Unraveling Links between Chronic Inflammation and Long COVID: Workshop Report

The Journal of Immunology, Journal Year: 2024, Volume and Issue: 212(4), P. 505 - 512

Published: Feb. 5, 2024

As COVID-19 continues, an increasing number of patients develop long COVID symptoms varying in severity that last for weeks, months, or longer. Symptoms commonly include lingering loss smell and taste, hearing loss, extreme fatigue, "brain fog." Still, persistent cardiovascular respiratory problems, muscle weakness, neurologic issues have also been documented. A major problem is the lack clear guidelines diagnosing COVID. Although some studies suggest due to prolonged inflammation after SARS-CoV-2 infection, underlying mechanisms remain unclear. The broad range COVID-19's bodily effects responses initial viral infection are poorly understood. This workshop brought together multidisciplinary experts showcase discuss latest research on chronic might be associated with sequelae following infection.

Language: Английский

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Stress and Inflammation Target Dorsolateral Prefrontal Cortex Function: Neural Mechanisms Underlying Weakened Cognitive Control

Biological Psychiatry, Journal Year: 2024, Volume and Issue: unknown

Published: June 1, 2024

Language: Английский

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Cognitive Sequelae of COVID‐19: Mechanistic Insights and Therapeutic Approaches

CNS Neuroscience & Therapeutics, Journal Year: 2025, Volume and Issue: 31(3)

Published: March 1, 2025

ABSTRACT Background The COVID‐19 pandemic has left an indelible mark on the world, with mounting evidence suggesting that it not only posed acute challenges to global healthcare systems but also unveiled a complex array of long‐term consequences, particularly cognitive impairment (CI). As persistence post‐COVID‐19 neurological syndrome could evolve into next public health crisis, is imperative gain better understanding intricate pathophysiology CI in patients and viable treatment strategies. Methods This comprehensive review explores management across phases COVID‐19, from infection Long‐COVID, by synthesizing findings clinical, preclinical, mechanistic studies identify key contributors CI, as well current therapeutic approaches. Results Key mechanisms contributing include persistent neuroinflammation, cerebrovascular complications, direct neuronal injury, activation kynurenine pathway, psychological distress. Both pharmacological interventions, such anti‐inflammatory therapies agents targeting neuroinflammatory pathways, non‐pharmacological strategies, including rehabilitation, show promise addressing these challenges. Although much derived preclinical animal studies, provide foundational insights potential Conclusion By knowledge, this highlights importance COVID‐19‐related offers actionable for mitigation recovery community continues grapple pandemic's impact.

Language: Английский

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Greater executive dysfunction in patients post-COVID-19 compared to those not infected

Brain Behavior and Immunity, Journal Year: 2023, Volume and Issue: 114, P. 111 - 117

Published: Aug. 14, 2023

Language: Английский

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Longitudinal Exploration of Cortical Brain Activity in Cognitive Fog: An EEG Study in Patients with and without Anosmia

Journal of Integrative Neuroscience, Journal Year: 2024, Volume and Issue: 23(5)

Published: May 20, 2024

Background: Long-Covid, characterized by persistent symptoms following acute Covid-19 infection, represents a complex challenge for the scientific community. Among most common and debilitating manifestations, cognitive fog is neurological disorder mental confusion difficulties. In this study, we investigated long-term effects of previous infection on cortical brain activity in patients experiencing medium long term. Methods: A total 40 subjects (20 females 20 males) aged between 45 70 years (mean age (M) = 59.78, standard deviation (SD) 12.93) participated study. This sample included individuals with fog, both without anosmia, control group comprised healthy subjects. All electroencephalography (EEG) data were collected two sessions, 1 month 8 months after recovery from Covid-19, to measure neurophysiological parameters P300 beta band rhythms. Results: The results revealed significant differences rhythms affected these alterations persist even Covid-19. Interestingly, no observed participants anosmia associated fog. Conclusions: These findings provide contribution understanding have important implications future interventions aimed at managing treating symptoms. longitudinal assessment helps highlight impact virus health Long-Covid patients.

