Polyphenols: Role in Modulating Immune Function and Obesity

Biomolecules, Journal Year: 2024, Volume and Issue: 14(2), P. 221 - 221

Published: Feb. 14, 2024

Polyphenols, long-used components of medicinal plants, have drawn great interest in recent years as potential therapeutic agents because their safety, efficacy, and wide range biological effects. Approximately 75% the world’s population still use plant-based compounds, indicating ongoing significance phytochemicals for human health. This study emphasizes growing body research investigating anti-adipogenic anti-obesity functions polyphenols. The polyphenols, including phenylpropanoids, flavonoids, terpenoids, alkaloids, glycosides, phenolic acids, are distinct due to changes chemical diversity structural characteristics. review methodically investigates mechanisms by which naturally occurring polyphenols mediate obesity metabolic function immunomodulation. To this end, hormonal control hunger has inhibit pro-obesity enzymes such pancreatic lipase, promotion energy expenditure, modulation adipocytokine production. Specifically, affect insulin, a hormone that is essential regulating blood sugar, they also play role, part, complex web factors progression obesity. explores immunomodulatory properties providing insight into ability improve immune effects on gut health, improving number commensal bacteria, cytokine production suppression, cell mediation, natural killer cells macrophages. Taken together, continuous studies required understand prudent precise underlying polyphenols’ In interim, holistic approach health promotes consumption foods drinks high lays groundwork future developments, derivatives may provide answer urgent worldwide issues. compilation knowledge paves way discoveries global treatment pressing concerns diseases.

Language: Английский

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Dietary Anthocyanins and Stroke: A Review of Pharmacokinetic and Pharmacodynamic Studies

Nutrients, Journal Year: 2019, Volume and Issue: 11(7), P. 1479 - 1479

Published: June 28, 2019

Cerebrovascular accidents are currently the second major cause of death and third leading disability in world, according to World Health Organization (WHO), which has provided protocols for stroke prevention. Although there is a multitude studies on health benefits associated with anthocyanin (ACN) consumption, no rigorous systematization data linking dietary ACN This review intended present from epidemiological, vitro, vivo, clinical dealing related ACN-rich diets or supplements, along possible mechanisms action revealed by pharmacokinetic studies, including passage through blood-brain barrier (BBB).

Language: Английский

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Effect of Quercetin-Loaded Mesoporous Silica Nanoparticles on Myocardial Ischemia-Reperfusion Injury in Rats and Its Mechanism

International Journal of Nanomedicine, Journal Year: 2021, Volume and Issue: Volume 16, P. 741 - 752

Published: Feb. 1, 2021

Background: Quercetin has potential value in treating cardiovascular diseases, but it is not suitable for clinical application due to its own water solubility.The limitation of quercetin can be distinctly ameliorated by delivering with nanocarriers.Objective: To determine the effect quercetin-loaded mesoporous silica nanoparticles (Q-MSNs) on myocardial ischemia-reperfusion injury rats and mechanism.Methods: Q-MSNs were synthesized, morphology MSNs was characterized transmission electron microscopy dynamic light scattering technique, respectively.Healthy enrolled randomly divided into a sham operation control group, an (IR) IR+Q IR+Q-MSNs group (each n = 10).Rats treated ischemia reperfusion, given normal perfusion meantime.Rats IR saline 10 days before drugs gavage reperfusion.Primary cells sampled from SD neonatal construct hypoxia/reoxygenation cell models.The assigned (Q) group.Except all other groups hypoxia/reoxygenation.Cells Q (10 μM, 20 40 μM) 24 h advance then measures cause hypoxia-reoxygenation injury.Cells same concentration loaded method used group.The apoptosis, infarction, ventricular remodeling, hemodynamic indexes, physiological biochemical JAK2/STAT3 pathway expression each detected, viability, oxidative stress, primary also detected.Results: significantly activated vivo vitro, intensified activation.Compared quercetin, more effective inhibiting apoptosis reducing infarction size, improving remodeling cardiac function-related promoting recovery blood flow.Conclusion: enhance activation JAK2/ STAT3 pathway, thus enhancing protection heart MIRI rats.

Language: Английский

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Plant Occurring Flavonoids as Modulators of the Aryl Hydrocarbon Receptor

Molecules, Journal Year: 2021, Volume and Issue: 26(8), P. 2315 - 2315

Published: April 16, 2021

The aryl hydrocarbon receptor (AhR) is a transcription factor deeply implicated in health and diseases. Historically identified as sensor of xenobiotics mainly toxic substances, AhR has recently become an emerging pharmacological target cancer, immunology, inflammatory conditions, aging. Multiple ligands are recognized, with plant occurring flavonoids being the largest group natural human diet. biological implications modulatory effects on could be highlighted from toxicological environmental concern for possible applicability. Overall, AhR-mediated harmful and/or beneficial need to further investigated, since many cases they contradictory. Similar other modulators, commonly exhibit tissue, organ, species-specific activities AhR. Such cellular-context dependency probably their pharmacotherapeutic use. Flavones, flavonols, flavanones, isoflavones main subclasses reported modulators. Some structural features these groups that influencing herein summarized. However, limited generalizations, well few outright structure-activity relationships can suggested agonism antagonism caused by flavonoids.

Language: Английский

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Quercetin Nanoemulsion Ameliorates Neuronal Dysfunction in Experimental Alzheimer’s Disease Model

Antioxidants, Journal Year: 2022, Volume and Issue: 11(10), P. 1986 - 1986

Published: Oct. 5, 2022

Aluminum is the most abundant metal that can get admission to human through several means include our food, drinking water, cans, drugs, and deodorants, causing neurodegenerative diseases such as Alzheimer's disease (AD). The present study aims evaluate role of quercetin nanoemulsion (QCNE) in attenuating neuronal dysfunction aluminum chloride (AlCl3)-induced experimental AD. All animals were classified into six groups including negative control group (I): received a vehicle; QC group: intraperitoneal (IP) injection QC; AlCl3 orally; treated orally IP (II): (III): QCNE. At end period (30 days), brain was used biochemical parameters (measurement neurotransmitters (serotonin, dopamine, norepinephrine), oxidant/antioxidant (reduced glutathione, malondialdehyde, superoxide dismutase, advanced oxidation protein product), inflammatory markers (adiponectin, interleukin 1β, plasma tumor necrosis factor-alpha)), while another part for immune-histochemical analysis (study cyclooxygenases (COX-1 COX-2)). Results showed mean value oxidative stress significantly increased AD well biomarkers all neurotransmitters, whereas these attenuated groups, especially those immunohistochemistry findings confirm results. Both approaches (QC QCNE) succeeded retracting impact AlCl3. Meanwhile, effect QCNE more potent mitigating mediated by animals. In conclusion, treatment mainly has huge potential protecting against AlCl3-induced dysfunction, shown results elevation antioxidant/anti-inflammatory activities neurotransmitter levels mending histopathological changes animal models.

Language: Английский

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