesion volume or disease duration. demonstrated long‐distance improvement network, regardless burden, duration therapy, suggesting potential locus neuroplasticity MS. network's role disease's lifespan its implications prognosis treatment warrants further investigation.

Language: Английский

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