Effects of β‐hydroxy β‐methylbutyrate (HMB) supplementation on muscle mass, function, and other outcomes in patients with cancer: a systematic review

Journal of Cachexia Sarcopenia and Muscle, Journal Year: 2022, Volume and Issue: 13(3), P. 1623 - 1641

Published: March 17, 2022

Language: Английский

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Phase Angle, Handgrip Strength, and Other Indicators of Nutritional Status in Cancer Patients Undergoing Different Nutritional Strategies: A Systematic Review and Meta-Analysis

Nutrients, Journal Year: 2023, Volume and Issue: 15(7), P. 1790 - 1790

Published: April 6, 2023

Malnutrition in cancer patients is one of the most influential factors evolution and mortality such patients. To reduce incidence malnutrition, it necessary to establish a correct nutritional intervention. For this purpose, precise tools indicators must be developed determine patient’s condition. The main objective systematic review meta-analysis was analyze relationship between different strategies, phase angle (PA), handgrip strength with cancer, secondary objectives being modification other status, as weight body mass index (BMI). A randomized clinical trials carried out March 2023 databases PubMed, Web Science, Cochrane, Scopus. As risk-of-bias tool, RoB 2.0 utilized. total 8 studies 606 participants were included analysis. significant increase PA observed after strategies (SMD: 0.43; 95% CI: 0.10 0.77; p = 0.01; I2 65.63%), also detecting 0.27, 0.08 0.47; 30.70%). subjected strategies. These results suggest that these could used functional assessment

Language: Английский

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The effects of β-hydroxy-β-methylbutyrate or HMB-rich nutritional supplements on sarcopenia patients: a systematic review and meta-analysis

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11

Published: July 12, 2024

Background Sarcopenia is a progressive, systemic skeletal muscle disorder. Resistance exercise and physical activity have been proven effective in its treatment, but consensus on pharmacological interventions has not yet reached clinical practice. β-Hydroxy-β-methylbutyrate (HMB) nutritional supplement that demonstrated favorable effects protein turnover, potentially contributing to beneficial impacts sarcopenia. Aim To assess the potential positive of HMB or HMB-containing supplements individuals with sarcopenia, systematic review meta-analysis was conducted. Methods A were conducted randomized controlled trials (RCTs) examining treatment sarcopenia HMB. Two assessors independently screening, data extraction, bias risk assessment. Outcome synthesized through random-effects model meta-analysis, using mean difference (MD) as effect measure. Results six studies. HMB-rich showed statistically significant Hand Grip Strength (HGS) for patients [MD = 1.26, 95%CI (0.41, 2.21), p 0.004], while there no Gait Speed (GS) 0.04, (−0.01, 0.08), 0.09], Fat Mass (FM) −0.18, (−0.38, 0.01), 0.07], Fat-Free (FFM) 0.09, (−0.23, 0.42), 0.58], Skeletal Muscle Index (SMI) 0.01, (−0.00, 0.13]. Conclusion are strength patients. However, limited evidence demonstrating both performance individuals. may be considered option Systematic registration CRD42024512119.

Language: Английский

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Effects of Oral Nutritional Supplement with β-Hydroxy-β-methylbutyrate (HMB) on Biochemical and Hematological Indices in Community-Dwelling Older Adults at Risk of Malnutrition: Findings from the SHIELD Study

Nutrients, Journal Year: 2024, Volume and Issue: 16(15), P. 2495 - 2495

Published: July 31, 2024

Malnutrition may result in abnormal biochemical and hematological indices. This planned prespecified analysis investigated the effects of a specialized oral nutritional supplement (ONS) on indices community-dwelling older adults at risk malnutrition. In Strengthening Health ELDerly through nutrition (SHIELD) study, 811 aged 65 years above took part this randomized, double-blind, placebo-controlled, multi-center study. Participants were randomly allocated to either complete balanced ONS (each serving provides 262 kcal, 10.5 g protein, 7.75 µg vitamin D3, 0.74 calcium β-hydroxy-β-methylbutyrate) dietary counselling (intervention group) or placebo (placebo group). Both groups consumed study products twice day for 180 days. Data collected baseline, 90, 180. Blood results follow-up visits analyzed using repeated measures covariance with adjustments confounders. Overall, when compared group, intervention group showed significantly greater urea (6.0 mmol/L vs. 5.4 mmol/L, p < 0.001), creatinine ratio (4.39 4.26, prealbumin (24.9 mg/dL 24.0 mg/dL, B12 (480.0 pmol/L 420.1 pmol/L, globulin levels (26.8 g/L 26.5 g/L, = 0.032). The also had higher absolute reticulocyte count (62.0 × 103/µL 58.2 103/µL, overall 0.001) mean platelet volume (10.0 fL 9.9 fL, 0.003). Furthermore, significant improvements seen total protein 90 (71.7 71.1 0.017) monocyte (0.50 0.47 0.009) group. conclusion, daily consumption six months led

