Antioxidants,
Journal Year:
2021,
Volume and Issue:
10(7), P. 1152 - 1152
Published: July 20, 2021
Viral
infections
constitute
a
tectonic
convulsion
in
the
normophysiology
of
hosts.
The
current
coronavirus
disease
2019
(COVID-19)
pandemic
is
not
an
exception,
and
therefore
severe
acute
respiratory
syndrome
2
(SARS-CoV-2)
infection,
like
any
other
invading
microbe,
enacts
generalized
immune
response
once
virus
contacts
body.
Melatonin
systemic
dealer
that
does
overlook
homeostasis
disturbance,
which
consequently
brings
into
play
its
cooperative
triad,
antioxidant,
anti-inflammatory,
immune-stimulant
backbone,
to
stop
infective
cycle
SARS-CoV-2
or
endogenous
exogenous
threat.
In
COVID-19,
corporal
propagation
involves
exacerbated
oxidative
activity
overproduction
great
amounts
reactive
oxygen
nitrogen
species
(RONS).
endorsement
melatonin
as
possible
protective
agent
against
indirectly
supported
by
widely
demonstrated
beneficial
role
preclinical
clinical
studies
diseases.
addition,
focusing
therapeutic
action
on
strengthening
host
protection
responses
critical
phases
makes
it
likely
multi-tasking
will
provide
multi-protection,
maintaining
efficacy
variants
are
already
emerging
emerge
long
continues
circulate
among
us.
MedComm,
Journal Year:
2023,
Volume and Issue:
4(2)
Published: April 1, 2023
Abstract
Severe
acute
respiratory
syndrome
coronavirus
2
(SARS‐CoV‐2),
a
novel
coronavirus,
causes
disease
2019
(COVID‐19)
which
led
to
neurological
damage
and
increased
mortality
worldwide
in
its
second
third
waves.
It
is
associated
with
systemic
inflammation,
myocardial
infarction,
illness
including
ischemic
strokes
(e.g.,
cardiac
cerebral
ischemia),
even
death
through
multi‐organ
failure.
At
the
early
stage,
virus
infects
lung
epithelial
cells
slowly
transmitted
other
organs
gastrointestinal
tract,
blood
vessels,
kidneys,
heart,
brain.
The
effect
of
mainly
due
hypoxia‐driven
reactive
oxygen
species
(ROS)
generated
cytokine
storm.
Internalization
SARS‐CoV‐2
triggers
ROS
production
modulation
immunological
cascade
ultimately
initiates
hypercoagulable
state
vascular
thrombosis.
Suppression
machinery
inhibition
play
an
important
role
disturbances.
So,
COVID‐19
central
nervous
system,
patients
need
special
care
prevent
failure
at
later
stages
progression.
Here
this
review,
we
are
selectively
discussing
these
issues
possible
antioxidant‐based
prevention
therapies
for
COVID‐19‐associated
that
leads
International Journal of Nanomedicine,
Journal Year:
2021,
Volume and Issue:
Volume 16, P. 6861 - 6888
Published: Oct. 1, 2021
Abstract:
Tryptophan
and
melatonin
are
pleiotropic
molecules,
each
capable
of
influencing
several
cellular,
biochemical,
physiological
responses.
Therefore,
sensitive
detection
tryptophan
in
pharmaceutical
human
samples
is
crucial
for
well-being.
Mass
spectrometry,
high-performance
liquid
chromatography,
capillary
electrophoresis
common
methods
both
analysis;
however,
these
require
copious
amounts
time,
money,
manpower.
Novel
electrochemical
optical
tools
have
been
subjects
intensive
research
due
to
their
ability
offer
a
better
signal-to-noise
ratio,
high
specificity,
ultra-sensitivity,
wide
dynamic
range.
Recently,
researchers
designed
selective
platforms
by
using
new
surface
modifications,
microfabrication
techniques,
the
decoration
diverse
nanomaterials
with
unique
properties
melatonin.
However,
there
scarcity
review
articles
addressing
recent
developments
Here,
we
provide
critical
objective
high-sensitivity
sensors
that
developed
over
past
six
years
(2015
onwards).
We
principles,
performance,
limitations
sensors.
also
address
aspects
sensitivity
selectivity,
limit
range
detection,
fabrication
process
durability,
biocompatibility.
Finally,
discuss
challenges
related
present
future
outlooks.
Keywords:
tryptophan,
melatonin,
electrochemical,
sensors,
voltammetry,
Diseases,
Journal Year:
2021,
Volume and Issue:
9(2), P. 30 - 30
Published: April 14, 2021
Exaggerated
oxidative
stress
and
hyper-inflammation
are
essential
features
of
oxidative/inflammatory
diseases.
Simultaneously,
both
processes
may
be
the
cause
or
consequence
mitochondrial
dysfunction,
thus
establishing
a
vicious
cycle
among
these
three
factors.
However,
several
natural
substances,
including
melatonin
micronutrients,
prevent
attenuate
damage
preserve
an
optimal
state
health
by
managing
general
inflammatory
status.
This
review
aims
to
describe
crucial
role
mitochondria
in
development
progression
multiple
diseases
as
well
close
relationship
stress,
cytokine
storm.
Likewise,
it
attempts
summarize
main
findings
related
powerful
effects
some
micronutrients
(vitamins
minerals),
which
useful
(alone
combination)
therapeutic
agents
treatment
examples
pathologies,
sepsis,
cardiovascular,
renal,
neurodegenerative,
metabolic
disorders.
Antioxidants,
Journal Year:
2021,
Volume and Issue:
10(7), P. 1152 - 1152
Published: July 20, 2021
Viral
infections
constitute
a
tectonic
convulsion
in
the
normophysiology
of
hosts.
The
current
coronavirus
disease
2019
(COVID-19)
pandemic
is
not
an
exception,
and
therefore
severe
acute
respiratory
syndrome
2
(SARS-CoV-2)
infection,
like
any
other
invading
microbe,
enacts
generalized
immune
response
once
virus
contacts
body.
Melatonin
systemic
dealer
that
does
overlook
homeostasis
disturbance,
which
consequently
brings
into
play
its
cooperative
triad,
antioxidant,
anti-inflammatory,
immune-stimulant
backbone,
to
stop
infective
cycle
SARS-CoV-2
or
endogenous
exogenous
threat.
In
COVID-19,
corporal
propagation
involves
exacerbated
oxidative
activity
overproduction
great
amounts
reactive
oxygen
nitrogen
species
(RONS).
endorsement
melatonin
as
possible
protective
agent
against
indirectly
supported
by
widely
demonstrated
beneficial
role
preclinical
clinical
studies
diseases.
addition,
focusing
therapeutic
action
on
strengthening
host
protection
responses
critical
phases
makes
it
likely
multi-tasking
will
provide
multi-protection,
maintaining
efficacy
variants
are
already
emerging
emerge
long
continues
circulate
among
us.
