Could the ketogenic diet offer hope in management of neurological diseases? DOI Creative Commons
Büşra Atabilen, Yasemin Akdevelioğlu

Published: Feb. 13, 2025

The ketogenic diet (KD) is a nutritional model that includes high fat, moderate protein, and low carbohydrate (less than 50 g). “KD ratio” used to determine the amount of macronutrients in diet. In classical KD with ratio 3:1 or 4:1, 85–90% energy provided from dietary fat. addition KD, modified Atkins diet, glycemic index therapy, medium-chain triglyceride have also been used, some studies, ketosis has achieved exogenous ketone supplements. long recognized as successful approach treatment refractory epilepsy. It known may be effective other neurological diseases such Alzheimer’s disease, Parkinson’s multiple sclerosis, migraine through various mechanisms providing an alternative source for neurons, reducing inflammation oxidative stress, stimulating neurotransmitter synthesis regulation microbiota, etc. However, existing evidence insufficient make definitive conclusions about effect on epilepsy due short intervention time, small sample size, heterogeneity study methods. Considering factors genetics, endocrine differences, timing, composition, it important apply follow precision nutrition programs increase benefits reduce its side effects. this review, diseases, recent use epilepsy, limitations difficulties literature contraindications were discussed detail.

Language: Английский

Ketone bodies mediate alterations in brain energy metabolism and biomarkers of Alzheimer’s disease DOI Creative Commons
Matin Ramezani, Malika Fernando, Shaun Eslick

et al.

Frontiers in Neuroscience, Journal Year: 2023, Volume and Issue: 17

Published: Nov. 16, 2023

Alzheimer’s disease (AD) is the most common form of dementia. AD a progressive neurodegenerative disorder characterized by cognitive dysfunction, including learning and memory deficits, behavioral changes. Neuropathology hallmarks such as amyloid beta (Aβ) plaques neurofibrillary tangles containing neuron-specific protein tau associated with changes in fluid biomarkers Aβ, phosphorylated (p-tau)-181, p-tau 231, 217, glial fibrillary acidic (GFAP), neurofilament light (NFL). Another pathological feature neural damage hyperactivation astrocytes, that can cause increased pro-inflammatory mediators oxidative stress. In addition, reduced brain glucose metabolism mitochondrial dysfunction appears up to 15 years before onset clinical symptoms. As utilization compromised patients AD, ketone bodies (KBs) may serve an alternative source energy. KBs are generated from β-oxidation fatty acids, which enhanced following consumption ketogenic diets high fat, moderate protein, low carbohydrate. have been shown cross blood barrier improve energy metabolism. This review comprehensively summarizes current literature on how increasing support for first time, this discusses effects diet putative (mainly 181), GFAP, NFL, role neuroinflammation, stress,

Language: Английский

Citations

12
A Review of Ketogenic Dietary Therapies for Epilepsy and Neurological Diseases: A Proposal to Implement an Adapted Model to Include Healthy Mediterranean Products DOI Creative Commons
Cinzia Ferraris, Monica Guglielmetti, Lenycia de Cassya Lopes Neri

et al.

Foods, Journal Year: 2023, Volume and Issue: 12(9), P. 1743 - 1743

Published: April 22, 2023

Based on the growing evidence of therapeutic role high-fat ketogenic dietary therapies (KDTs) for neurological diseases and protective effect Mediterranean diet (MD), it could be important to delineate a version KDTs in order maintain high ratio, thus avoid side effects, especially patients requiring long-term treatment. This narrative review aims explore existing literature this topic elaborate recommendations KDTs. It presents practical suggestions based MD principles, which consist key elements selection foods (both from quantitative qualitative prospective), indications relative proportions consumption frequency main food groups that constitute We suggest adoption diets benefit multiple effects MD. translates to: (i) preferential use olive oil vegetable fat sources general; (ii) limitation rich saturated fatty acids; (iii) encouragement biological value protein sources; (iv) inserting fruit vegetables at every meal possible, varying their choices according seasonality.

Language: Английский

Citations

11
Forecasting migraine attacks by managing daily lifestyle: a systematic review as a basis to develop predictive algorithms DOI Creative Commons

Umberto Quartetti,

Filippo Brighina, Giuditta Gambino

et al.

PAIN Reports, Journal Year: 2025, Volume and Issue: 10(2), P. e1247 - e1247

Published: Feb. 5, 2025

Abstract Recent studies attempting to develop forecasting models for new migraine attack onsets, overviewing triggers and protectors, are encouraging but necessitate further improvements produce with high predictive accuracy. This updated review of available data holds the potential enhance precision predicting a attack. study aims evaluate how lifestyle factors affect frequency in adults episodic migraine, contribute development an effective model. A comprehensive search databases, including PubMed, ScienceDirect, Google Scholar, Scopus, was conducted considering published from 2018 December 2023, following PRISMA guidelines. Critical evaluation using Joanna Briggs Institute's appraisal tools. The modifications examined this included dietary habits, physical activity, sleep, stress management. Of 36 analysed, which predominantly exhibited low moderate bias, 18 investigated 7 explored 11 assessed management, 5 sleep patterns. evidence these advocates implementation Furthermore, outcomes carry valuable implications standpoint models. most consistent results were observed relation specific diets, supplements, activity. Although trends noted management research is required elucidate their influence on integration into registered PROSPERO (ID CRD42024511300).

Language: Английский

Citations

0
Keto-Therapy: Unveiling the Potential of Ketogenic Diet in Psychiatric Care - A Scoping Review DOI
Margherita Boltri, Alberto Scalia, Federico Brusa

et al.

Nutrition, Journal Year: 2025, Volume and Issue: unknown, P. 112710 - 112710

Published: Feb. 1, 2025

Language: Английский

Citations

0
Could the ketogenic diet offer hope in management of neurological diseases? DOI Creative Commons
Büşra Atabilen, Yasemin Akdevelioğlu

Published: Feb. 13, 2025

The ketogenic diet (KD) is a nutritional model that includes high fat, moderate protein, and low carbohydrate (less than 50 g). “KD ratio” used to determine the amount of macronutrients in diet. In classical KD with ratio 3:1 or 4:1, 85–90% energy provided from dietary fat. addition KD, modified Atkins diet, glycemic index therapy, medium-chain triglyceride have also been used, some studies, ketosis has achieved exogenous ketone supplements. long recognized as successful approach treatment refractory epilepsy. It known may be effective other neurological diseases such Alzheimer’s disease, Parkinson’s multiple sclerosis, migraine through various mechanisms providing an alternative source for neurons, reducing inflammation oxidative stress, stimulating neurotransmitter synthesis regulation microbiota, etc. However, existing evidence insufficient make definitive conclusions about effect on epilepsy due short intervention time, small sample size, heterogeneity study methods. Considering factors genetics, endocrine differences, timing, composition, it important apply follow precision nutrition programs increase benefits reduce its side effects. this review, diseases, recent use epilepsy, limitations difficulties literature contraindications were discussed detail.

Language: Английский

Citations

0