Protective effects of curcumin against traumatic brain injury

Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 154, P. 113621 - 113621

Published: Aug. 29, 2022

Neuroinflammation is a key pathophysiological mechanism implicated in the neurodegenerative condition. One such condition implicating neuroinflammation traumatic brain injury (TBI). Over past decades, various alternative natural compounds, as curcumin, have been investigated novel therapeutic options to mitigate pathways and clinical sequelae involved TBI. As main component of turmeric (Curcuma longa), curcumin has broad range properties due its considerable antioxidative anti-inflammatory actions. This review discusses pleiotropic mechanisms, side effects, curcumin's delivery central nervous system (CNS), immunomodulatory protective effects on Clinical trials, vivo, vitro studies were extracted from different scientific databases, including PubMed, Scopus, Google Scholar, assess or derivatives Findings reveal that exhibited some TBI via modulation cell signaling toll-like receptor-4 (TLR-4), nuclear factor kappa B (NF-κB), Nod-like receptor family proteins (NLRPs). Moreover, upregulates brain-derived Neurotrophic Factor/Tropomyosin kinase (BDNF/TrkB) pathway, phosphatidylinositol-3-kinase/protein (PI3K/AKT), erythroid 2-related 2 (Nrf2), which crucial functions pathophysiological-mediated pathways. Curcumin displays beneficial capacities models, although more experiments are required clarify precise mechanisms function

Language: Английский

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Curcumin‐piperine co‐supplementation and human health: A comprehensive review of preclinical and clinical studies

Phytotherapy Research, Journal Year: 2023, Volume and Issue: 37(4), P. 1462 - 1487

Published: Jan. 31, 2023

Abstract Curcumin is extracted from the rhizomes Curcuma longa L. It known for its anti‐inflammatory and anti‐oxidant activities. Despite safety potential use against various diseases, curcumin's utility restricted due to low oral bioavailability. Co‐administration of curcumin along with piperine could potentially improve bioavailability curcumin. The present review aimed provide an overview efficacy curcumin‐piperine co‐supplementation in human health. findings this comprehensive show beneficial effects improving glycemic indices, lipid profile antioxidant status diabetes, inflammatory caused by obesity metabolic syndrome, reducing oxidative stress depression chronic neurological disorders, also respiratory asthma COVID‐19. Further high‐quality clinical trial studies are needed firmly establish supplement.

Language: Английский

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Curcumin and chemokines: mechanism of action and therapeutic potential in inflammatory diseases

Inflammopharmacology, Journal Year: 2023, Volume and Issue: 31(3), P. 1069 - 1093

Published: March 30, 2023

Language: Английский

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The potential role of ischaemia–reperfusion injury in chronic, relapsing diseases such as rheumatoid arthritis, Long COVID, and ME/CFS: evidence, mechanisms, and therapeutic implications

Biochemical Journal, Journal Year: 2022, Volume and Issue: 479(16), P. 1653 - 1708

Published: Aug. 31, 2022

Ischaemia-reperfusion (I-R) injury, initiated via bursts of reactive oxygen species produced during the reoxygenation phase following hypoxia, is well known in a variety acute circumstances. We argue here that I-R injury also underpins elements pathology chronic, inflammatory diseases, including rheumatoid arthritis, ME/CFS and, our chief focus and most proximally, Long COVID. Ischaemia may be fibrin amyloid microclot blockage capillaries, for instance as exercise started; reperfusion necessary corollary when it finishes. rehearse mechanistic evidence these occurrences here, terms their manifestation oxidative stress, hyperinflammation, mast cell activation, production marker metabolites related activities. Such microclot-based phenomena can explain both breathlessness/fatigue post-exertional malaise observed conditions, many other observables. The recognition processes implies, mechanistically, therapeutic benefit potentially to had from antioxidants, anti-inflammatories, iron chelators, suitable, safe fibrinolytics, and/or anti-clotting agents. review considerable existing consistent with this, biochemical mechanisms involved.

