The macrophage polarization in inflammatory dermatosis and its potential drug candidates

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 161, P. 114469 - 114469

Published: March 2, 2023

Inflammatory dermatosis is characterized by persistent inflammatory infiltration and hard repair of diseased skin. As a member the human innate immune cells, macrophages usually show different phenotypes in diseases. The macrophage phenotype (M1/M2) imbalance caused increase M1 or decrease M2 common dermatosis. In recent years, with deepening research on skin diseases, more natural medicines/traditional Chinese medicines (TCMs), represented Shikonin Angelica Dahurica, have shown their therapeutic effects affecting polarization macrophages. This review introduced dermatosis, such as psoriasis. Then summarized medicines/TCMs that potential so far mechanisms action proteins/signal pathways involved. We found TCMs listed this are closely related to theory five flavors four properties medicinal, most them bitter, acrid sweet. Bitter antipyretic, anti-inflammatory antibacterial effects, which may improve inflammation infiltration. Acrid effect promoting blood circulation, while sweet nourishing. These 2 accelerate lesions conclusion, we hope provide sufficient knowledge for medicine development imbalance.

Language: Английский

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Bioactive limonoids from Carapa guianensis seeds oil and the sustainable use of its by-products

Current Research in Toxicology, Journal Year: 2023, Volume and Issue: 4, P. 100104 - 100104

Published: Jan. 1, 2023

Carapa guianensis (Andiroba, Meliaceae) is considered a multipurpose tree. In Brazil, Indigenous people have used it as insect repellent and in the treatment of various diseases. Most biological activities popular uses are attributed to limonoids, which highly oxygenated tetranortriterpenoids. More than 300 limonoids been described Meliaceae family. Limonoids from Andiroba oil shown high anti-inflammatory anti-allergic vivo, by inhibiting platelet activating factors many inflammatory mediators such IL-5, IL-1β TNF-α. It also reduced T lymphocytes, eosinophils mast cells. corroboration with wide use oil, no significant cytotoxicity or genotoxicity vivo was reported. This promotes apoptosis gastric cancer cell line (ACP02) at concentrations, without showing mutagenic effects, suggested increase body's nonspecific resistance adaptive capacity stressors, exhibit some antioxidant activity, protect against oxidative DNA damages. Recently, new methodologies toxicological assays applied. They include chemico, vitro, silico ex procedures, take place substitute laboratory animals. by-products sustainable production processes fertilizers soil conditioners, raw material for soap production, biodegradable surfactants an alternative natural source polymer order reduce environmental impacts. review reinforces relevance highlights its ability add value minimize possible risks health Amazonian population.

Language: Английский

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Nootropic Herbs, Shrubs, and Trees as Potential Cognitive Enhancers

Plants, Journal Year: 2023, Volume and Issue: 12(6), P. 1364 - 1364

Published: March 18, 2023

Plant-based nootropics are a diverse group of natural drugs that can improve cognitive abilities through various physiological mechanisms, especially in cases where these functions weakened or impaired. In many cases, the enhance erythrocyte plasticity and inhibit aggregation, which improves blood’s rheological properties increases its flow to brain. Many formulations possess antioxidant activity protects brain tissue from neurotoxicity brain’s oxygen supply. They induce synthesis neuronal proteins, nucleic acids, phospholipids for constructing repairing neurohormonal membranes. These compounds potentially be present great variety herbs, shrubs, even some trees vines. The plant species reviewed here were selected based on availability verifiable experimental data clinical trials investigating potential nootropic effects. Original research articles, relevant animal studies, meta-analyses, systematic reviews, included this review. Selected representatives heterogeneous Bacopa monnieri (L.) Wettst., Centella asiatica Urban, Eleutherococcus senticosus (Rupr. & Maxim.) Maxim., Ginkgo biloba L., Lepidium meyenii Walp., Panax ginseng C.A. Meyer, Paullinia cupana Kunth, Rhodiola rosea Schisandra chinensis (Turcz.) Baill., Withania somnifera Dunal. depicted described, together with their active components effects, evidence efficacy is presented. study provides brief descriptions representative species, occurrence, history, chemical composition principle medicinal compounds, uses, indications, treatments, dosages, possible side contraindications. Most must taken at optimal doses extended periods before measurable improvement occurs, but they generally very well tolerated. Their psychoactive not produced by single molecule synergistic combination several compounds. available suggest including extracts plants products treat disorders have substantial therapeutic benefits.

