International Journal of Food Sciences and Nutrition,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 11
Published: May 4, 2025
Taurine
is
recognised
for
its
neuroprotective
effects,
however,
potential
role
on
cognition
remains
controversial.
A
meta-analysis
of
randomised
controlled
trials
(RCTs)
was
conducted
to
evaluate
the
effects
taurine
in
both
cognitively
impaired
and
non-impaired
populations.
Electronic
databases
searched
up
January
2025
according
eligibility
criteria.
total
7
RCTs
with
9
intervention
involving
402
individuals
were
included.
Taurine,
administered
alone
or
combination
exercise
training,
did
not
exhibit
significant
cognitive
scores.
Compared
therapeutic
drugs
alone,
produce
greater
improvements
performance,
subgroup
analysis
indicated
that
this
resulted
enhancements
Mini-Mental
State
Examination
(WMD
=
3.09,
95%
CI:
2.29-3.90).
Overall,
findings
present
do
provide
sufficient
evidence
support
efficacy
supplementation
enhancing
function.
Nutritional Neuroscience,
Journal Year:
2022,
Volume and Issue:
26(11), P. 1090 - 1102
Published: Oct. 12, 2022
Background:
Obesity
constitutes
a
risk
factor
for
cognitive
impairment.
In
rodent
models,
long-term
exposure
to
obesogenic
diets
leads
hippocampal
taurine
accumulation.
Since
has
putative
cyto-protective
effects,
accumulation
in
obese
and
diabetic
models
might
constitute
counteracting
response
metabolic
stress.
Objective:
We
tested
the
hypothesis
that
treatment
with
or
N-acetylcysteine
(NAC),
which
provides
cysteine
synthesis
of
glutathione,
prevent
high-fat
diet
(HFD)-associated
alterations
memory
Methods:
Female
mice
were
fed
either
regular
HFD.
Some
had
access
3%(w/v)
NAC
drinking
water.
After
2
months,
magnetic
resonance
spectroscopy
(MRS)
was
used
measure
metabolite
profiles.
Memory
assessed
novel
object
location
recognition
tests.
Results:
HFD
feeding
caused
impairment
both
tests,
reduced
concentration
lactate,
phosphocreatine-to-creatine
ratio,
neuronal
marker
N-acetylaspartate
hippocampus.
Taurine
prevented
HFD-induced
reduction.
NAC,
but
not
taurine,
reduction
lactate
ratio.
MRS
revealed
NAC/taurine-induced
increase
glutamate
GABA
levels.
Conclusion:
can
impairment,
while
only
prevents
concentrations
HFD-exposed
female
mice.
Nutrients,
Journal Year:
2022,
Volume and Issue:
14(18), P. 3716 - 3716
Published: Sept. 9, 2022
Insulin
resistance
is
a
complex
condition
in
which
the
body
does
not
respond
adequately
to
insulin,
hormone
secreted
by
pancreas
with
an
essential
role
regulation
of
blood
sugar
levels
[...].
Reviews in the Neurosciences,
Journal Year:
2023,
Volume and Issue:
34(8), P. 915 - 932
Published: July 6, 2023
The
transsulfuration
pathway
(TSP)
is
a
metabolic
involving
sulfur
transfer
from
homocysteine
to
cysteine.
Transsulfuration
leads
many
metabolites,
principally
glutathione,
H2S,
taurine,
and
Key
enzymes
of
the
TSP,
such
as
cystathionine
β-synthase
γ-lyase,
are
essential
regulators
at
multiple
levels
in
this
pathway.
TSP
metabolites
implicated
physiological
processes
central
nervous
system
other
tissues.
important
controlling
balance
optimal
cellular
functions
glutathione
synthesis.
Alterations
related
pathways
(transmethylation
remethylation)
altered
several
neurodegenerative
diseases,
including
Parkinson's
disease,
suggesting
their
participation
pathophysiology
progression
these
diseases.
In
disease
comprised
mainly
those
that
regulate
redox
homeostasis,
inflammation,
reticulum
endoplasmic
stress,
mitochondrial
function,
oxidative
content
involved
damage
processes.
Current
research
on
has
primarily
focused
synthesis
function
certain
particularly
glutathione.
However,
our
understanding
regulation
pathway,
well
relationships
with
Parkinson´s
remain
limited.
Thus,
paper
highlights
importance
studying
molecular
dynamics
different
affect
disease.
Life,
Journal Year:
2025,
Volume and Issue:
15(2), P. 295 - 295
Published: Feb. 13, 2025
Brain
function
declines
because
of
aging
and
several
metabolites
change
their
concentration.
