A systematic review and meta-analysis of the impact of transcranial direct current stimulation on cognitive function in older adults with cognitive impairments: the influence of dosage parameters

Alzheimer s Research & Therapy, Journal Year: 2025, Volume and Issue: 17(1)

Published: Feb. 4, 2025

Numerous studies have demonstrated the effects of transcranial direct current stimulation (tDCS) on cognitive function in older people. This study further explores impact tDCS and its dosage parameters enhancement people with impairments. Randomized controlled trials (RCTs) published through November 2023 were retrieved from databases including PubMed, Scopus, EMBASE, EBSCO, Cochrane Library. Participants adults impairments, Alzheimer's disease (AD), mild impairment (MCI), dementia. AD was diagnosed based Diagnostic Statistical Manual Mental Disorders, Fourth Edition (DSM-IV), or National Institute Neurological Communicative Disorders Stroke – Alzheimer' Disease Related Association (NINCDS-ADRDA) criteria. Dementia using DSM-V NINCDS-ADRDA criteria, while MCI DSM-V, Petersen assessments such as Montreal Cognitive Assessment (MoCA) Clinical Rating (CDR). Standardized mean difference (SMD) values analyzed to assess effects. A total 19 RCTs included. significantly improved Mini-Mental State Examination score both immediately post-intervention (SMD = 0.51, p 0.005) at follow-up 2.29, 0.0003). Significant observed when used alone 0.39, 0.04), densities $$\le$$ 0.06 mA/cm2 0.25, session durations exceeding 20 min 0.89, 0.01), up 15 sessions 0.28, 0.009), an active electrode placed over temporal area 0.33, 0.02). People showed greater improvements compared those dementia 0.91, However, did not improve memory executive function. efficacy enhancing global cognition providing insight into optimal for clinical application. no improvement

Language: Английский

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Transcranial Direct Current Stimulation for Global Cognition in Mild Cognitive Impairment

Chonnam Medical Journal, Journal Year: 2025, Volume and Issue: 61(1), P. 1 - 1

Published: Jan. 1, 2025

Mild cognitive impairment (MCI) is a condition characterized by noticeable deficits in memory retrieval or other domains than the individuals with same age but do not significantly interfere daily functioning. It represents an intermediate stage between normal aging and dementia, crucial opportunity for intervention prior to extensive decline. Transcranial direct current stimulation (tDCS), non-invasive neuromodulation technique, has shown promise enhancing global cognition MCI. Current evidence suggests that tDCS provides short-term benefits, particularly attention, moderate effects observed processing speed. However, its impact on executive function language remains inconsistent, highlighting variability individual responses study methodologies. While long-term efficacy uncertain due limited longitudinal research short follow-up periods, safety concerns, especially self-administered such as home-based tDCS, underscore need proper training device innovation. Despite this, promising, portable tool enhancement MCI, potential delay progression dementia. Addressing challenges optimizing protocols, accounting neuroanatomical variability, establishing effectiveness will be essential broader clinical adoption. Future should focus standardizing methodologies, incorporating biomarkers predict treatment response, conducting large-scale, studies refine therapeutic application.

Language: Английский

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Long-lasting improvements in episodic memory among subjects with mild cognitive impairment who received transcranial direct current stimulation combined with cognitive treatment and telerehabilitation: a multicentre, randomized, active-controlled study

Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16

Published: June 18, 2024

Background In recent years, an increasing number of studies have examined the potential efficacy cognitive training procedures in individuals with normal ageing and mild impairment (MCI). Objective The aims this study were to (i) evaluate Virtual Reality Rehabilitation System (VRRS) combined anodal transcranial direct current stimulation (tDCS) applied left dorsolateral prefrontal cortex compared placebo tDCS VRRS (ii) determine how prolong beneficial effects treatment. A total 109 subjects MCI assigned 1 5 groups a randomized controlled trial design: (a) face-to-face (FTF) during followed by telerehabilitation (TR) (clinic-atDCS-VRRS+Tele@H-VRRS); (b) FTF TR (clinic-ptDCS-VRRS+Tele@H-VRRS); (c) (clinic-VRRS+Tele@H-VRRS); (d) at-home unstructured (clinic-VRRS+@H-UCS); (e) treatment as usual (clinic-TAU). Results An improvement episodic memory was observed after end clinic-atDCS-VRRS ( p < 0.001). We found no enhancement clinic-ptDCS-VRRS or clinic-TAU. Moreover, led prolonged (clinic-atDCS-VRRS+Tele@H-VRRS vs. clinic-ptDCS-VRRS+Tele@H-VRRS: = 0.047; clinic-atDCS-VRRS+Tele@H-VRRS clinic-VRRS+Tele@H-VRRS: 0.06). Discussion present provides preliminary evidence supporting use individualized for rehabilitation. Clinical registration https://clinicaltrials.gov/study/NCT03486704?term=NCT03486704&rank=1 , NCT03486704.

Language: Английский

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Non-invasive, non-convulsive brain stimulation beyond TMS and ECT in late-life mental disorders: a systematic review

Journal of Affective Disorders Reports, Journal Year: 2024, Volume and Issue: unknown, P. 100844 - 100844

Published: Sept. 1, 2024

Language: Английский

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Combined Effect of tDCS and Motor or Cognitive Activity in Patients with Alzheimer’s Disease: A Proof-of-Concept Pilot Study

Brain Sciences, Journal Year: 2024, Volume and Issue: 14(11), P. 1099 - 1099

Published: Oct. 30, 2024

(1) Background: Alzheimer's disease (AD) accounts for 70% of dementia cases and with no effective pharmacological treatments, new rehabilitation methods are needed. Motor cognitive activities transcranial direct current stimulation (tDCS) have shown promise in stabilizing enhancing functions. Objective: we want to investigate the effects tDCS combined motor or activity on functions AD patients. (2) Methods: Patients mild moderate were randomized between anodic groups (MotA CogA) sham (MotS CogS). They received two weeks treatment (45 min, five days/week), first 15 min using dorsolateral prefrontal cortex. Cognitive assessments conducted pre-treatment (T0), post-treatment (T1), one week after (T2). (3) Results: Twenty-three patients included. Statistical analysis showed significant differences + CogS) advantages improving global status (

Language: Английский

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