Nutrients,
Journal Year:
2024,
Volume and Issue:
16(5), P. 590 - 590
Published: Feb. 21, 2024
Amyotrophic
Lateral
Sclerosis
(ALS)
is
a
highly
fatal
neurodegenerative
disorder
characterized
by
the
progressive
wasting
and
paralysis
of
voluntary
muscle.
Despite
extensive
research,
etiology
ALS
remains
elusive,
effective
treatment
options
are
limited.
However,
recent
evidence
implicates
gut
dysbiosis
gut-brain
axis
(GBA)
dysfunction
in
pathogenesis.
Alterations
to
composition
diversity
microbial
communities
within
flora
have
been
consistently
observed
patients.
These
changes
often
correlated
with
disease
progression
patient
outcome,
suggesting
that
GBA
modulation
may
therapeutic
potential.
Indeed,
targeting
microbiota
has
shown
be
neuroprotective
several
animal
models,
alleviating
motor
symptoms
mitigating
progression.
translation
these
findings
human
patients
challenging
due
complexity
pathology
varying
microbiota.
This
review
comprehensively
summarizes
current
literature
on
ALS-related
dysbiosis,
focusing
implications
dysfunction.
It
delineates
three
main
mechanisms
which
contributes
pathology:
compromised
intestinal
barrier
integrity,
metabolic
dysfunction,
immune
dysregulation.
also
examines
preclinical
potential
gut-microbiota-modulating
agents
(categorized
as
prebiotics,
probiotics,
postbiotics)
ALS.
Nutrients,
Journal Year:
2022,
Volume and Issue:
14(12), P. 2543 - 2543
Published: June 19, 2022
Probiotics
improve
brain
function,
including
memory
and
cognition,
via
the
microbiome-gut-brain
axis.
Oral
administration
of
Bifidobacterium
breve
MCC1274
(B.
MCC1274)
improves
cognitive
function
in
AppNL-G-F
mice
mild
impairment
(MCI)
subjects,
mitigates
Alzheimer's
disease
(AD)-like
pathologies.
However,
its
effects
on
wild-type
(WT)
have
not
yet
been
explored.
Thus,
B.
AD-like
pathologies
two-month-old
WT
were
investigated,
which
orally
administered
for
four
months.
Aβ
levels,
amyloid
precursor
protein
(APP),
APP
processing
enzymes,
phosphorylated
tau,
synaptic
glial
activity,
cell
proliferation
subgranular
zone
dentate
gyrus
evaluated.
Data
analysis
was
performed
using
Student's
t-test,
normality
tested
Shapiro-Wilk
test.
decreased
soluble
hippocampal
Aβ42
levels
by
reducing
presenilin1
reduced
tau
levels.
It
also
activated
kinase
B
(Akt)/glycogen
synthase
kinase-3β
(GSK-3β)
pathway,
may
be
responsible
reduction
inhibition
phosphorylation.
supplementation
attenuated
microglial
activation
elevated
hippocampus.
These
findings
suggest
that
mitigate
decreasing
inhibiting
phosphorylation,
attenuating
neuroinflammation,
improving
Frontiers in Cellular and Infection Microbiology,
Journal Year:
2023,
Volume and Issue:
13
Published: Oct. 4, 2023
The
microbiota
gut
brain
(MGB)
axis
has
been
shown
to
play
a
significant
role
in
the
regulation
of
inflammatory
and
infective
diseases.
Exploring
structure
communication
mode
MGB
is
crucial
for
understanding
its
diseases,
studying
signaling
pathways
regulatory
methods
diseases
also
profound
significance
future
clinical
research.
This
article
reviews
composition,
mechanism
including
Parkinson’s
disease
(PD),
Alzheimer’s
(AD),
multiple
sclerosis
(MS),
autism
spectrum
disorder
(ASD),
depression,
psoriasis,
irritable
bowel
syndrome
(IBS),
(IBD).
In
addition,
our
investigation
delved
into
functions
inflammasome,
IFN-I,
NF-κB,
PARK7/DJ-1
innate
immune
pathway
context
Ultimately,
we
discussed
efficacy
various
interventions,
fecal
transplantation
(FMT),
antibiotics,
probiotics,
prebiotics,
synbiotics,
postbiotics,
management
Understanding
might
make
positive
effects
treatment
Processes,
Journal Year:
2024,
Volume and Issue:
12(2), P. 316 - 316
Published: Feb. 2, 2024
Probiotics,
living
microorganisms
with
demonstrated
health
benefits
when
administered
in
sufficient
quantities,
have
a
rich
history
as
dietary
supplements
to
benefit
human
health.
Recently,
understanding
of
their
mechanisms
the
gastrointestinal
tract
has
prompted
exploration
probiotics
treating
diseases.
However,
effective
and
precise
delivery
remains
significant
challenge
therapeutic
applications.
Here,
we
review
action
most
advanced
strategies
for
efficient
probiotic
delivery.
We
also
discuss
potential
applications
engineered
disease
treatment.
This
contributes
insights
into
evolving
landscape
research
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(5), P. 590 - 590
Published: Feb. 21, 2024
Amyotrophic
Lateral
Sclerosis
(ALS)
is
a
highly
fatal
neurodegenerative
disorder
characterized
by
the
progressive
wasting
and
paralysis
of
voluntary
muscle.
Despite
extensive
research,
etiology
ALS
remains
elusive,
effective
treatment
options
are
limited.
However,
recent
evidence
implicates
gut
dysbiosis
gut-brain
axis
(GBA)
dysfunction
in
pathogenesis.
Alterations
to
composition
diversity
microbial
communities
within
flora
have
been
consistently
observed
patients.
These
changes
often
correlated
with
disease
progression
patient
outcome,
suggesting
that
GBA
modulation
may
therapeutic
potential.
Indeed,
targeting
microbiota
has
shown
be
neuroprotective
several
animal
models,
alleviating
motor
symptoms
mitigating
progression.
translation
these
findings
human
patients
challenging
due
complexity
pathology
varying
microbiota.
This
review
comprehensively
summarizes
current
literature
on
ALS-related
dysbiosis,
focusing
implications
dysfunction.
It
delineates
three
main
mechanisms
which
contributes
pathology:
compromised
intestinal
barrier
integrity,
metabolic
dysfunction,
immune
dysregulation.
also
examines
preclinical
potential
gut-microbiota-modulating
agents
(categorized
as
prebiotics,
probiotics,
postbiotics)
ALS.