Language: Английский

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Understanding the complexity of barriers and facilitators to adherence to oral nutritional supplements among patients with malnutrition: a systematic mixed-studies review

Nutrition Research Reviews, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 21

Published: Oct. 9, 2024

The aim of this systematic mixed-studies review is to summarise barriers/facilitators adherence and/or consumption oral nutritional supplements (ONS) among patients with disease-related malnutrition. In March 2022, the Cochrane CENTRAL, PUBMED, PsycINFO (Ovid) and CINAHL were searched for articles various study designs, published since 2000. Articles identified on basis 'population' (patients ≥18 years malnutrition/at risk), 'intervention' (ONS ≥2 macronutrients micronutrients), 'comparison' (any comparator/no comparator) 'outcome' (factors affecting or consumption) criteria. A sequential exploratory synthesis was conducted: first, a thematic performed identifying barriers/facilitators; second, randomised controlled trials (RCTs) used support these findings. five WHO dimensions guided analysis. Study inclusion, data extraction, analysis risk-of-bias assessment (MMAT 2018) carried out independently by two researchers. From 21 835 screened articles, 171 included 42% RCTs 20% qualitative studies. major populations malignancies (34%) older adults (35%). total, fifty-nine identified. Patients' health status, motivation, product tolerance satisfaction as well well-functioning healthcare routines factors impacting ONS consumption. Few (

Language: Английский

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Adherence to Oral Nutritional Supplements: A Review of Trends in Intervention Characteristics and Terminology Use Since the Year 2000

Food Science & Nutrition, Journal Year: 2025, Volume and Issue: 13(1)

Published: Jan. 1, 2025

ABSTRACT Research on disease‐related malnutrition and adherence to oral nutritional supplements (ONS) has increased in recent years. To guide future studies, it is important identify trends terminology use intervention characteristics. This review aimed map characteristics of research investigating ONS patients with explore changes over time. a secondary analysis quantitative studies from systematic mixed‐studies review. Online databases, including PubMed, Cinahl, Cochrane Central Register Controlled Trials, APA PsycInfo, were searched published 2000 March 2022. A content extracted data was performed, the Mixed Methods Appraisal Tool (MMAT) used assess methodological risk bias. includes 137 articles, half which are randomized controlled trials (52%). The term “oral supplements” 40% studies. Adherence mainly described by “compliance” (69%). It most common offer ready‐made milk‐based (56%) as sole (51%). prescribed dose fixed 64% individualized 22% There variation methods ONS, not reported nearly fifth an increase quality time ( p = 0.024). ensure better understanding rigor reproducibility research, crucial standardize describe interventions clearly.

Language: Английский

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Adherence to β-hydroxy-β-methylbutyrate-Enriched Oral Nutritional Supplements Enhances Survival and Nutritional Recovery in Malnourished Outpatients: Prognostic Insights

Nutrients, Journal Year: 2025, Volume and Issue: 17(9), P. 1601 - 1601

Published: May 7, 2025

Background: Disease-related malnutrition (DRM) in outpatients is associated with increased mortality and functional decline. Morphofunctional assessments, including phase angle (PA), rectus femoris cross-sectional area (RF-CSA), handgrip strength (HGS), provide valuable prognostic insights the ambulatory setting. Nutritional recovery programs enriched β-hydroxy-β-methylbutyrate (HMB) offer potential benefits improving nutritional outcomes. Objective: To evaluate effects of a six-month program combining HMB-enriched oral supplements (HMB-ONS), dietary recommendations, exercise on survival, morphofunctional markers, adherence malnourished outpatients. Methods: This retrospective observational study included 135 diagnosed using GLIM criteria. assessments PA (bioimpedance analysis), RF-CSA (nutritional ultrasound), HGS (dynamometry), Timed Up Go (TUG) test. Adherence was assessed pharmacy retrieval records validated questionnaire. Changes markers their association were analyzed multivariate Cox regression models. Results: After six months, significant improvements observed (+0.47°), (+0.90 cm2), (+4.1 kg), TUG (−0.93 s) (all p < 0.001). These more pronounced high-adherence group, which also exhibited reduced risk (HR 0.42, 0.05). strongly ΔPA showing an HR 0.27 (95% CI: 0.15–0.50, 0.001) ΔHGS 0.82 0.75–0.89, Conclusions: A HMB-ONS significantly improves survival patients, greatest those high adherence. findings underscore importance adherence-support strategies optimizing clinical outcomes highlight need for further research to confirm long-term benefits.

