Metabolite profiles and DNA methylation in metabolic syndrome: a two-sample, bidirectional Mendelian randomization DOI Creative Commons
Alana Jones, Zsuzsanna Ament, Amit Patki

et al.

Frontiers in Genetics, Journal Year: 2023, Volume and Issue: 14

Published: Sept. 15, 2023

Introduction: Metabolic syndrome (MetS) increases the risk of cardiovascular disease and death. Previous ‘-omics’ studies have identified dysregulated serum metabolites aberrant DNA methylation in setting MetS. However, relationship between metabolome epigenome not been elucidated. In this study, we associated with MetS methylation, conducted bidirectional Mendelian randomization (MR) to assess causal relationships methylation. Methods: We leveraged metabolomic genomic data from a national United States cohort older adults (REGARDS), as well metabolomic, epigenomic, family-based study hypertension (HyperGEN). metabolite profiling for REGARDS using weighted logistic regression models validated them HyperGEN. Validated were selected which fit linear mixed six CpG sites previously linked Statistically significant metabolite-CpG pairs two-sample, MR. Results: Forward MR indicated that glucose serine on near CPT1A [B(SE): −0.003 (0.002), p = 0.028 B(SE): 0.029 (0.011), 0.030, respectively] ABCG1 −0.008(0.003), 0.006] SREBF1 −0.009(0.004), 0.018] , suggested protective effect serine. Reverse showed cg06500161 ( ) −1.534 (0.668), 0.023]. Discussion: The may contribute epigenetic modifications.

Language: Английский

The interplay of metabolic and epigenetic players in disease development DOI

Pallavi Chakraborty,

Chandrama Mukherjee

Biochemical and Biophysical Research Communications, Journal Year: 2024, Volume and Issue: 734, P. 150621 - 150621

Published: Aug. 29, 2024

Language: Английский

Citations

2
Lipid metabolism, amino acid metabolism, and prostate cancer: a crucial metabolic journey DOI Creative Commons
Lin Chen, Yuxin Xu,

Yuanshuo Wang

et al.

Asian Journal of Andrology, Journal Year: 2023, Volume and Issue: 26(2), P. 123 - 134

Published: Dec. 26, 2023

Prostate cancer (PCa) is one of the most common malignancies in males worldwide, and its development progression involve regulation multiple metabolic pathways. Alterations lipid metabolism affect proliferation metastatic capabilities PCa cells. Cancer cells increase synthesis regulate fatty acid oxidation to meet their growth energy demands. Similarly, changes occur amino PCa. exhibit an increased demand for specific acids, they transport pathways fulfill survival requirements. These are closely associated with disease treatment response Therefore, a comprehensive investigation characteristics expected offer novel insights approaches early diagnosis this disease.

Language: Английский

Citations

6
Simvastatin prevents BMP-2 driven cell migration and invasion by suppressing oncogenic DNMT1 expression in breast cancer cells DOI
Pooja Yadav,

Shreetama Bandyopadhayaya,

Sneha Soni

et al.

Gene, Journal Year: 2023, Volume and Issue: 882, P. 147636 - 147636

Published: July 11, 2023

Language: Английский

Citations

4
Kinesin family member 3A induces related diseases via wingless-related integration site/β-catenin signaling pathway DOI Creative Commons
Shupeng Liu, Yang He,

Shifeng Li

et al.

Science Progress, Journal Year: 2023, Volume and Issue: 106(1)

Published: Jan. 1, 2023

Kinesin family member 3A is an important motor protein that participates in various physiological and pathological processes, including normal tissue development, homeostasis maintenance, tumor infiltration, migration. The wingless-related integration site/β-catenin signaling pathway essential for critical molecular mechanisms such as embryonic organogenesis, regeneration, carcinogenesis. Recent studies have examined the of kinesin 3A, among which has gained attention. interaction between compact complex but fascinating worthy further study. upregulation downregulation influence many diseases patient survival through pathway. Therefore, this review mainly focuses on describing pathways their associated diseases.

Language: Английский

Citations

3
Metabolite profiles and DNA methylation in metabolic syndrome: a two-sample, bidirectional Mendelian randomization DOI Creative Commons
Alana Jones, Zsuzsanna Ament, Amit Patki

et al.

Frontiers in Genetics, Journal Year: 2023, Volume and Issue: 14

Published: Sept. 15, 2023

Introduction: Metabolic syndrome (MetS) increases the risk of cardiovascular disease and death. Previous ‘-omics’ studies have identified dysregulated serum metabolites aberrant DNA methylation in setting MetS. However, relationship between metabolome epigenome not been elucidated. In this study, we associated with MetS methylation, conducted bidirectional Mendelian randomization (MR) to assess causal relationships methylation. Methods: We leveraged metabolomic genomic data from a national United States cohort older adults (REGARDS), as well metabolomic, epigenomic, family-based study hypertension (HyperGEN). metabolite profiling for REGARDS using weighted logistic regression models validated them HyperGEN. Validated were selected which fit linear mixed six CpG sites previously linked Statistically significant metabolite-CpG pairs two-sample, MR. Results: Forward MR indicated that glucose serine on near CPT1A [B(SE): −0.003 (0.002), p = 0.028 B(SE): 0.029 (0.011), 0.030, respectively] ABCG1 −0.008(0.003), 0.006] SREBF1 −0.009(0.004), 0.018] , suggested protective effect serine. Reverse showed cg06500161 ( ) −1.534 (0.668), 0.023]. Discussion: The may contribute epigenetic modifications.

Language: Английский

Citations

3