Biomedicine & Pharmacotherapy,
Journal Year:
2022,
Volume and Issue:
150, P. 112965 - 112965
Published: April 14, 2022
Main
cause
of
severe
illness
and
death
in
COVID-19
patients
appears
to
be
an
excessive
but
ineffectual
inflammatory
immune
response
that
may
acute
respiratory
distress
syndrome
(ARDS).
Vitamin
D
favour
anti-inflammatory
environment
improve
cytotoxic
against
some
infectious
diseases.
A
multicenter,
single-blind,
prospective,
randomized
clinical
trial
was
approved
with
pneumonia
levels
25-hydroxyvitamin
(25(OH)D)
14.8
ng/ml
(SD:
6.18)
test
antiviral
efficacy,
tolerance
safety
10,000
IU/day
cholecalciferol
(vitamin
Life,
Journal Year:
2025,
Volume and Issue:
15(1), P. 113 - 113
Published: Jan. 16, 2025
The
COVID-19
pandemic
caused
by
Severe
Acute
Respiratory
Syndrome
Coronavirus
2
(SARS-CoV-2)
has
profoundly
impacted
global
health,
with
pneumonia
emerging
as
a
major
complication
in
severe
cases.
pathogenesis
of
is
marked
the
overproduction
reactive
oxygen
species
(ROS)
and
an
excessive
inflammatory
response,
resulting
oxidative
stress
significant
tissue
damage,
particularly
respiratory
system.
Antioxidants
have
garnered
considerable
attention
for
their
potential
role
managing
mitigating
modulating
immune
responses.
This
review
provides
comprehensive
overview
literature
on
use
antioxidants
hospitalized
patients
mild-to-moderate
COVID-19.
Studies
exploring
antioxidants,
including
vitamins,
trace
elements,
nitric
oxide
(NO),
ozone
(O3),
glutathione
(GSH),
L-carnitine,
melatonin,
bromelain,
N-acetylcysteine
(NAC),
numerous
polyphenols,
yielded
promising
outcomes.
Through
ROS-scavenging
properties,
these
molecules
support
endothelial
function,
reduce
thrombosis
risk,
may
help
mitigate
effects
cytokine
storm,
key
contributor
to
morbidity
mortality.
Clinical
evidence
suggests
that
antioxidant
supplementation
improve
patient
outcomes
decreasing
inflammation,
supporting
cell
potentially
shortening
recovery
times.
Furthermore,
symptoms
exerting
direct
antiviral
inhibit
infection
process
genomic
replication
SARS-CoV-2
host
cells.
Moreover,
work
synergistically
standard
treatments
viral-induced
damage.
By
integrating
findings
from
real-world
data
our
clinical
experience,
we
gain
more
profound
understanding
pneumonia.
Further
research
combining
reviews
analysis
crucial
validate
efficacy
establish
evidence-based
guidelines
practice.
International Journal of Molecular Sciences,
Journal Year:
2021,
Volume and Issue:
22(19), P. 10559 - 10559
Published: Sept. 29, 2021
The
novel
coronavirus
severe
acute
respiratory
syndrome
(SARS-CoV-2)
has
progressed
rapidly
from
an
outbreak
to
a
global
pandemic,
with
new
variants
emerging.
Coronavirus
disease
2019
(COVID-19),
the
resulting
SARS-CoV-2
infection,
can
lead
multiorgan
damage.
Due
extremely
contagious
and
fatal
nature
of
virus,
it
been
priority
medical
research
find
effective
means
treatment.
Amid
this
search,
role
vitamin
D
in
modulating
various
aspects
innate
adaptive
immune
system
discussed.
This
review
aims
consolidate
surrounding
treatment
prevention
COVID-19.
While
there
are
some
conflicting
results
reported,
consensus
is
that
host
immunomodulatory
effects
which
may
be
beneficial
context
COVID-19
low
levels
result
dysfunction
crucial
antimicrobial
effects,
potentially
contributing
poor
prognosis.
Studies
also
show
mitigated
via
supplementation,
although
benefits
supplementation
remain
controversial.
Biomedicines,
Journal Year:
2021,
Volume and Issue:
9(11), P. 1714 - 1714
Published: Nov. 18, 2021
The
immune
response
to
vaccination
with
SARS-CoV-2
vaccines
varies
greatly
from
person
person.
In
addition
age,
there
is
evidence
that
certain
micronutrients
influence
the
system,
particularly
vitamin
D.
Here,
we
analysed
IgG
and
neutralisation
potency
along
25-hydroxy-cholecalciferol
[25(OH)D]
concentrations
in
a
cohort
of
healthy
German
adults
time
over
24
weeks.
Contrary
our
expectations,
no
significant
differences
were
found
dynamic
increase
or
decrease
as
function
25(OH)D
status.
Furthermore,
first
second
vaccination,
maximum
achieved,
decline
not
related
We
conclude
response,
measured
concentration,
does
depend
on
status
moderate
D
Biomedicine & Pharmacotherapy,
Journal Year:
2022,
Volume and Issue:
150, P. 112965 - 112965
Published: April 14, 2022
Main
cause
of
severe
illness
and
death
in
COVID-19
patients
appears
to
be
an
excessive
but
ineffectual
inflammatory
immune
response
that
may
acute
respiratory
distress
syndrome
(ARDS).
Vitamin
D
favour
anti-inflammatory
environment
improve
cytotoxic
against
some
infectious
diseases.
A
multicenter,
single-blind,
prospective,
randomized
clinical
trial
was
approved
with
pneumonia
levels
25-hydroxyvitamin
(25(OH)D)
14.8
ng/ml
(SD:
6.18)
test
antiviral
efficacy,
tolerance
safety
10,000
IU/day
cholecalciferol
(vitamin