Language: Английский

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Biomarker Changes in Response to a 12-Week Supplementation of an Oral Nutritional Supplement Enriched with Protein, Vitamin D and HMB in Malnourished Community Dwelling Older Adults with Sarcopenia

Nutrients, Journal Year: 2022, Volume and Issue: 14(6), P. 1196 - 1196

Published: March 11, 2022

Malnutrition and sarcopenia commonly overlap contribute to adverse health outcomes. Previously, chronic supplementation with two oral nutritional supplements (ONS), control (CONS) experimental ONS enriched protein, vitamin D β-hydroxy β-methylbutyrate (HMB) (EONS), improved muscle strength quality in malnourished sarcopenic older adults, EONS demonstrating early benefits at 12 weeks. To understand the underlying biological mechanisms contributing observed of EONS, we examined serum biomarker changes response 12-week supplementation. Serum samples (EONS (n = 90) CONS 103)) collected baseline weeks were analyzed. Biomarkers 243) measured using multiplexed immunoassay, commercial immunoassays ELISAs. Sixty markers excluded levels below assay detection limits. Sixteen biomarkers significantly changed both interventions including metabolic markers. Thirteen but not CONS. Increases immunoglobulins, myoglobin, total E magnesium EONS. Inflammation-related ferritin osteopontin decreased, while soluble receptors for cytokines increased, suggesting decreased inflammation. Sex hormone-binding globulin associated also reflective multiple systems impacted by intervention adults. Incremental containing HMB that possibly link improvements skeletal health.

Language: Английский

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Randomized Clinical Trial: Effects of β-Hydroxy-β-Methylbutyrate (HMB)-Enriched vs. HMB-Free Oral Nutritional Supplementation in Malnourished Cirrhotic Patients

Nutrients, Journal Year: 2022, Volume and Issue: 14(11), P. 2344 - 2344

Published: June 3, 2022

β-Hydroxy-β-methylbutyrate (HMB) supplementation increases muscle and strength mass in some muscle-wasting disorders. Malnutrition sarcopenia are often present liver cirrhosis. We aimed to investigate the effects of oral HMB on changes body composition status patients with cirrhosis malnutrition. In a randomized, controlled, double-blind trial, 43 individuals were randomized receive twice day for 12 weeks an nutritional supplement (ONS) enriched 1.5 g calcium per bottle or another similar devoid HMB. Inclusion criteria at least one previous decompensation clinical Liver function, plasma biochemistry analyses, physical condition assessment carried out baseline, then after six supplementation. A total 34 completed trial. An improvement function increase fat index observed both groups. None two ONS changed fat-free mass. However, we upward trend handgrip downward minimal hepatic encephalopathy group. At end trial regardless administered, content increased no change mass, while scores analytic markers also improved.

Language: Английский

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Effectiveness of High-Protein Energy-Dense Oral Supplements on Patients with Malnutrition Using Morphofunctional Assessment with AI-Assisted Muscle Ultrasonography: A Real-World One-Arm Study

Nutrients, Journal Year: 2024, Volume and Issue: 16(18), P. 3136 - 3136

Published: Sept. 17, 2024

Background: User-friendly tools for assessing nutrition status and interventions in malnourished patients are crucial. This study evaluated the effectiveness of a personalised intervention using novel oral nutritional supplement AI-supported morphofunctional assessment to monitor clinical outcomes with disease-related malnutrition (DRM). Methods: prospective observational involved receiving concentrated high-protein, high-calorie ONS (cHPHC-ONS), per usual practice. Comprehensive assessments were performed at baseline (B0) three months (M3) post-intervention. Results: 65 participated study. Significant decreases observed percentage weight loss from B0 (−6.75 ± 7.5%) M3 (0.5 3.48%) (p < 0.01), prevalence (B0: 93.4%; M3: 78.9%; p severe 60.7%; 40.3%; sarcopenia 19.4%; 15.5%; 0.04). Muscle area increased = 0.03), there changes echogenicity rectus femoris muscle 0.03) M3. In aged ≥60, an increase thickness 0.04), pennation angle 0.02), handgrip strength 0.04) was observed. There significant reduction 0.01) 0.01). Conclusions: DRM, cHPHC-ONS significantly reduces malnutrition, improves mass function.

Language: Английский

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