Effect of the 5:2 Diet on Weight Loss and Cardiovascular Disease Risk Factors in Overweight and/or Obesity: A Systematic Review and Meta‐Analysis

International Journal of Endocrinology, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

Introduction: We conducted a systematic review and meta-analysis to evaluate the effects of 5:2 diet on weight loss cardiovascular disease (CVD) risk factors in overweight obese individuals. Methods: Databases (PubMed, The Cochrane Library, Web Science, Embase) were searched for randomized controlled trials intervention search period was from database establishment April 2024. RevMan 5.3 Stata 14.0 used meta-analysis. Results: A total 20 articles with 1393 participants finally included. There 689 treatment groups 704 control groups. showed that significantly reduces body weight, mass index, waist circumference, fat percentage, hip mass, fat-free low-density lipoprotein, systolic blood pressure, homeostasis model assessment-insulin resistance levels relative group (p < 0.05). However, there no significant difference visceral fat, cholesterol, triglycerides, high-density diastolic insulin, fasting glucose, glycated hemoglobin A1c, heart rate. Although serious adverse events group, this experienced mild physical psychological side during period, which resolved spontaneously after fasting. Conclusion: is effective reduction amelioration CVD overweight/obesity safe feasible. patient's condition should be monitored timely adjustments made accordingly.

Language: Английский

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Impact of Intermittent Fasting on Serum Cardiac Biomarkers in Male Wistar Rats

International Journal of Clinical and Experimental Medical Sciences, Journal Year: 2025, Volume and Issue: 11(1), P. 11 - 17

Published: April 22, 2025

&lt;i&gt;Background&lt;/i&gt;: Intermittent fasting (IF) is a widely adopted strategy for weight loss; however, it has also been linked to potential risks, including an increased likelihood of cardiovascular complications. This study aimed investigate the effects intermittent on cardiac biomarkers in male Wistar rat models. &lt;i&gt;Methods&lt;/i&gt;: Twenty (20) rats (130 g) were used study. They randomly assigned four (4), consisting five (5) per group. Group I served as control while groups II, III, and IV experimental intermittently fasted 6 hours, 8 12 respectively, (4) weeks. Blood samples collected determine serum biomarkers: troponin-I (cTnI), troponin-T (cTnT), aspartate transaminase (AST). &lt;i&gt;Results&lt;/i&gt;: There was significant increase cTnI, cTnT, AST levels among 12-hour group (IV) compared (I), 6-hour IF (II) 8-hour (III) (p&lt;0.05). Similarly, mean significantly elevated Expectedly, there reduction body all (p&lt;0.01). &lt;i&gt;Conclusion&lt;/i&gt;: Prolonged could pose risk health, necessitating careful consideration monitoring regime.

Language: Английский

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Ketogenic diet and β-hydroxybutyrate inhibit HDAC1 to preserve vascular smooth muscle cell function in thoracic aortic aneurysm

Journal of Advanced Research, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Thoracic aortic aneurysm (TAA) is a serious condition characterized by dilation of the thoracic aorta, often leading to dissection or rupture. Current treatments involve surgical and pharmacological interventions do not effectively address underlying molecular mechanisms. This study explores effects ketogenic diet (KD) on TAA, focusing histone deacetylase 1 (HDAC1) vascular smooth muscle cells (VSMCs) function. A β-aminopropionitrile monofumarate (BAPN)-induced TAA mouse model was used. Mice were divided into groups receiving either standard KD. Additionally, β-hydroxybutyrate (BHB), KD-derived ketone body, parthenolide ITSA-1 administered. The measured survival rates, dilation, elastin degradation, VSMC contractile markers, mitochondrial function, oxidative stress levels. KD significantly improved rates reduced degradation in model. BHB also mitigated development, demonstrating similar protective effects. particularly effective preserving function maintaining phenotype restoring marker expression. addition HDAC1 inhibitor HDAC agonist further evaluated against damage. Our reveals important roles regulating HDAC1, phenotype, reducing TAA. findings demonstrate as promising therapeutic strategies for treating targeting specific pathways involved its progression. highlights significance innovation lifestyle interventions, such KD, mitigating addressing

Language: Английский

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High protein intake causes gene-length-dependent transcriptional decline, shortens lifespan and accelerates ageing in progeroid DNA repair-deficient mice

npj Metabolic Health and Disease, Journal Year: 2025, Volume and Issue: 3(1)

Published: May 22, 2025

Language: Английский

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Scientific Evidences of Calorie Restriction and Intermittent Fasting for Neuroprotection in Traumatic Brain Injury Animal Models: A Review of the Literature

Nutrients, Journal Year: 2022, Volume and Issue: 14(7), P. 1431 - 1431

Published: March 30, 2022

It has widely been accepted that food restriction (FR) without malnutrition multiple health benefits. Various calorie (CR) and intermittent fasting (IF) regimens have recently reported to exert neuroprotective effects in traumatic brain injury (TBI) through variable mechanisms. However, the evidence connecting CR or IF neuroprotection TBI as well current issues remaining this research field yet be reviewed literature. The objective of our review was therefore weigh suggests connection between CR/IF with recovery promotion following TBI. Medline, Google Scholar Web Science were searched from inception 25 February 2022. An overwhelming number results generated suggest several types play a promising role promoting post-TBI recovery. This is believed achieved by alleviating mitochondrial dysfunction, hippocampal neurogenesis, inhibiting glial cell responses, shaping neural plasticity, targeting apoptosis autophagy. Further, we represent views on provide thoughts future direction field.

Language: Английский

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