Tactics with Prebiotics for the Treatment of Metabolic Dysfunction-Associated Fatty Liver Disease via the Improvement of Mitophagy DOI Open Access
Ai Tsuji, Sayuri Yoshikawa, Yuka Ikeda

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(6), P. 5465 - 5465

Published: March 13, 2023

Mitophagy/autophagy plays a protective role in various forms of liver damage, by renovating cellular metabolism linking to sustain homeostasis. A characterized pathway for mitophagy is the phosphatase and tensin homolog (PTEN)-induced putative kinase 1 (PINK1)/Parkin-dependent signaling pathway. In particular, PINK1-mediated could play an indispensable improving metabolic dysfunction-associated fatty disease (MAFLD) which precede steatohepatitis (NASH), fibrosis, hepatocellular carcinoma. addition, PI3K/AKT/mTOR might regulate characteristics homeostasis including energy metabolism, cell proliferation, and/or protection. Therefore, targeting with alteration or PINK1/Parkin-dependent eliminate impaired mitochondria be attractive strategy treatment MAFLD. efficacy prebiotics MAFLD has been suggested useful via modulation PI3K/AKT/mTOR/AMPK Additionally, several edible phytochemicals activate improvement mitochondrial damages, also promising option treat providing Here, potential therapeutics discussed Tactics viewpoint prospective probiotics contribute development therapeutic interventions.

Language: Английский

Global Impacts of Western Diet and Its Effects on Metabolism and Health: A Narrative Review DOI Open Access
Vicente Javier Clemente‐Suárez, Ana Isabel Beltrán-Velasco, Laura Redondo-Flórez

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(12), P. 2749 - 2749

Published: June 14, 2023

The Western diet is a modern dietary pattern characterized by high intakes of pre-packaged foods, refined grains, red meat, processed high-sugar drinks, candy, sweets, fried conventionally raised animal products, high-fat dairy and high-fructose products. present review aims to describe the effect on metabolism, inflammation, antioxidant status; impact gut microbiota mitochondrial fitness; cardiovascular health, mental cancer; sanitary cost diet. To achieve this goal, consensus critical was conducted using primary sources, such as scientific articles, secondary including bibliographic indexes, databases, web pages. Scopus, Embase, Science Direct, Sports Discuss, ResearchGate, Web were used complete assignment. MeSH-compliant keywords “Western diet”, “inflammation”, “metabolic health”, fitness”, “heart disease”, “cancer”, “oxidative stress”, “mental “metabolism” used. following exclusion criteria applied: (i) studies with inappropriate or irrelevant topics, not germane review’s focus; (ii) Ph.D. dissertations, proceedings conferences, unpublished studies. This information will allow for better comprehension nutritional behavior its an individual’s metabolism well national systems. Finally, practical applications derived from are made.

Language: Английский

Citations

339

The Gut Microbiota and Respiratory Diseases: New Evidence DOI Creative Commons
Chunxi Li, Haiyue Liu,

Lin Yanxia

et al.

Journal of Immunology Research, Journal Year: 2020, Volume and Issue: 2020, P. 1 - 12

Published: July 31, 2020

Human body surfaces, such as the skin, intestines, and respiratory urogenital tracts, are colonized by a large number of microorganisms, including bacteria, fungi, viruses, with gut being most densely extensively organ. The microbiome plays an essential role in immune system development tissue homeostasis. Gut microbiota dysbiosis not only modulates responses gastrointestinal (GI) tract but also impacts immunity distal organs, lung, further affecting lung health diseases. Here, we review recent evidence correlations underlying mechanisms relationship between common diseases, asthma, chronic obstructive pulmonary disease (COPD), cystic fibrosis (CF), cancer, infection, probiotic therapeutic intervention for these

Language: Английский

Citations

205

Nutritional Imbalances in Adult Celiac Patients Following a Gluten-Free Diet DOI Open Access

A. Gutiérrez Cardo,

Itziar Churruca, Arrate Lasa

et al.

Nutrients, Journal Year: 2021, Volume and Issue: 13(8), P. 2877 - 2877

Published: Aug. 21, 2021

Celiac disease (CD) is a chronic autoimmune disorder of the small intestine, whose only effective treatment gluten-free diet (GFD). It characterized by atrophy intestinal villi that leads to altered nutrient absorption. This study describes nutritional imbalances which may be found in adults with CD following GFD. During first year treatment, deficiencies will overcome as mucosa recovers. Thus, biochemical data show this progression, together decrease symptoms. In contrast, long term, when strict GFD followed and mucosal recovery achieved, analyzing intake makes more sense. Macronutrient consumption its low complex carbohydrate fiber intakes, high fat (especially SFA) sugar intakes. profile has been related GFP their composition, addition unbalanced dietary habits. The most notable micronutrients are usually those iron, calcium magnesium vitamin D, E some group B. necessary follow up patients promote education among them, since it could help not achieve gluten free but also balanced diet.

Language: Английский

Citations

174

Therapeutic Benefits and Dietary Restrictions of Fiber Intake: A State of the Art Review DOI Open Access
Corina-Bianca Ioniță-Mîndrican,

Khaled Ziani,

Magdalena Mititelu

et al.

Nutrients, Journal Year: 2022, Volume and Issue: 14(13), P. 2641 - 2641

Published: June 26, 2022

Throughout history, malnutrition and deficiency diseases have been a problem for our planet's population. A balanced diet significantly influences everyone's health, fiber intake appears to play more important role than previously thought. The natural dietary fibers are category of carbohydrates in the constitution plants that not completely digested human intestine. High-fiber foods, such as fruits, vegetables whole grains, consistently highly beneficial health effectively reduced risk disease. Although mode action consumer body is fully understood, nutritionists professionals unanimously recognize therapeutic benefits. This paper presents consumption different countries, metabolism range benefits associated with intake. In addition, influence on intestinal microbiome, metabolic (obesity diabetes), neurological aspects, cardiovascular diseases, autoimmune cancer prevention discussed. Finally, restrictions excess addressed, which can cause episodes diarrhea dehydration increase likelihood bloating flatulence or even bowel obstruction. However, extensive studies needed regarding composition required amount relation saprotrophic microorganisms from enteral level various pathologies they be correlated.

