Impact of Gut Microbiota on the Association between Diet and Depressive Symptoms in Breast Cancer DOI Open Access
Gusonghan Maitiniyazi, Xiaoyun Cao, Yue Chen

et al.

Nutrients, Journal Year: 2022, Volume and Issue: 14(6), P. 1186 - 1186

Published: March 11, 2022

Little is known about the relationship between diet and depression through gut microbiota among breast cancer patients. This study aimed to examine dietary intake differences depressed (DBC) non-depressed (NBC) patients, whether could lead changes that affect depressive symptoms. Participants completed Center for Epidemiological Studies-Depression Scale (CES-D) 24 h recall. Fecal samples of 18 DBC patients 37 NBC were collected next-generation sequencing. A total 60 out 205 reported significant symptoms suggested by a CES-D score ≥ 16, which might be related lower intakes energy, protein, fiber, vitamin A, B2, niacin, calcium, phosphorus, potassium, iron, zinc, selenium, manganese tryptophan, poor quality indicated Chinese Healthy Eating Index (CHEI) score. Additionally, demonstrated greater diversity healthier composition, in relative abundances Proteobacteria Escherichia-Shigella both than (p < 0.05). Alpha was mediator depression, while phosphorus selenium significantly regulated independent microbiota. Breast cancer-related associated with via microbiota-dependent pathways micronutrient microbiota-independent pathways.

Language: Английский

Live and Heat-Inactivated Streptococcus thermophilus MN-ZLW-002 Mediate the Gut–Brain Axis, Alleviating Cognitive Dysfunction in APP/PS1 Mice DOI Open Access
Yujie Zhang, Yimei Wang,

Zhimo Zhou

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(6), P. 844 - 844

Published: March 15, 2024

Research on regulating brain functions with probiotics and postbiotics through the gut-brain axis is attracting attention, offering possibility of adjuvant therapy for Alzheimer's disease (AD). Three-month-old male APP/PS1 mice were gavaged live heat-inactivated S. thermophilus MN-002 three months. This study demonstrated that improved cognitive dysfunctions in mice, especially spatial memory. However, main effects directly altered intestinal microbiota composition increased serum IL-1β IL-6. Heat-inactivated colonic propionic acid levels enhanced hippocampus's antioxidant capacity. Furthermore, changes more obvious high-dose group, such as astrogliosis hippocampus. These results indicate different forms doses same strain, MN-002, can partly improve AD model via axis.

Language: Английский

Citations

6
The role of the gut microbiome and its metabolites in cerebrovascular diseases DOI Creative Commons
Hongyu Xu, Ziyue Xu, Shengrong Long

et al.

Frontiers in Microbiology, Journal Year: 2023, Volume and Issue: 14

Published: April 14, 2023

The gut microbiome is critically involved in maintaining normal physiological function the host. Recent studies have revealed that alterations contribute to development and progression of cerebrovascular disease via microbiota-gut-brain axis (MGBA). As a broad communication network human body, MGBA has been demonstrated significant interactions with various factors, such as brain structure function, nervous system diseases, etc. It also believed species composition microbiota its metabolites are intrinsically linked vascular inflammation immune responses. In fact, fecal transplantation (FMT) research, specific downstream-related proven not only participate processes but affect occurrence diseases directly or indirectly through systemic inflammatory response. Due high mortality disability rate new treatments improve intestinal dysbacteriosis gradually attracted widespread attention better ameliorate poor prognosis non-invasive way. This review summarizes latest advances research reveals profound impact dysbiosis on diseases. At same time, we elucidated molecular mechanisms whereby microbial regulate expression interleukins Moreover, further discuss feasibility novel therapeutic strategies targeting outcome patients Finally, provide insights for standardized diagnosis treatment

Language: Английский

Citations

15
Immunopathology of herpes simplex virus‐associated neuroinflammation: Unveiling the mysteries DOI
Md Sadique Hussain, Gaurav Gupta,

Vijaya Paul Samuel

et al.

Reviews in Medical Virology, Journal Year: 2023, Volume and Issue: 34(1)

Published: Nov. 20, 2023

The immunopathology of herpes simplex virus (HSV)-associated neuroinflammation is a captivating and intricate field study within the scientific community. HSV, renowned for its latent infection capability, gives rise to spectrum neurological expressions, ranging from mild symptoms severe encephalitis. enigmatic interplay between host's immune responses profoundly shapes outcome these infections. This review delves into multifaceted reactions triggered by HSV neural tissues, intricately encompassing innate adaptive immunity. Furthermore, this analysis delicate equilibrium defence potential immunopathology-induced damage. It meticulously dissects roles diverse cells, cytokines, chemokines, unravelling intricacies modulation subsequent effects. By exploring HSV's manipulation exploitation mechanisms, endeavours unveil enigmas surrounding HSV-associated neuroinflammation. comprehensive understanding enhances our grasp viral pathogenesis holds promise pioneering therapeutic strategies designed mitigate ramifications

Language: Английский

Citations

15
Difficulties in Establishing the Adverse Effects of β-Casomorphin-7 Released from β-Casein Variants—A Review DOI Creative Commons
Marta Liliane de Vasconcelos, L Oliveira, Jeremy P. Hill

et al.

Foods, Journal Year: 2023, Volume and Issue: 12(17), P. 3151 - 3151

Published: Aug. 22, 2023

β-Casomorphin-7 (BCM-7) is a peptide released through the proteolysis of β-casein (β-CN), which considered bioactive displaying evidence promoting binding and activation μ-opioid receptor located in various body parts, such as gastrointestinal tract, immune system potentially central nervous system. The possible effects BCM-7 on health are theme rising popularity due to found several studies modulation proinflammatory responses that can trigger digestive symptoms, abdominal discomfort. With advancement studies, hypothesis there correlation with microbiota–gut–brain axis has been established. However, some have suggested possibility these adverse restricted portion population, topic controversial small number vivo makes it difficult obtain more conclusive results. In addition, threshold exposure not yet established clarify potential this physiological at systemic levels. proportion population be susceptible evidenced literature review. challenges establishing discussed, including importance quantifying release different β-CN genotypes. summary, reviewed provides plausible indications relationship between A1/BCM-7 effects; however, need for further, especially better understand confirm peptide.

Language: Английский

Citations

14
Impact of Gut Microbiota on the Association between Diet and Depressive Symptoms in Breast Cancer DOI Open Access
Gusonghan Maitiniyazi, Xiaoyun Cao, Yue Chen

et al.

Nutrients, Journal Year: 2022, Volume and Issue: 14(6), P. 1186 - 1186

Published: March 11, 2022

Little is known about the relationship between diet and depression through gut microbiota among breast cancer patients. This study aimed to examine dietary intake differences depressed (DBC) non-depressed (NBC) patients, whether could lead changes that affect depressive symptoms. Participants completed Center for Epidemiological Studies-Depression Scale (CES-D) 24 h recall. Fecal samples of 18 DBC patients 37 NBC were collected next-generation sequencing. A total 60 out 205 reported significant symptoms suggested by a CES-D score ≥ 16, which might be related lower intakes energy, protein, fiber, vitamin A, B2, niacin, calcium, phosphorus, potassium, iron, zinc, selenium, manganese tryptophan, poor quality indicated Chinese Healthy Eating Index (CHEI) score. Additionally, demonstrated greater diversity healthier composition, in relative abundances Proteobacteria Escherichia-Shigella both than (p < 0.05). Alpha was mediator depression, while phosphorus selenium significantly regulated independent microbiota. Breast cancer-related associated with via microbiota-dependent pathways micronutrient microbiota-independent pathways.

Language: Английский

Citations

22