Human Milk Feeding in Inherited Metabolic Disorders: A Systematic Review of Growth, Metabolic Control, and Neurodevelopment Outcomes

Journal of Inherited Metabolic Disease, Journal Year: 2025, Volume and Issue: 48(2)

Published: Feb. 6, 2025

ABSTRACT Human milk (HM) is the optimal source of nutrition for infants. Yet suitability HM macronutrient composition, paired with challenge regulating intake, may deserve some consideration infants inherited metabolic disorders (IMDs) requiring restrictive and controlled dietary management. Except classic galactosemia, feeding expected to be feasible, allowing maintain stability, while growing developing optimally. However, information about in nonphenylketonuria (PKU) literature scarce. In this systematic review, 52 studies were included, representing 861 (86% PKU) receiving after IMD diagnosis (mean duration 4–10 months depending on IMD). For non‐PKU IMDs (e.g., other amino acidopathies, urea cycle disorders, organic acidemias, fatty acid oxidation disorders), outcomes available few infants, except medium‐chain acyl‐CoA dehydrogenase (MCAD) deficiency ( n = 48). PKU, combined phenylalanine‐free formula, led adequate control (25 studies), growth (15 neurodevelopment (10 studies). IMDs, more evidence required, but limited data suggest that possible, attentive monitoring disease‐specific formula supplementation where applicable. MCAD deficiency, ensuring intake essential, as symptoms frequently reported exclusively breastfed No IMD‐specific articles found relationship between many interest immune status or comorbidity risk later life). With exception benefit IMD. More should published than PKU.

Language: Английский

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The Legacy of COVID-19 in Breast Milk: The Association of Elevated Anti-Inflammatory and Antimicrobial Proteins with Vaccination or Infection

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(3), P. 182 - 182

Published: March 11, 2025

Background: Breast milk is a rich source of antimicrobial and anti-inflammatory compounds, owing to its diverse array bioactive molecules. This study explores the presence activity natural agents in breast milk, particularly context SARS-CoV-2 pandemic. Materials Methods: samples were collected from 50 breastfeeding mothers, including those who had either been vaccinated against or recovered infection. These compared with control group consisting 10 unvaccinated mothers no history COVID-19. Key immune-regulatory proteins—lactoferrin, lactadherin, furin, tenascin C, granzyme B, chitinase 3-like 1—were quantified using Luminex multiplex analyzer. Results Discussion: All targeted biomarkers detected providing insights into immune profile transferred infants following COVID-19 infection vaccination. molecules highlight breastfeeding’s role passive immunity protection. The protein levels found be influenced by factors such as maternal inflammation, infant age, delivery mode, parity, emphasizing dynamic interaction between immunity, lactation biology, development. Conclusion: Breastfeeding serves powerful anti-SARS-CoV-2 defense mechanism, supported lactoferrin, reinforcing critical child health.

Language: Английский

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Consecutive Lactation, Infant Birth Weight and Sex Do Not Associate with Milk Production and Infant Milk Intake in Breastfeeding Women

Nutrients, Journal Year: 2025, Volume and Issue: 17(6), P. 1062 - 1062

Published: March 18, 2025

Background/Objectives: Optimal infant growth is reliant on the sufficient intake of human milk. Studies in animal models speculate that multiparous mothers produce a higher milk yield compared to primiparous mothers. We aimed examine if there are relationships between consecutive lactations and demographics both maternal 24 h production (MP) (MI). Methods: Lactating 1–6 months postpartum (n = 36; 25 fully breastfeeding (FBF), 11 supplementing with commercial formula (partly (PBF)) test-weighed their infants for during two provided demographic information. Twenty-four-hour MP by breast, MI (including mothers’ own expressed formula), expressing frequencies were measured. The statistical analysis used linear mixed modelling accounting birth weight (FBF) or time (PBF) random effect participant. Results: In FBF group, no differences terms (p 0.31) mother’s 0.14). was lactation 0.008). Infant sex not associated 0.12) 0.090). PBF frequency 0.042), 0.025) 0.019) whilst lower 0.004). Conclusions: This study suggests women, significant established lactation.

Language: Английский

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Breast milk Na+ and Na+/K+ ratio predict delayed onset of lactogenesis in gestational hyperglycemia

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 9, 2025

To investigate the predictive value of breast milk Na+ concentration and Na+/K+ ratio on delayed onset lactogenesis (DOL) in puerpera with gestational hyperglycemia. Puerpera hyperglycemia who delivered at The First Affiliated Hospital Army Medical University China between October 20, 2023, April 1, 2024, were enrolled. concentrations K+ samples examined from study participants days 1-3 postpartum period. DOL assessed using receiver operating characteristic (ROC) curves. Both collected day 3 could effectively predict DOL, areas under curve (AUCs) ROC 95%CI values 94.7% (95%CI = 0.901-0.992) 94.2% 0.890-0.994), respectively. optimized cutoffs ≥ 26.25 mmol/L (sensitivity 88.2%, specificity 92.2.8%) 1.646 79.4%, 98.4%). Na⁺ found to be effective predicting

Language: Английский

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Breastfeeding Counseling Practices Among Plastic Surgeons: Results From a National Survey

