Apigenin mitigates oxidative stress, neuroinflammation, and cognitive impairment but enhances learning and memory in aluminum chloride‐induced neurotoxicity in rats

Alzheimer s & Dementia, Journal Year: 2025, Volume and Issue: 21(5)

Published: May 1, 2025

Abstract INTRODUCTION Aluminum chloride (AlCl 3 ) exposure has been linked to neurotoxicity in various animal models, presenting significant concern human health due its potential implications neurodegenerative diseases. is a widely recognized neurotoxin and used as an model of Alzheimer's disease via mechanisms with oxidative stress inflammation. The study investigated the ameliorative effect apigenin on AlCl ‐induced rats. METHODS Forty adult male Wistar rats were randomly divided into four different groups – control, (100 mg/kg), (50 mg/kg) plus , alone administered orally for 14 days. RESULTS Our findings revealed induced neurobehavioral deficits, stress, neuroinflammation, loss Purkinje cell layer cerebellum. Treatment attenuated neuroinflammation enhanced learning memory improvement recognition index. DISCUSSION Apigenin demonstrates promising effects against Highlights toxicity caused reduction learning, exploration, memory. neurotoxicity, increased biomarkers precipitated cognitive impairment. improved brain antioxidant,

Language: Английский

Quantifying Variability in Zebrafish Larvae Locomotor Behavior across Experimental Conditions: A Learning-Based Tracker

Fishes, Journal Year: 2024, Volume and Issue: 9(6), P. 193 - 193

Published: May 23, 2024

This study investigated the effects of environmental changes on zebrafish larval behavior, using single-factor and orthogonal experiments to assess locomotion during temperature pH changes. In experiments, larvae were exposed variations in (22 30 °C) levels (6.0, 7.0, 9.0). The simultaneous by tests. both each larva was recorded three 5 min videos at different stages (before exposure, short-term exposure (10 min), after long-term (60 min)). You Look Only Once (YOLOv5) Deep Simple Online Real Time Tracking (DeepSORT) models adopted develop a tracking system, YOLOv5 improved two aspects anchor clustering network structure. accuracy system for small targets effectively improved, reaching more than 98% MOTA (Multiple Object Accuracy). Principal Component Analysis (PCA) employed extract behavioral features from 13 motion parameters, namely activity, edge direction preference. Our findings reveal that lower temperatures acidic conditions led decrease former also increased behavior. Conversely, elevated alkaline had muted impact these behaviors. Interestingly, concurrent significantly altered directional Additionally, we observed elicited distinct temporal patterns constant level. summary, recommend precise control explicit reporting ambient breeding devices experimental wells minimize behavior enhance experiment repeatability reliability.

Language: Английский

Effects of Valproic Acid Embryonic Exposure on Zebrafish: A Systematic Review and Meta-Analysis

NeuroSci, Journal Year: 2024, Volume and Issue: 5(4), P. 650 - 665

Published: Dec. 7, 2024

Exposure to valproic acid (VPA) during embryogenesis has become a valuable tool for modeling neurodevelopmental disorders in animal models such as zebrafish (

Language: Английский