Indian Pediatrics, Journal Year: 2025, Volume and Issue: unknown
Published: March 12, 2025
Language: Английский
Advances in Nutrition, Journal Year: 2022, Volume and Issue: 13(5), P. S1 - S26
Published: May 6, 2022
The immune system is key to host defense against pathogenic organisms. Aging associated with changes in the system, a decline protective components (immunosenescence), increasing susceptibility infectious disease, and chronic elevation low-grade inflammation (inflammaging), risk of multiple noncommunicable diseases. Nutrition determinant cell function gut microbiota. In turn, microbiota shapes controls inflammatory responses. Many older people show Age-related competence, inflammation, dysbiosis may be interlinked relate, at least part, age-related nutrition. A number micronutrients (vitamins C, D, E zinc selenium) play roles supporting many types. Some trials report that providing these as individual supplements can reverse deficits and/or those insufficient intakes. There inconsistent evidence this will reduce or severity infections including respiratory infections. Probiotic, prebiotic, synbiotic strategies modulate microbiota, especially by promoting colonization lactobacilli bifidobacteria, have been demonstrated some biomarkers and, cases, gastrointestinal infections, although, again, inconsistent. Further research well-designed well-powered at-risk populations required more certain about role modify microbiota-host relationship protecting infection, infection.
Language: Английский
Citations
77
Seminars in Immunopathology, Journal Year: 2025, Volume and Issue: 47(1)
Published: Jan. 22, 2025
Language: Английский
Citations
4
Journal of Personalized Medicine, Journal Year: 2022, Volume and Issue: 12(1), P. 66 - 66
Published: Jan. 7, 2022
Asthma is a complex multifactorial and heterogeneous respiratory disease. Although genetics strong risk factor of asthma, external internal exposures their interactions with genetic factors also play important roles in the pathophysiology asthma. Over past decades, application high-throughput omics approaches has emerged been applied to field asthma research for screening biomarkers such as genes, transcript, proteins, metabolites an unbiased fashion. Leveraging large-scale studies representative diverse population-based data integrating clinical led better profiling risk. Yet, date, no omic-driven endotypes have translated into practice management In this article, we provide overview current status namely, genomics, transcriptomics, epigenomics, proteomics, exposomics, metabolomics. The development multi-omics integrations briefly discussed. Biomarker discovery following could be challenging but useful disease phenotyping endotyping that can translate advances care, ultimately leading successful precision medicine approaches.
Language: Английский
Citations
45
Archives of Dermatological Research, Journal Year: 2025, Volume and Issue: 317(1)
Published: Jan. 16, 2025
Language: Английский
Citations
1
Indian Pediatrics, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 28, 2025
Language: Английский
Citations
1
Nutrients, Journal Year: 2022, Volume and Issue: 14(9), P. 1825 - 1825
Published: April 27, 2022
We are currently riding the second wave of allergy epidemic, which is ongoing in affluent societies, but now also affecting developing countries. This increase prevalence atopy/asthma Western world has coincided with a rapid improvement living conditions and radical changes lifestyle, suggesting that this upward trend allergic manifestations may be associated cultural environmental factors. Diet prominent exposure undergone major changes, substantial consumption processed foods, all across globe. On basis, potential effects dietary habits on atopy asthma have been researched rigorously, even considerable body evidence, clear associations far from established. Many factors converge to obscure relationship, including methodological, pathophysiological differences. To date, most commonly researched, highly promising, candidate for exerting protective effect so-called Mediterranean diet (MedDi). pattern subject investigation since mid twentieth century, evidence regarding its beneficial health overwhelming, although data correlation between MedDi incidence severity inconclusive. As appears lower some populations, it can speculated could indeed place preventive strategy asthma/atopy. review current constituents asthma/atopy, emphasis links disease outcomes research pitfalls methodological caveats hinder identification causality. MedDi, as pattern, rather than short-term supplementation or excessive focus single nutrient effects, rational option intervention against asthma.
Language: Английский
Citations
29
Life, Journal Year: 2024, Volume and Issue: 14(4), P. 447 - 447
Published: March 28, 2024
Microalgae can convert carbon dioxide into organic matter through photosynthesis. Thus, they are considered as an environment-friendly and efficient cell chassis for biologically active metabolites. Microalgal lipids a class of compounds that be used raw materials food, feed, cosmetics, healthcare products, bioenergy, etc., with tremendous potential commercialization. In this review, we summarized the commercial lipid products from eukaryotic microalgae, updated mechanisms synthesis in microalgae. Moreover, reviewed enhancement lipids, triglycerides, polyunsaturated fatty acids, pigments, terpenes microalgae via environmental induction and/or metabolic engineering past five years. Collectively, provided comprehensive overview biosynthesis, induced strategies genetic microalgal lipids. Meanwhile, outlook has been presented development industries, emphasizing significance accurate analysis bioactivity, well high-throughput screening specific
Language: Английский
Citations
8
Nature Metabolism, Journal Year: 2024, Volume and Issue: 6(5), P. 899 - 913
Published: April 1, 2024
Language: Английский
Citations
7
Molecules and Cells, Journal Year: 2024, Volume and Issue: 47(2), P. 100010 - 100010
Published: Jan. 21, 2024
Recently, the incidence of metabolic dysfunction-associated steatotic liver disease (MASLD) is increasing due to high prevalence conditions, such as obesity and type 2 diabetes mellitus. Steatotic a hotspot for cancer metastasis in MASLD. Altered lipid metabolism, hallmark MASLD, remodels tissue microenvironment, making it conducive growth metastatic cancer. Tumors exacerbate dysregulation hepatic metabolism by releasing extracellular vesicles particles into liver. influences proliferation, differentiation, functions immune cells, contributing formation an immunosuppressive metastasis-prone microenvironment This review discusses mechanisms which promotes progression, focusing on its role fostering Furthermore, this highlights manipulation strategies therapeutic management
Language: Английский
Citations
6
The Pediatric Infectious Disease Journal, Journal Year: 2024, Volume and Issue: 43(11), P. 1090 - 1099
Published: July 5, 2024
Acute respiratory infections (ARIs) affect the tract, are often caused by viruses such as syncytial virus and rhinovirus, present symptoms coughing, fever, distress, breathing difficulty. The global adherence to exclusive breastfeeding (BF) for first 6 months of life has reached 44%, supported World Health Organization United Nations International Children's Emergency Fund efforts. BF provides vital nutrients contributes infant immune system development, protecting against infections. role in preventing reducing complications ARIs infants is gaining attention, prompting a review current data future research needs. This aims summarize evidence on risk severity infants, elucidate adaptations breast milk composition during infections, identify relevant
Language: Английский
Citations
6