Language: Английский

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COVID-19 at a Glance: An Up-to-Date Overview on Variants, Drug Design and Therapies

Viruses, Journal Year: 2022, Volume and Issue: 14(3), P. 573 - 573

Published: March 10, 2022

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a member of the Coronavirus family which caused worldwide pandemic human illness coronavirus disease 2019 (COVID-19). Presumably emerging at end 2019, it poses severe threat to public health and safety, with high incidence transmission, predominately through aerosols and/or direct contact infected surfaces. In 2020, search for vaccines began, leading obtaining of, date, about twenty COVID-19 approved use in least one country. However, continues spread new genetic mutations variants have been discovered, requiring pharmacological treatments. The most common therapies are represented by antiviral antimalarial agents, antibiotics, immunomodulators, angiotensin II receptor blockers, bradykinin B2 antagonists corticosteroids. addition, nutraceuticals, vitamins D C, omega-3 fatty acids probiotics under study. Finally, drug repositioning, concerns investigation existing drugs therapeutic target indications, has widely proposed literature therapies. Considering importance this ongoing global emergency, review aims offer synthetic up-to-date overview regarding diagnoses, COVID-19, particular attention paid adopted

Language: Английский

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The efficacy of curcumin-piperine co-supplementation on clinical symptoms, duration, severity, and inflammatory factors in COVID-19 outpatients: a randomized double-blind, placebo-controlled trial

Trials, Journal Year: 2022, Volume and Issue: 23(1)

Published: June 6, 2022

Abstract Background COVID-19 pandemic has made the disease a major global problem by creating significant burden on health, economic, and social status. To date, there are no effective approved medications for this disease. Curcumin as an anti-inflammatory agent can have positive effect control of complications. This study aimed to assess efficacy curcumin-piperine supplementation clinical symptoms, duration, severity, inflammatory factors in patients with COVID-19. Methods Forty-six outpatients were randomly allocated receive two capsules curcumin-piperine; each capsule contained 500 mg curcumin plus 5 piperine or placebo 14 days. Results Mean changes complete blood count, liver enzymes, glucose levels, lipid parameters, kidney function, c-reactive protein (CRP) not significantly different between groups. There was improvement health status, including dry cough, sputum ague, sore throat, weakness, muscular pain, headache, dyspnea at week 2 both groups ( P value < 0.05); however, weakness more group than 025). Conclusion The present results showed that co-supplementation could reduce weakness. However, study, affect other indices, biochemical indices. Trial registration Iranian Registry Clinical Trials IRCT20121216011763N46 . 2020-10-31

Language: Английский

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Effect of nano‐curcumin on various diseases: A comprehensive review of clinical trials

BioFactors, Journal Year: 2023, Volume and Issue: 49(3), P. 512 - 533

Published: Jan. 6, 2023

Abstract The antioxidant, anti‐inflammatory, and antibacterial properties of curcumin have made it a valuable herbal product for improving various disorders, such as COVID‐19, cancer, depression, anxiety, osteoarthritis, migraine, diabetes. Recent research has demonstrated that encapsulating in nanoparticles might improve its therapeutic effects bioavailability. To our knowledge, the efficacy nano‐curcumin on different aspects health disease not been summarized study. Therefore, this review aimed to evaluate nano‐curcumin's diseases based findings clinical trials. In order publications focusing nanocurcumin's impact diseases, four databases were searched, including PubMed, Scopus, Web Science, Google Scholar. This highlights potential benefits wide range human neurological chronic disease, oral metabolic syndrome, other especially an adjunct standard therapy healthy lifestyle.