Language: Английский

Citations

160

Environmental Influences on the Human Microbiome and Implications for Noncommunicable Disease DOI
Jiyoung Ahn, Richard B. Hayes

Annual Review of Public Health, Journal Year: 2021, Volume and Issue: 42(1), P. 277 - 292

Published: April 1, 2021

The human microbiome contributes metabolic functions, protects against pathogens, educates the immune system, and through these basic directly or indirectly, affects most of our physiologic functions. Here, we consider its relationship to several major noncommunicable conditions, including orodigestive tract cancers, neurologic diseases, diabetes, obesity. We also highlight scope contextual macroenvironmental factors (toxicological chemical environment, built socioeconomic environment) individual microenvironmental (smoking, alcohol, diet) that may push microbiota toward less healthy more influencing development diseases. Last, current uncertainties challenges in study environmental influences on implications for understanding disease, suggesting a research agenda strengthen scientific evidence base.

Language: Английский

Citations

119

Overview of the distinctive characteristics of strawberry, raspberry, and blueberry in berries, berry wines, and berry spirits DOI Creative Commons
Mário Bezerra, Miguel Ribeiro, Fernanda Cosme

et al.

Comprehensive Reviews in Food Science and Food Safety, Journal Year: 2024, Volume and Issue: 23(3)

Published: April 29, 2024

Abstract Red berries have gained popularity as functional and nutritious food due to their health benefits, leading increased consumer demand higher production, totaling over 11,000 ktons for strawberries, raspberries, blueberries combined in 2021. Nutritionally, present high levels of vitamin C (9.7–58.8 mg/100 g dry weight [dw]), folates (6–24 µg/100 dw), minerals (96–228 dw). Due perishable nature, producers utilized alcoholic fermentation extend shelf life, not only increasing the lifespan red but also attracting consumers through production novel beverages. Strawberry, blueberry, raspberry wines possess low alcohol (5.5–11.1% v/v), acidity (3.2–17.6 g/L), interesting bioactive molecules such phenolic compounds, carotenoids, polysaccharides, melatonin. Distillation holds tremendous potential reducing waste by creating berry spirits exceptional quality. Although research on is still early stages, future studies should focus characterization. By incorporating these factors, chain would become more sustainable, profitable, efficient waste, capitalizing acceptance, leveraging natural health‐promoting characteristics products. Therefore, this review aims provide a comprehensive overview strawberry, berries, wines, spirits, with chemical composition methods.

Language: Английский

Citations

19

The small intestine shields the liver from fructose-induced steatosis DOI
Cholsoon Jang, Shogo Wada, Steven Yang

et al.

Nature Metabolism, Journal Year: 2020, Volume and Issue: 2(7), P. 586 - 593

Published: June 22, 2020

Language: Английский

Citations

116

Relation of Fruits and Vegetables with Major Cardiometabolic Risk Factors, Markers of Oxidation, and Inflammation DOI Open Access

María Lapuente,

Ramón Estruch,

Mana Shahbaz

et al.

Nutrients, Journal Year: 2019, Volume and Issue: 11(10), P. 2381 - 2381

Published: Oct. 6, 2019

Noncommunicable diseases (NCDs) are considered to be the leading cause of death worldwide. Inadequate fruit and vegetable intake have been recognized as a risk factor for almost all NCDs (type 2 diabetes mellitus, cancer, cardiovascular neurodegenerative diseases). The main aim this review is examine possible protective effect that consumption or their bioactive compounds may on development such atherosclerosis. accumulated evidence effects adequate fruits vegetables in some cases, lack others, summarized present review. conclusion well-designed, large-scale, long-term studies needed truly understand role

Language: Английский

Citations

91

Antioxidant pectin enriched fractions obtained from discarded carrots (Daucus carota L.) by ultrasound-enzyme assisted extraction DOI

Alondra M. Idrovo Encalada,

Carolina D. Pérez, Silvia K. Flores

et al.

Food Chemistry, Journal Year: 2019, Volume and Issue: 289, P. 453 - 460

Published: March 18, 2019

Language: Английский

Citations

82

Diarrhea Predominant-Irritable Bowel Syndrome (IBS-D): Effects of Different Nutritional Patterns on Intestinal Dysbiosis and Symptoms DOI Open Access
Annamaria Altomare, Claudia Di Rosa, Elena Imperia

et al.

Nutrients, Journal Year: 2021, Volume and Issue: 13(5), P. 1506 - 1506

Published: April 29, 2021

Irritable Bowel Syndrome (IBS) is a chronic functional gastrointestinal disorder characterized by abdominal pain associated with defecation or change in bowel habits. Gut microbiota, which acts as real organ well-defined functions, mutualistic relationship the host, harvesting additional energy and nutrients from diet protecting host pathogens; specific alterations its composition seem to play crucial role IBS pathophysiology. It well known that can significantly modulate intestinal microbiota profile but it less how different nutritional approach effective patients, such low-FODMAP diet, could be responsible of changes, thus influencing presence (GI) symptoms. The aim this review was explore effects protocols (e.g., traditional advice, gluten-free etc.) on IBS-D symptoms variations both patients healthy subjects. To date, an ideal protocol does not exist for seems consider effect approaches better define efficient strategy manage disorder.

Language: Английский

Citations

82