Language: Английский

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Pharmacological functions of salidroside in renal diseases: facts and perspectives

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 8, 2024

Rhodiola rosea is a valuable functional medicinal plant widely utilized in China and other Asian countries for its anti-fatigue, anti-aging, altitude sickness prevention properties. Salidroside, most active constituent derived from , exhibits potent antioxidative, hypoxia-resistant, anti-inflammatory, anticancer, anti-aging effects that have garnered significant attention. The appreciation of the pharmacological role salidroside has burgeoned over last decade, making it beneficial option treatment multiple diseases, including atherosclerosis, Alzheimer’s disease, Parkinson’s cardiovascular more. With renoprotective effects, parallel with inhibition oxidative stress inflammation, holds promise as potential therapeutic agent kidney damage. This article provides an overview microinflammatory state disease discuss current strategies, particular focus on highlighting recent advancements utilizing renal disease. mechanisms action are primarily associated regulation gene protein expression glomerular endothelial cells, podocytes, tubule mesangial cells cell carcinoma cell, TNF-α, TGF-β, IL-1β, IL-17A, IL-6, MCP-1, Bcl-2, VEGF, ECM protein, caspase-3, HIF-1α, BIM, well modulation AMPK/SIRT1, Nrf2/HO-1, Sirt1/PGC-1α, ROS/Src/Cav-1, Akt/GSK-3β, TXNIP-NLRP3, ERK1/2, TGF-β1/Smad2/3, PI3K/Akt, Wnt1/Wnt3a β-catenin, TLR4/NF-κB, MAPK, JAK2/STAT3, SIRT1/Nrf2 pathways. To best our knowledge, this review first to comprehensively cover protective diverse suggests great be developed drug metabolic syndrome, cerebrovascular diseases complications.

Language: Английский

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Anti-Neuroinflammatory Effects of Adaptogens: A Mini-Review

Molecules, Journal Year: 2024, Volume and Issue: 29(4), P. 866 - 866

Published: Feb. 15, 2024

Introduction: Adaptogens are a group of plants that exhibit complex, nonspecific effects on the human body, increasing its ability to adapt, develop resilience, and survive in stress conditions. They found many traditional medicinal systems play key role restoring body’s strength stamina. Research recent years has attempted elucidate mechanisms behind their pharmacological effects, but it appears these difficult define precisely involve multiple molecular pathways. Neuroinflammation: In years, chronic inflammation been recognized as one common features central nervous system disorders (dementia other neurodegenerative diseases, depression, anxiety, ischemic stroke, infections). Because specific nature brain, this process is called neuroinflammation, suppression can result an improvement patients’ condition may promote recovery. anti-inflammatory agents: As discovered, adaptogens display which suggests application be broader than previously thought. regulate gene expression anti- proinflammatory cytokines (prostaglandins, leukotriens) modulate signaling pathways (e.g., NF-κB). Aim: This mini-review aims present anti-neuroinflammatory potential most important classified adaptogens: Schisandra chinensis, Eleutherococcus senticosus, Rhodiola rosea Withania somnifera.

