Pituitary entry zone: Newly Midline Hypovascular Area in Pituitary Gland DOI
Gerardo Marín, Carlos Castillo-Rangel, Cristofer Zarate-Calderon

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: May 7, 2025

Abstract Background Clinical observations suggest relative preservation of endocrine function following midline incisions during transsphenoidal pituitary surgery despite the gland's rich vascularity. This study investigated intrapituitary microvascular architecture to identify a potential anatomical correlate for this functional resilience. Methods descriptive observational utilized three human cadaveric glands. Histological sections were prepared in sagittal and coronal planes. Immunohistochemistry endothelial marker CD34 was performed assess density (MVD). MVD quantified compared between central region peripheral zone both sections. Results In plane, significantly reduced (mean: 7,642 vessels/mm²) 31,330 vessels/mm²). Conversely, no significant difference observed 32,090 28,270 regions plane. Conclusion identifies distinct hypovascularity along gland, which we propose naming Pituitary entry (PEZ). finding offers histological basis after surgical approaches. While limited by small sample size, these results highlight previously under-characterized aspect angioarchitecture that may represent safer corridor intervention. Further investigation correlating with postoperative outcomes is warranted.

Language: Английский

Pituitary entry zone: Newly Midline Hypovascular Area in Pituitary Gland DOI
Gerardo Marín, Carlos Castillo-Rangel, Cristofer Zarate-Calderon

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: May 7, 2025

Abstract Background Clinical observations suggest relative preservation of endocrine function following midline incisions during transsphenoidal pituitary surgery despite the gland's rich vascularity. This study investigated intrapituitary microvascular architecture to identify a potential anatomical correlate for this functional resilience. Methods descriptive observational utilized three human cadaveric glands. Histological sections were prepared in sagittal and coronal planes. Immunohistochemistry endothelial marker CD34 was performed assess density (MVD). MVD quantified compared between central region peripheral zone both sections. Results In plane, significantly reduced (mean: 7,642 vessels/mm²) 31,330 vessels/mm²). Conversely, no significant difference observed 32,090 28,270 regions plane. Conclusion identifies distinct hypovascularity along gland, which we propose naming Pituitary entry (PEZ). finding offers histological basis after surgical approaches. While limited by small sample size, these results highlight previously under-characterized aspect angioarchitecture that may represent safer corridor intervention. Further investigation correlating with postoperative outcomes is warranted.

Language: Английский

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