Complex anti-relapse therapy of various variants of the course of the vulvar lichen sclerosus: A randomized prospective study DOI Creative Commons

Е. В. Колесникова,

Alexandr V. Zharov,

Natalia V. Mingaleva

et al.

GYNECOLOGY, Journal Year: 2024, Volume and Issue: 26(2), P. 176 - 184

Published: June 10, 2024

Aim. To develop and evaluate the effectiveness of complex therapy vulvar lichen sclerosus (VLS), considering clinical immunological variant (CIV) disease. Materials methods. A randomized prospective study included 292 patients 20-70 years old with different CIVs VLS course: atrophic (n=101), sclerosing (n=154), scleroatrophic (n=37), as well 35 females in comparison group same age category. Based on clinical, immunological, morphological features course, a anti-relapse was developed, which evaluated after year follow-up standard care (SoC) (from group) based number disease relapses results Vulvar Quality Life Index Questionnaire (VQLI) survey women diseases. Results. In VLS, short courses topical glucocorticoids during exacerbations are justified; – calcineurin inhibitors, protein-peptide from porcine blood leukocytes (vaginal suppositories cream-balsam lanolin) containing interleukin-1, 6, tumor necrosis factor α, transforming growth factor, macrophage migration inhibitory factor. Patients any instructed to follow household hygienic recommendations, use emollients daily, take prophylactic doses vitamins A, E, D correct its deficiency or insufficiency, local enzyme therapy, indicated, aimed at preventing treatment cicatricial changes. Local estrogens were prescribed only genitourinary menopausal syndrome peri- postmenopausal period. The developed showed greater efficacy compared SoC: 3.7-fold decrease episodes exacerbation, significant (p=0.001) 1.3-fold negative effect QoL main (15.4 points according VQLI assessment mild QoL) SoC average score 27.6, corresponded strong QoL. Conclusion. support distinction need consider their when choosing an effective for Properly selected complex, supportive can significantly increase patients, minimize relapses, prevent development complications, including, probably, risk malignant transformation.

Language: Английский

Integrative and Mechanistic Approach to the Hair Growth Cycle and Hair Loss DOI Open Access
Nicole Natarelli,

Nimrit Gahoonia,

Raja K. Sivamani

et al.

Journal of Clinical Medicine, Journal Year: 2023, Volume and Issue: 12(3), P. 893 - 893

Published: Jan. 23, 2023

The hair cycle is composed of four primary phases: anagen, catagen, telogen, and exogen. Anagen a highly mitotic phase characterized by the production shaft from follicle, whereas catagen telogen describe regression resting respectively, ultimately resulting in shedding. While 9% follicles reside at any time, variety factors promote anagen to transition, including inflammation, hormones, stress, nutritional deficiency, poor sleep quality, cellular division inhibiting medication. Conversely, increased blood flow, direct stimulation growth transition subsequent growth. This review seeks comprehensively cycle, balance, that vice versa, clinical utility lab testing evaluations. Ultimately, impact necessitating holistic approach loss.

Language: Английский

Citations

58
Role of Antioxidants in Skin Aging and the Molecular Mechanism of ROS: A Comprehensive Review DOI Creative Commons

Narmin Hama amin Hussen,

Sakar Karem Abdulla,

Nasir Ali

et al.

Aspects of Molecular Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 100063 - 100063

Published: Jan. 1, 2025

Language: Английский

Citations

8
Applications of MXene and its modified materials in skin wound repair DOI Creative Commons
Ziyan Zhang, Zhiping Qi, Weijian Kong

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2023, Volume and Issue: 11

Published: March 13, 2023

The rapid healing and repair of skin wounds has been receiving much clinical attention. Covering the wound with dressing to promote is currently main treatment for repair. However, performance prepared by a single material limited cannot meet requirements complex conditions healing. MXene new two-dimensional electrical conductivity, antibacterial photothermal properties other physical biological properties, which wide range applications in field biomedicine. Based on pathophysiological process ideal dressing, this review will introduce preparation modification methods MXene, systematically summarize application status mechanism healing, provide guidance subsequent researchers further apply design dressing.

Language: Английский

Citations

21
Nutritional Supplements for Skin Health—A Review of What Should Be Chosen and Why DOI Creative Commons
Jacek Januszewski, Alicja Forma, Julita Zembala

et al.

Medicina, Journal Year: 2023, Volume and Issue: 60(1), P. 68 - 68

Published: Dec. 29, 2023

Supplementation of micronutrients is considered to be crucial in the reinforcement skin’s barrier. In this paper, 14 nutritional compounds commonly used food or pharmaceutic industries were analyzed terms influencing skin conditions. The major objective paper was provide a narrative review available literature regarding several chosen that are currently widely recommended as supplements aim maintain proper and healthy We conducted from PubMed, Scopus, Web Science until September 2023 without any other restrictions year publication. Ultimately, we reviewed 238 articles, including them review. Each compounds, vitamin A, C, D, E, curcumin, chlorella, Omega-3, biotin,Ppolypodium leucotomos, Simmondsia chinesis, gamma oryzanol, olive leaf extract, spirulina, astaxanthin, observed present some possible effects with promising benefits for condition, i.e., photoprotective radiation. Adding diet daily routine might have positive influence on inflammatory diseases such atopic dermatitis psoriasis. Further, UV radiation protection facilitated by their impact human cells helpful during chemotherapy preventing melanoma development. Further research needed because lack clear consensus doses described could desirable skin.