Language: Английский

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L-Arginine and Nitric Oxide in Vascular Regulation—Experimental Findings in the Context of Blood Donation

Nutrients, Journal Year: 2025, Volume and Issue: 17(4), P. 665 - 665

Published: Feb. 13, 2025

This narrative review provides an analysis of the role nitric oxide (NO) and its precursors, particularly L-arginine, in vascular regulation health, with emphasis on findings from our experimental research animal models. NO serves as a critical mediator function, contributing to vasodilation, blood flow, prevention thrombosis. As primary precursor NO, L-arginine is essential for maintaining endothelial integrity, modulating mitochondrial reducing oxidative damage. synthesises data contextualises these within physiological challenges faced by donors, such repeated donation associated stress. It examines effects supplementation respiration, lipid peroxidation, microsomal oxidation different conditions, including differences age, gender, dietary interventions. The mechanisms which enhances production, improves elasticity, alleviates dysfunction caused reduced bioavailability are also investigated. By integrating insights existing literature, this perspective potential address specific needs donors. highlights importance personalised nutritional approaches enhancing donor recovery resilience. In addition, assesses wider implications mitigating stress preserving function. interplay between bioavailability, factors, adaptation donors highlighted, along identification current knowledge gaps recommendations future research. presenting both original evidence synthesis article therapeutic promoting health context donation.

Language: Английский

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Comparison between the Biological Active Compounds in Plants with Adaptogenic Properties (Rhaponticum carthamoides, Lepidium meyenii, Eleutherococcus senticosus and Panax ginseng)

Plants, Journal Year: 2021, Volume and Issue: 11(1), P. 64 - 64

Published: Dec. 26, 2021

In the 1960s, research into plant adaptogens began. Plants with adaptogenic properties have rich phytochemical compositions and been used by humanity since ancient times. However, it is not still clear whether are because of specific compounds or whole extracts. The aim this review to compare bioactive in different parts these plants.

Language: Английский

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Herb–Drug Interaction in Inflammatory Diseases: Review of Phytomedicine and Herbal Supplements

Journal of Clinical Medicine, Journal Year: 2022, Volume and Issue: 11(6), P. 1567 - 1567

Published: March 12, 2022

Many people worldwide use plant preparations for medicinal purposes. Even in industrialized regions, such as Europe, where conventional therapies are accessible the majority of patients, there is a growing interest and usage phytomedicine. Plant not only used alternative treatment, but also combined with drugs. These combinations deserve careful contemplation, complex mixtures bioactive substances plants show potential interactions. Induction CYP enzymes pGP by St John's wort may be most famous example, much more to consider. In this review, we shed light on what known about interactions between botanicals drugs, order make practitioners aware drug-related problems. The main focus article treatment inflammatory diseases, accompanied Europe. Several drugs discuss here, basal medication chronic diseases (e.g., methotrexate, janus kinase inhibitors), oral tumor therapeutics.

Language: Английский

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Rhodiola rosea and salidroside commonly induce hormesis, with particular focus on longevity and neuroprotection

Chemico-Biological Interactions, Journal Year: 2023, Volume and Issue: 380, P. 110540 - 110540

Published: May 10, 2023

Language: Английский

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Ecdysterone and Turkesterone—Compounds with Prominent Potential in Sport and Healthy Nutrition

Nutrients, Journal Year: 2024, Volume and Issue: 16(9), P. 1382 - 1382

Published: May 2, 2024

The naturally occurring compounds ecdysterone and turkesterone, which are present in plants, including Rhaponticum carthamoides Willd. (Iljin), Spinacia oleracea L., Chenopodium quinoa Willd., Ajuga turkestanica (Regel) Briq, widely recognized due to their possible advantages for both general health athletic performance. current review investigates the beneficial biological effects of turkesterone nutrition, highlighting roles not only enhancing performance but also management various problems. Plant-based diets, associated with benefits environmental sustainability, often include sources rich phytoecdysteroids. However, therapeutic potential phytoecdysteroid-rich extracts extends beyond sports promising applications treating chronic fatigue, cardiovascular diseases, neurodegenerative disorders.

Language: Английский

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