Nutrients,
Journal Year:
2021,
Volume and Issue:
13(11), P. 3680 - 3680
Published: Oct. 20, 2021
Vitamin
D
has
many
effects
on
cells
in
the
immune
system.
Many
studies
have
linked
low
vitamin
status
with
severity
of
COVID-19.
Genetic
variants
involved
metabolism
been
implicated
as
potential
risk
factors
for
severe
COVID-19
outcomes.
This
study
investigated
how
genetic
variations
humans
affected
clinical
presentation
In
total,
646
patients
SARS-CoV-2
infection
were
divided
into
two
groups:
noncritical
(
Nutrients,
Journal Year:
2022,
Volume and Issue:
14(3), P. 464 - 464
Published: Jan. 21, 2022
Laboratory
evidence
provides
a
biological
rationale
for
the
benefits
of
vitamin
D
in
COVID-19,
and
supplementation
is
associated
with
reduced
risk
respiratory
infections.
Most
clinical
studies
COVID-19
have
been
observational,
most
serious
problem
observational
study
design
that
confounding.
Observational
typically
assess
relationship
25(OH)D
values
outcomes.
Many
conditions
low
status
are
also
worse
Randomized
controlled
trials
(RCTs)
overcome
confounding,
comparing
outcomes
between
groups
receiving
or
placebo.
However,
any
benefit
may
be
related
to
dose,
duration,
daily
vs.
bolus
administration,
interaction
other
treatments,
timing
administration
prior
during
illness.
Serum
>50
nmol/L
infection
rates,
severity
mortality
studies.
Few
RCTs
completed,
they
shown
no
hospitalized
patients.
Vitamin
those
mild
asymptomatic
greater
lower
acquiring
infection.
Because
at
greatest
deficiency,
it
reasonable
recommend
15−20
mcg
(600−800
IU)
general
population
pandemic.
doses
than
100
(4000
should
not
used
without
monitoring
serum
calcium.
Naunyn-Schmiedeberg s Archives of Pharmacology,
Journal Year:
2022,
Volume and Issue:
396(4), P. 607 - 620
Published: Dec. 12, 2022
Abstract
Coronavirus
disease
2019
(COVID-19)
has
a
wide-ranging
spectrum
of
clinical
symptoms,
from
asymptomatic/mild
to
severe.
Recent
research
indicates
that,
among
several
factors,
low
vitamin
D
level
is
modifiable
risk
factor
for
COVID-19
patients.
This
study
aims
evaluate
the
effect
on
hospital
and
laboratory
outcomes
patients
with
COVID-19.
Five
databases
(PubMed,
Embase,
Scopus,
Web
Science,
Cochrane
Library)
clinicaltrials.gov
were
searched
until
July
2022,
using
relevant
keywords/Mesh
terms.
Only
randomized
trials
(RCTs)
that
addressed
topic
included.
The
tool
was
used
assess
studies’
bias,
data
analyzed
review
manager
(RevMan
5.4).
We
included
nine
RCTs
1586
confirmed
Vitamin
group
showed
significant
reduction
intensive
care
unit
(ICU)
admission
(risk
ratio
=
0.59,
95%
confidence
interval
(CI)
[0.41,
0.84],
P
0.003),
higher
change
in
(standardized
mean
difference
2.27,
CI
[2.08,
2.47],
<
0.00001)
compared
control
group.
Other
studied
non-significant
between
(
≥
0.05).
In
conclusion,
reduced
ICU
superiority
changing
However,
other
no
two
groups.
More
are
needed
confirm
these
results.
Nutrients,
Journal Year:
2025,
Volume and Issue:
17(3), P. 599 - 599
Published: Feb. 6, 2025
Clinical
trials
consistently
demonstrate
an
inverse
correlation
between
serum
25-hydroxyvitamin
D
[25(OH)D;
calcifediol]
levels
and
the
risk
of
symptomatic
SARS-CoV-2
disease,
complications,
mortality.
This
systematic
review
(SR),
guided
by
Bradford
Hill’s
causality
criteria,
analyzed
294
peer-reviewed
manuscripts
published
December
2019
November
2024,
focusing
on
plausibility,
consistency,
biological
gradient.
Evidence
confirms
that
cholecalciferol
(D3)
calcifediol
significantly
reduce
hospitalizations,
mortality,
with
optimal
effects
above
50
ng/mL.
While
vitamin
requires
3–4
days
to
act,
shows
within
24
h.
Among
329
trials,
only
11
(3%)
showed
no
benefit
due
flawed
designs.
At
USD
2/patient,
D3
supplementation
is
far
cheaper
than
hospitalization
costs
more
effective
standard
interventions.
SR
establishes
a
strong
relationship
25(OH)D
vulnerability,
meeting
criteria.
Vitamin
infections,
deaths
~50%,
outperforming
all
patented,
FDA-approved
COVID-19
therapies.
With
over
300
confirming
these
findings,
waiting
for
further
studies
unnecessary
before
incorporating
them
into
clinical
protocols.
Health
agencies
scientific
societies
must
recognize
significance
results
incorporate
prophylaxis
early
treatment
protocols
similar
viral
infections.
Promoting
safe
sun
exposure
adequate
communities
maintain
40
ng/mL
(therapeutic
range:
40–80
ng/mL)
strengthens
immune
systems,
reduces
hospitalizations
deaths,
lowers
healthcare
costs.
When
exceed
70
ng/mL,
taking
K2
(100
µg/day
or
800
µg/week)
alongside
helps
direct
any
excess
calcium
bones.
The
recommended
dosage
(approximately
IU/kg
body
weight
non-obese
adult)
50–100
cost-effective
disease
prevention,
ensuring
health
outcomes.
Pathogens,
Journal Year:
2025,
Volume and Issue:
14(3), P. 263 - 263
Published: March 7, 2025
Viral
infections
have
been
a
severe
challenge
for
global
public
health,
and
viral
pneumonia
is
becoming
increasingly
critical
in
the
post-pandemic
era.
Observational
basic
studies
demonstrated
strong
link
between
host
nutrient
status
anti-viral
immune
responses,
nutritional
supplements
were
shown
to
improve
prognosis
of
infectious
diseases.
However,
there
limited
research
on
relationship
essential
micronutrients
susceptibility
pneumonia.
In
addition,
current
are
often
confounded
by
biases
reverse
causality,
undermining
their
reliability.
this
study,
fill
gap,
we
employed
Mendelian
randomization
investigate
causal
supplementation
vitamins
minerals
Our
analysis
found
that
vitamin
B6
protective
factor
against
pneumonia,
while
selenium
risk
factor.
These
findings
provide
insights
use
dietary
prevention
control
especially
when
micronutrient
used
as
an
adjunctive
therapy
infections.
Nutrients,
Journal Year:
2021,
Volume and Issue:
13(11), P. 3680 - 3680
Published: Oct. 20, 2021
Vitamin
D
has
many
effects
on
cells
in
the
immune
system.
Many
studies
have
linked
low
vitamin
status
with
severity
of
COVID-19.
Genetic
variants
involved
metabolism
been
implicated
as
potential
risk
factors
for
severe
COVID-19
outcomes.
This
study
investigated
how
genetic
variations
humans
affected
clinical
presentation
In
total,
646
patients
SARS-CoV-2
infection
were
divided
into
two
groups:
noncritical
(
