Therapeutic and Improving Function of Lactobacilli in the Prevention and Treatment of Cardiovascular-Related Diseases: A Novel Perspective From Gut Microbiota

Frontiers in Nutrition, Journal Year: 2021, Volume and Issue: 8

Published: June 7, 2021

The occurrence and development of cardiovascular-related diseases are associated with structural functional changes in gut microbiota (GM). accumulation beneficial commensals contributes to the improvement diseases. that can be relieved by Lactobacillus supplementation, including hypercholesterolemia, atherosclerosis, myocardial infarction, heart failure, type 2 diabetes mellitus, obesity, have expanded. As probiotics, lactobacilli occupy a substantial part GM play important roles through various GM-derived metabolites. Lactobacilli ultimately impact on lipid metabolism, inflammatory factors, oxidative stress relieve symptoms However, axis cellular process commensal improving not been fully elucidated. Additionally, strains produce diverse antimicrobial peptides, which help maintain intestinal homeostasis ameliorate These field needs further investigated immediately. Thus, this review demonstrated mechanisms summarized evidence benefit strain supplementation from animal studies human clinical trials. We also highlighted broad range candidates therapeutic capability mining their Our study provides instruction as food improve

Language: Английский

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Probiotics Interact With Lipids Metabolism and Affect Gut Health

Frontiers in Nutrition, Journal Year: 2022, Volume and Issue: 9

Published: May 31, 2022

Probiotics have attracted much attention due to their ability modulate host intestinal microbe, participate in nutrient metabolism or immunomodulatory. Both inflammatory bowel disease (IBD) and cancer are digestive system disease, which become a global public health problem unclear etiology, difficult cure, repeated attacks. Disturbed gut microbiota abnormal lipid would increase the risk of inflammation. However, link between metabolism, probiotics, IBD is unclear. In this review, we found that different lipids derivatives effects on microbes. ω-3 polyunsaturated fatty acids (PUFAs) docosahexaenoic acid, eicosapentaenoic resolvin E1, D can inhibit oxidative stress reactive oxygen species activate NFκB MAPk pathway. While ω-6 PUFAs linoleic acid arachidonic be derived into leukotrienes prostaglandins, will aggravate IBD. Cholesterol converted bile promote absorption affect microbial survival colonization. At same time, it affected by salt hydrolase regulate blood lipids. Low denstiy lipoprotein (LDL) easily oxidized LDL, thereby promoting inflammation, while high (HDL) has opposite effect. compete with microorganisms for nutrients ecological sites thus structure microbiota. Moreover, short chain acids, hydrolase, superoxide dismutase, glutathione, etc. conclusion, probiotics directly indirectly involved impact IBD, provides possibility explore role improving health.

Language: Английский

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The oral microbiota and cardiometabolic health: A comprehensive review and emerging insights

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: Nov. 18, 2022

There is mounting evidence demonstrating that oral dysbiosis causes periodontal disease and promotes the development of cardiovascular disease. The advancement omics techniques has driven optimization microbiota species analysis provided a deeper understanding pathogenic bacteria. A bi-directional relationship exists between host, oral-gut transfer known to alter composition gut may cause local metabolic disorders. Furthermore, health can also be highly affected by functions metabolites, including short-chain fatty acids (SCFAs), nitric oxide (NO), hydrogen sulfide (H 2 S), some lipid metabolites. Studies have found trimethylamine (TMAO) adverse effects on health, whereas SCFAs, NO, H S cardioprotective effects. SCFAs exert varying effects, however reports this specific topic remain controversial. Previous evidences are accustomed summarizing in context periodontitis. direct diseases insufficient. By systematically methods associated with transplantation (OMT), review facilitates an investigation into causal links concomitant omics, bioinformatics, bacterial culture techniques, required gain occurrence.

Language: Английский

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Emerging Roles of Gut Microbial Modulation of Bile Acid Composition in the Etiology of Cardiovascular Diseases

Nutrients, Journal Year: 2023, Volume and Issue: 15(8), P. 1850 - 1850

Published: April 12, 2023

Despite advances in preventive measures and treatment options, cardiovascular disease (CVD) remains the number one cause of death globally. Recent research has challenged traditional risk factor profile highlights potential contribution non-traditional factors CVD, such as gut microbiota its metabolites. Disturbances have been repeatedly associated with including atherosclerosis hypertension. Mechanistic studies support a causal role microbiota-derived metabolites development, short-chain fatty acids, trimethylamine-N-oxide, bile latter being elaborately discussed this review. Bile acids represent class cholesterol derivatives that is essential for intestinal absorption lipids fat-soluble vitamins, plays an important turnover and, more recently discovered, acts group signaling molecules exerts hormonal functions throughout body. Studies shown mediating roles control lipid metabolism, immunity, heart function. Consequently, picture emerged acting integrators modulators cardiometabolic pathways, highlighting their therapeutic targets CVD. In review, we provide overview alterations acid metabolism found CVD patients, describe molecular mechanisms through which may modulate risk, discuss bile-acid-based strategies relation to

Language: Английский

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The Impact of Smoking on Microbiota: A Narrative Review

Biomedicines, Journal Year: 2023, Volume and Issue: 11(4), P. 1144 - 1144

Published: April 10, 2023

Cigarette smoke is a classic risk factor for many diseases. The microbiota has been recently indicated as new, major player in human health. Its deregulation-dysbiosis-is considered new several illnesses. Some studies highlight cross-interaction between these two factors-smoke and dysbiosis-that may explain the pathogenesis of some We searched keywords "smoking OR AND microbiota" title articles on PubMed®, UptoDate®, Cochrane®. included published English over last 25 years. collected approximately 70 articles, grouped into four topics: oral cavity, airways, gut, other organs. Smoke impair homeostasis through same harmful mechanisms exerted host cells. Surprisingly, dysbiosis its consequences affect not only those organs that are direct contact with smoke, such cavity or but also involve distant organs, heart, vessels, genitourinary tract. These observations yield deeper insight implicated smoke-related diseases, suggesting role dysbiosis. speculate modulation help prevent treat

Language: Английский

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