Language: Английский

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CURRENT CONCEPTS IN LONG-COVID BRAIN FOG AND POSTURAL ORTHOSTATIC TACHYCARDIA SYNDROME

Annals of Allergy Asthma & Immunology, Journal Year: 2024, Volume and Issue: 133(5), P. 522 - 530

Published: Aug. 23, 2024

Language: Английский

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Combined Use of Guanfacine and N-Acetylcysteine for the Treatment of Cognitive Deficits After Traumatic Brain Injury

Neurotrauma Reports, Journal Year: 2024, Volume and Issue: 5(1), P. 226 - 231

Published: March 1, 2024

Traumatic Brain Injury (TBI) is a significant contributor to disability across the world. TBIs vary in severity, and most cases are designated mild TBI (mTBI), involving only brief loss of consciousness no intracranial findings on imaging. Despite this categorization, many persons continue report persistent cognitive changes months years after injury, with particular impairment executive functions pre-frontal cortex. For these persons, there currently approved medications, treatment limited symptom management or behavioral therapy. The current case studies explored use alpha-2A adrenoreceptor agonist, guanfacine, combined antioxidant,

Language: Английский

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Cardiopulmonary rehabilitation’s influence on cognitive functions, psychological state, and sleep quality in long COVID-19 patients: A randomized controlled trial

Neuropsychological Rehabilitation, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 17

Published: April 12, 2024

Background: Cognitive impairment, brain fog, depressive symptoms, and sleep disturbance are prevalent symptoms among individuals with long COVID, for which there currently is no treatment. Aim: To assess the effectiveness of an eight-week cardiopulmonary rehabilitation programme on cognition, psychological well-being, quality in COVID-19. Methods: Forty participants diagnosed COVID-19 (26 female, 14 male participants; mean age 53 ± 11 years) were randomly assigned to a group or control group. The maintained their regular daily habits, while was prescribed individualized clinical consisting three sessions per week. Each session involved light moderate aerobic exercise, resistance training, respiratory exercises. Neuropsychological tests evaluating executive function, memory, processing speed administered at baseline study completion. Participants also completed questionnaires state both time points. Results: No difference between groups observed neuropsychological test performance, however significant differences perceived stress depression found post-intervention. Conclusion: Cardiopulmonary shown be effective suffering from COVID terms decreasing levels but not performance.

Language: Английский

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The association between memory, COVID-19 testing, and COVID-19 incidence in middle-aged and older adults: a prospective analysis of the CLSA

Aging Neuropsychology and Cognition, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 18

Published: April 16, 2024

We investigated the association between pre-COVID-19 memory function and (a) receipt of a COVID-19 test (b) incidence using Questionnaire Study (CQS) Canadian Longitudinal on Aging (CLSA). The CQS included 28,565 middle-aged older adults. regressed participants' immediate delayed recall scores re-ran regression models with as outcome. All were adjusted for sociodemographic, lifestyle, health covariates. In analytical sample (n = 21,930), higher (better memory) was significantly associated lower incidence. However, this not significant memory. Immediate test. Health policymakers practitioners may viewmemory status potential risk COVID-19. Memory be barrier to testing.

Language: Английский

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How Mild Is the Mild Long COVID? A Comprehensive Neuropsychological Assessment of Patients with Cognitive Complaints

Archives of Clinical Neuropsychology, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 23, 2024

The global impact of the Coronavirus Disease (COVID-19) pandemic has extended beyond physical health, leading to widespread mental health issues. Beyond respiratory symptoms, there is a growing concern about long-term cognitive effects, particularly in individuals who experienced mild cases infection. We aimed investigate neuropsychological aspects COVID-19 non-hospitalized adults compared with control group. This cross-sectional study included 42 participants, 22 history COVID, and 20 healthy controls. participants were recruited from community underwent comprehensive assessment. Participants COVID group reported symptoms persisting for an average 203.86 days presented higher frequency psychological treatment (81.8%) (25.0%). History anxiety disorders was more prevalent (63.6%) than (20.0%). Significant reductions verbal working memory observed Levels found have significant on difficulties visual recognition memory. reveals important alterations following COVID-19, emphasizing executive functions deficits. Our findings underscore persistence these deficits even cases, suggesting potential inflammatory mechanisms central nervous system. highlights need assessments targeted interventions address diverse impacts recovering COVID-19.

Language: Английский

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