Plastic & Reconstructive Surgery Global Open, Journal Year: 2025, Volume and Issue: 13(4), P. e6691 - e6691

Published: April 1, 2025

Background: Breastfeeding has well-established benefits for maternal and infant health. Difficulty with breastfeeding is a possible complication after breast surgery can have detrimental psychological consequences. Although lactation outcomes been reported, plastic surgeons’ preoperative counseling practices regarding not yet studied. Methods: From November 2021 to January 2022, 25-question anonymous survey on practices, personal experiences, demographics, surgical training, length of practice was administered 6000 members the American Society Plastic Surgeons. Results: A total 146 respondents were included, 90.7% believe that affect breastfeeding. 96.6% routinely discuss postoperative challenges breastfeeding, 39.3% differentiate between inclusive exclusive 22.2% potential emotional consequences, only 12.8% need galactagogues or labor-intensive ancillary activities. Significantly more who had in less than 15 years believed reported impairment risk before transgender top surgery, compared those out training (96% versus 84%, P = 0.05; 72% 54%, 0.05). Conclusions: Most surgeons counsel patients as such. However, deleterious mental health consequences challenged seem undercounseled. Our findings highlight increased education improved protocols surgeons.

Language: Английский

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Let Me Stay With Mom! – Safely Doing Less for 35-Week Infants

Hospital Pediatrics, Journal Year: 2025, Volume and Issue: unknown

Published: April 25, 2025

Language: Английский

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European guidelines on diagnosis and treatment of phenylketonuria: First revision

Molecular Genetics and Metabolism, Journal Year: 2025, Volume and Issue: unknown, P. 109125 - 109125

Published: April 1, 2025

Language: Английский

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Re-thinking benign inflammation of the lactating breast: Classification, prevention, and management

Women s Health, Journal Year: 2022, Volume and Issue: 18

Published: Jan. 1, 2022

Despite the known benefits of breastfeeding for both infant and mother, clinical support problems such as benign inflammation lactating breast remain a research frontier. Breast pain associated with is common reason premature weaning. Multiple diagnoses are used inflammatory conditions which lack agreed or evidence-based aetiology, definitions, treatment. This article second in three-part series. review analyses heterogeneous literature concerning lactation-related from perspectives mechanobiological model complexity science, to re-think classification, prevention, management inflammation. Benign spectrum condition, either localized generalized. Acute includes engorgement commonly but poorly defined blocked ducts, phlegmon, mammary candidiasis, subacute mastitis, mastitis. End-stage (non-malignant) presents active inflammations abscess, fistula, septicaemia, inactive condition galactocoele. The first preventive principle avoidance excessively high intra-alveolar intra-ductal pressures, prevents strain rupture critical mass lactocyte tight junctions. achieved by frequent flexible milk removal. elimination mechanical forces result pressures. requires conflicting vectors force upon nipple tissue during removal; focussed external pressure applied breast, including lump massage vibration; other prolonged pressures breast. Three key principles discussed. Conservative expected be effective most, once recommendations vibrate out lumps, worsen micro-vascular trauma inflammation, ceased.

Language: Английский

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Sampling Procedures for Estimating the Infant Intake of Human Milk Leptin, Adiponectin, Insulin, Glucose, and Total Lipid

Nutrients, Journal Year: 2024, Volume and Issue: 16(3), P. 331 - 331

Published: Jan. 23, 2024

Limited attention is given to the efficacy of protocols for estimation infant intake milk components when investigating their impact on outcomes. We compared actual measured human with estimations derived from 15 determine most reliable approach estimating HM leptin, adiponectin, insulin, glucose, and total lipid. Twenty mothers who were 3–5 months postpartum completed a 24 h profile study pre-/post-feed samples collection. The true (control group) based (MI) was estimated intakes using concentrations five sampling that multiplied by one MI, considered mean MI (800 mL), or global (766 mL). six (three sets pre- post-feed samples, morning (06:00–09:00), afternoon (13:00–16:00), evening (19:00–22:00)) produced accurate estimates these components. Therefore, in absence measurements sampling, protocol comprising three provides

Language: Английский

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The Role of Skin-to-Skin Contact and Breastfeeding in the First Hour Post Delivery in Reducing Excessive Weight Loss

Children, Journal Year: 2024, Volume and Issue: 11(2), P. 232 - 232

Published: Feb. 10, 2024

Background and aims: An excessive weight loss (EWL) of >10% after birth is associated with serious health outcomes. The aim this study was to determine factors that can reduce in full-term, exclusively breastfed infants birth. Methods: This a retrospective, observational, single-center study. We included 642 healthy, neonates born 2019 baby-friendly hospital, their healthy mothers. exclusion criteria were as follows: supplementation formula, multiple pregnancies, or mothers issues. Results: mean percentage neonatal 24 h life 5.13%, 48 6.34%. Neonates delivered via caesarean section lost more than those vaginal delivery (p < 0.01). There noticeable pattern tend lose if they do not get skin-to-skin contact (SSC) breastfeeding within the first hour > 0.05). Conclusions: CS life. Immediate SSC may decrease loss.

Language: Английский

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