Language: Английский

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Antiviral, anti-inflammatory and antioxidant effects of curcumin and curcuminoids in SH-SY5Y cells infected by SARS-CoV-2

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: May 10, 2024

COVID-19, caused by SARS-CoV-2, affects neuronal cells, causing several symptoms such as memory loss, anosmia and brain inflammation. Curcuminoids (Me08 e Me23) curcumin (CUR) are derived from Curcuma Longa extract (EXT). Many therapeutic actions have been linked to these compounds, including antiviral action. Given the severe implications of especially within central nervous system, our study aims shed light on potential curcuminoids against SARS-CoV-2 infection, particularly in cells. Here, we investigated effects CUR, EXT, Me08 Me23 human neuroblastoma SH-SY5Y. We observed that significantly decreased expression plasma membrane-associated transmembrane protease serine 2 (TMPRSS2) TMPRSS11D, consequently mitigating elevated ROS levels induced SARS-CoV-2. Furthermore, exhibited antioxidative properties increasing NRF2 gene restoring NQO1 activity following infection. Both effectively reduced replication SH-SY5Y cells overexpressing ACE2 (SH-ACE2). Additionally, all compounds demonstrated ability decrease proinflammatory cytokines IL-6, TNF-α, IL-17, while specifically INF-γ levels. Our findings suggest curcuminoid could serve a agent for impact context system involvement.

Language: Английский

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Innovative Delivery Systems for Curcumin: Exploring Nanosized and Conventional Formulations

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(5), P. 637 - 637

Published: May 9, 2024

Curcumin, a polyphenol with rich history spanning two centuries, has emerged as promising therapeutic agent targeting multiple signaling pathways and exhibiting cellular-level activities that contribute to its diverse health benefits. Extensive preclinical clinical studies have demonstrated ability enhance the potential of various bioactive compounds. While reported advantages are manifold, predominantly attributed antioxidant anti-inflammatory properties, efficacy is hindered by poor bioavailability stemming from inadequate absorption, rapid metabolism, elimination. To address this challenge, nanodelivery systems approach, offering enhanced solubility, biocompatibility, effects for curcumin. We analyzed knowledge on curcumin nanoencapsulation synergistic other compounds, extracted electronic databases. discuss pharmacokinetic profile curcumin, current advancements in techniques, combined agents across disorders. By unifying existing knowledge, analysis intends provide insights into technologies overcome constraints associated treatments, emphasizing importance combinatorial approaches improving efficacy. Finally, compilation study data aims inform inspire future research encapsulating drugs characteristics investigating innovative drug combinations improve outcomes.

Language: Английский

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Immune-Boosting and Antiviral Effects of Antioxidants in COVID-19 Pneumonia: A Therapeutic Perspective

Life, Journal Year: 2025, Volume and Issue: 15(1), P. 113 - 113

Published: Jan. 16, 2025

The COVID-19 pandemic caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has profoundly impacted global health, with pneumonia emerging as a major complication in severe cases. pathogenesis of is marked the overproduction reactive oxygen species (ROS) and an excessive inflammatory response, resulting oxidative stress significant tissue damage, particularly respiratory system. Antioxidants have garnered considerable attention for their potential role managing mitigating modulating immune responses. This review provides comprehensive overview literature on use antioxidants hospitalized patients mild-to-moderate COVID-19. Studies exploring antioxidants, including vitamins, trace elements, nitric oxide (NO), ozone (O3), glutathione (GSH), L-carnitine, melatonin, bromelain, N-acetylcysteine (NAC), numerous polyphenols, yielded promising outcomes. Through ROS-scavenging properties, these molecules support endothelial function, reduce thrombosis risk, may help mitigate effects cytokine storm, key contributor to morbidity mortality. Clinical evidence suggests that antioxidant supplementation improve patient outcomes decreasing inflammation, supporting cell potentially shortening recovery times. Furthermore, symptoms exerting direct antiviral inhibit infection process genomic replication SARS-CoV-2 host cells. Moreover, work synergistically standard treatments viral-induced damage. By integrating findings from real-world data our clinical experience, we gain more profound understanding pneumonia. Further research combining reviews analysis crucial validate efficacy establish evidence-based guidelines practice.

Language: Английский

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