However,
this
decrease
may
be
a
consequence
or
driver
aging.
It
has
been
described
that
taurine
levels
with
age
supplementation
increases
health
span
in
mice
monkeys,
finding
as
The
frontal
cortex
is
one
the
most
key
areas
studied
to
know
normal
processes
cerebral
aging,
due
its
relevant
role
cognitive
processes,
emotion,
motivation.
In
present
work,
we
analyzed
by
intracerebral
microdialysis
vivo
prefrontal
young
(3
months)
old
(24
awake
rats,
basal-
K+-evoked
release
taurine,
precursors
methionine
serine.
taurine/serine/methionine
(TSM)
ratio
was
also
calculated
an
index
transmethylation
reactions.
No
changes
were
found
basal
serine,
between
aged
animals.
On
contrary,
significant
serine
appeared
rats
when
compared
seen
methionine.
TSM
decreased
both
K+-stimulated
conditions.
Therefore,
related
precursor
animals
under
but
not
conditions,
which
supports
importance
decline
evoked
functions
at
brain
level,
supporting
idea
proposed
other
authors
pharmacological
and/or
nutritional
intervention
restoration.
A
deficit
for
reactions
considered.
Cardiology in Review,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 19, 2025
Aging
is
a
multifaceted
biological
process
characterized
by
progressive
physiological
decline
and
increased
susceptibility
to
diseases.
Central
this
are
molecular
cellular
changes
that
contribute
hallmark
features
of
aging,
including
mitochondrial
dysfunction,
genomic
instability,
telomere
attrition,
senescence.
Emerging
research
highlights
the
role
nutrient
deficiencies
in
accelerating
bringing
dietary
supplements
such
as
taurine
berberine
into
focus.
Taurine,
sulfur-containing
amino
acid,
plays
critical
protection,
osmoregulation,
antioxidant
defense,
with
evidence
linking
its
deficiency
senescence,
stem
cell
exhaustion.
Berberine,
an
isoquinoline
alkaloid,
exerts
antiaging
effects
modulating
key
signaling
pathways,
adenosine
monophosphate-activated
protein
kinase/mechanistic
target
rapamycin
sirtuin
1,
promoting
mitohormesis.
This
review
explores
mechanisms
which
mitigate
aging
processes,
highlighting
their
on
metabolism,
stress
response,
longevity.
Animal
studies
demonstrate
potential
enhance
health
span
lifespan
although
human
clinical
trials
remain
limited.
Future
should
focus
elucidating
evaluating
combined
other
interventions
caloric
restriction,
optimizing
dosage
for
applications.
Taurine
represent
promising
therapeutic
candidates
addressing
fundamental
aspects
advancing
strategies
healthy
extension.
Journal of Periodontology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 28, 2025
Abstract
Background
Periodontitis
is
a
chronic
inflammatory
condition
that
affects
the
supporting
structures
of
teeth.
It
closely
associated
with
oxidative
stress
and
inflammation.
Taurine,
semi‐essential
amino
acid
recognized
for
its
antioxidant
anti‐inflammatory
properties,
has
not
been
extensively
investigated
in
context
periodontitis.
This
pilot
study
sought
to
evaluate
levels
taurine
cytokines,
including
interleukin‐1
beta
(IL‐1β),
interleukin‐6
(IL‐6),
tumor
necrosis
factor‐alpha
(TNF‐α),
gingival
crevicular
fluid
(GCF)
individuals
Methods
Systemically
healthy
participants
periodontitis
periodontally
were
enrolled.
GCF
samples
collected,
clinical
periodontal
parameters
such
as
bleeding
on
probing
(BOP),
attachment
loss
(CAL),
plaque
index
(PI),
depth
(PD)
documented.
The
taurine,
TNF‐α,
IL‐1ß,
IL‐16
quantified
using
enzyme‐linked
immunosorbent
assay
(ELISA).
Results
case‐control
included
40
individuals,
divided
into
2
groups:
20
stage
III,
grade
B
generalized
group
exhibited
significantly
higher
than
(
p
<
0.05).
Taurine
lower,
while
TNF‐α
No
significant
differences
between
groups
found
IL‐6
IL‐1β
>
A
moderate
positive
correlation
was
observed
BOP
r
=
0.581,
0.007).
Conclusions
These
findings
indicated
increased
health.
Plain
Language
Summary
serious
disease
gums
can
lead
teeth
by
destruction
tissues.
potential
link
naturally
occurring
compound
We
measured
inflammation‐related
proteins
gum
from
those
Subjects
had
lower
protein
compared
gums,
suggesting
could
be
involved
inflammation
processes
