Journal of Attention Disorders,
Journal Year:
2022,
Volume and Issue:
26(13), P. 1698 - 1710
Published: Jan. 20, 2022
Objective:
The
main
goal
of
this
systematic
review
is
to
summarize
evidences
regarding
alterations
microbial
composition
in
ADHD
cases
and
uncover
underlying
mechanisms.
Methods:
A
comprehensive
search
was
conducted
on
PubMed,
Web
Science,
Scopus
databases
up
March
2021.
All
the
observational
studies
including
case-control,
cross-sectional,
cohorts
investigating
correlations
between
gut
microbiota
both
adults
children
were
included.
Results:
We
found
eight
eligible
studies.
Enterococcus,
Bifidobacterium,
Odoribacter
increased
which
may
lead
impaired
dopamine
related
functions
CNS.
Moreover,
decrease
Faecalibacterium
frequency
could
result
higher
permeability
crossing
inflammatory
cytokines.
Regarding
short
chain
fatty
acids-producing
bacteria,
Ruminococcaceae
family
decreased
Bacteroides
uniformis
ovatus
species
increased.
Conclusion:
Gut
correlation
with
its
mechanisms
open
new
windows
for
developing
novel
therapies
by
manipulating
microbiota.
Journal of Child Psychology and Psychiatry,
Journal Year:
2023,
Volume and Issue:
64(9), P. 1280 - 1291
Published: April 5, 2023
Background
Dysbiosis
in
the
gut
microbial
community
might
be
involved
pathophysiology
of
attention‐deficit/hyperactivity
disorder
(ADHD).
The
fungal
component
microbiome,
namely
mycobiota,
is
a
hyperdiverse
group
multicellular
eukaryotes
that
can
influence
host
intestinal
permeability.
This
study
therefore
aimed
to
investigate
impact
mycobiome
dysbiosis
and
permeability
on
ADHD.
Methods
Faecal
samples
were
collected
from
35
children
with
ADHD
healthy
controls.
Total
DNA
was
extracted
faecal
internal
transcribed
spacer
regions
sequenced
using
high‐throughput
next‐generation
sequencing
(NGS).
taxonomic
classification
analysed
bioinformatics
tools
differentially
expressed
species
between
control
groups
identified.
An
vitro
assay
(Caco‐2
cell
layer)
used
evaluate
biological
effects
epithelial
barrier
function.
Results
β‐diversity
(the
diversity
two
communities
),
but
not
α‐diversity
within
community),
reflected
differences
composition
groups.
At
phylum
level,
displayed
significantly
higher
abundance
Ascomycota
lower
Basidiomycota
than
group.
genus
Candida
(especially
albicans
)
increased
patients
compared
In
addition,
revealed
C.
secretions
enhanced
Caco‐2
cells.
Conclusions
current
first
explore
altered
NGS
platform
findings
this
indicated
associated
susceptibility
European Journal of Clinical Nutrition,
Journal Year:
2023,
Volume and Issue:
77(9), P. 855 - 871
Published: Feb. 14, 2023
Abstract
Gut
dysbiosis
is
associated
with
sepsis
and
necrotizing
enterocolitis
in
preterm
infants,
which
can
adversely
affect
long-term
growth
neurodevelopment.
We
aimed
to
synthesise
evidence
for
the
effect
of
probiotic
supplementation
on
neurodevelopmental
outcomes
infants.
MEDLINE,
EMBASE,
EMCARE,
Cochrane
CENTRAL,
grey
literature
were
searched
February
2022.
Only
randomized
controlled
trials
(RCTs)
included.
Meta-analysis
was
performed
using
random
effects
model.
Effect
sizes
expressed
as
standardized
mean
difference
(SMD),
(MD)
or
risk
ratio
(RR)
their
corresponding
95%
confidence
intervals
(CI).
Risk
Bias
(ROB)
assessed
ROB-2
tool.
Certainty
Evidence
(CoE)
summarized
GRADE
guidelines.
Thirty
RCTs
(
n
=
4817)
showed
that
better
short-term
weight
gain
[SMD
0.24
(95%CI
0.04,
0.44);
22
3721);
p
0.02;
I
2
88%;
CoE:
low].
However,
length
0.12
−0.13,
0.36);
7
RCTs,
899);
0.35;
69%;
low]
head
circumference
0.09
−0.15,
0.34);
8
1132);
0.46;
76%;
similar
between
placebo
groups.
Probiotic
had
no
impairment
[RR
0.91
0.76,
1.08);
5
1556);
0.27;
0%;
gain,
but
did
not
length,
circumference,
growth,
Adequately
powered
are
needed
this
area.
Prospero
Registration:
CRD42020064992.
FEMS Microbiology Letters,
Journal Year:
2023,
Volume and Issue:
370
Published: Jan. 1, 2023
Abstract
Aggression
is
a
complex
psychological
program
that
influenced
by
genetics,
environment,
and
history.
Research
has
shown
the
hormonal
levels
in
body
development
of
brain
can
be
major
predictors
aggression.
This
review
highlights
recent
studies
have
connected
gut
microbiome
to
alterations
hormones
how
this
impact
paper
also
provides
systematic
on
directly
assess
connection
between
aggression
reviews
these
connections
relation
age.
We
conclude
with
future
directions
are
needed
further
determine
link
among
adolescents.
Journal of Attention Disorders,
Journal Year:
2022,
Volume and Issue:
26(13), P. 1698 - 1710
Published: Jan. 20, 2022
Objective:
The
main
goal
of
this
systematic
review
is
to
summarize
evidences
regarding
alterations
microbial
composition
in
ADHD
cases
and
uncover
underlying
mechanisms.
Methods:
A
comprehensive
search
was
conducted
on
PubMed,
Web
Science,
Scopus
databases
up
March
2021.
All
the
observational
studies
including
case-control,
cross-sectional,
cohorts
investigating
correlations
between
gut
microbiota
both
adults
children
were
included.
Results:
We
found
eight
eligible
studies.
Enterococcus,
Bifidobacterium,
Odoribacter
increased
which
may
lead
impaired
dopamine
related
functions
CNS.
Moreover,
decrease
Faecalibacterium
frequency
could
result
higher
permeability
crossing
inflammatory
cytokines.
Regarding
short
chain
fatty
acids-producing
bacteria,
Ruminococcaceae
family
decreased
Bacteroides
uniformis
ovatus
species
increased.
Conclusion:
Gut
correlation
with
its
mechanisms
open
new
windows
for
developing
novel
therapies
by
manipulating
microbiota.