Language: Английский

Citations

17
The role of vitamins and nutrients in rosacea DOI Creative Commons
Yanci A. Algarin, Anika Pulumati, Dana Jaalouk

et al.

Archives of Dermatological Research, Journal Year: 2024, Volume and Issue: 316(5)

Published: May 2, 2024

Language: Английский

Citations

5
Electrochemical Nanosensors: Revolutionizing Vitamin Detection DOI
Surbhi Sharma, Shagun Gupta, Adesh K. Saini

et al.

Talanta, Journal Year: 2025, Volume and Issue: 291, P. 127830 - 127830

Published: Feb. 25, 2025

Language: Английский

Citations

0
Vitamin A–associated onycholysis DOI
S Long, Peyton Harris, Ronnie Youssef

et al.

Baylor University Medical Center Proceedings, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 3

Published: Feb. 27, 2025

Onycholysis is a disorder of the nails, described as separation nail bed from plate. While onycholysis most commonly occurs due to trauma nail, such after manicures or chemical exposure, it can also result drug-induced photosensitivity. Many medications have been linked onycholysis, including tetracyclines, psoralens, and retinoids, which are synthetic derivatives vitamin A. Oral retinoid use has associated with various changes, but there no reports resulting oral A intake. Thus, we present case an 85-year-old woman who presented distal fingernails, lifting ends. She was prescribed 5-day course 10,000 units twice daily lumbar laminectomy; however, she continued over-the-counter supplementation for 2 months prescription completion. Given this patient's history prolonged intake, her symptom improvement upon supplement cessation, documented other changes caused by isotretinoin, believe that unreported adverse effect therapy.

Language: Английский

Citations

0
Gut-Skin Axis: Unraveling the Role of Vitamins in Skin Health DOI Creative Commons

M. Sharma,

N. M. Malik

IntechOpen eBooks, Journal Year: 2025, Volume and Issue: unknown

Published: March 7, 2025

The disruption of the skin barrier and immune function has been linked to several conditions, including atopic dermatitis (AD), psoriasis, acne. Both resident non-resident cells, along with skin’s system, play crucial roles in innate immunity. Recent research on microbiota enhanced our understanding interactions between these microorganisms cells. Vitamins, as essential micronutrients, have shown possess antioxidant, anti-inflammatory, antimicrobial properties. immunomodulatory effects vitamins may help prevent progression diseases, making it important explore their immunopharmacology, particularly relation conditions. Additionally, is necessary investigate molecular cellular markers influenced by derivatives. This review focuses key (A, B, C, D, E) taken nutritional supplements, examining findings potential implications for immunity, health, disease.

Language: Английский

Citations

0
Combating Methotrexate Resistance in Cancer Treatment: A Review on Navigating Pathways and Enhancing Its Efficacy With Fat‐Soluble Vitamins DOI Creative Commons

Muhsina Kakkadath,

D. Subbaram Naidu,

S. K. Kanthlal

et al.

Scientifica, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

Methotrexate (MTX), a potent analogue and antagonist of folic acid, is first‐line treatment for rheumatoid arthritis, IBD cancer. The development MTX resistance contributes to the reduced efficacy adverse reactions, forcing clinicians withdraw early. This drawback requires combinational approaches combat enhance safety MTX. To provide brief overview strategies mitigate its aftereffects in cancer therapy, literature‐based search was conducted using keywords such as pathology, mechanism resistance, S100A4, folate uptake, efflux, P‐glycoprotein, beta‐catenin anticancer properties Vitamins A, D, E K. Investigations encompassing vitro studies, vivo studies clinical trials were reviewed identify mechanisms induced by potential benefits coadministering fat‐soluble vitamins with existing drugs. Derivates Vitamin A could target stem cells increase chemotherapy sensitivity non–small cell lung Similarly, calcitriol cytotoxic medications exhibit additive or synergistic effects. Existing research revealed that can inhibit drug transporters, which improving As personalised medicine continues evolve, incorporating combination holds promise enhancing efficacy, counteract via multiple pathways improve profile.

Language: Английский

Citations

0
A Single Center Blinded, Placebo Controlled Study Evaluating Cosmetic Efficacy and Safety of a Novel Topical GLPSGLT in GLP-1 Analog Treated Subjects DOI Creative Commons

Alec Semersky,

Sydney Pryor,

Caitlin Barwood-Parent

et al.

Aesthetic Surgery Journal Open Forum, Journal Year: 2025, Volume and Issue: 7

Published: Jan. 1, 2025

Abstract Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and Sodium-glucose cotransporter 2 (SGLT-2) inhibitors are widely used for Type diabetes weight management but may adversely affect skin quality, resulting in dermal thinning, decreased elasticity, accelerated aging—a phenomenon referred to as “GLP-1 Face.” A novel topical serum, GLPSGLT (Aforé LLC), was developed counteract these effects using a proprietary blend of bioavailable retinoic acid derivative, peptides, botanical agents support keratinocyte function repair. The authors the study aim evaluate safety efficacy serum improving facial quality patients undergoing GLP-1 RA or SGLT-2 therapy. In this split-face, double-blind pilot study, 7 female (median age 55) on stable RA/SGLT-2 therapy applied one side face placebo other, twice daily 6 weeks. Assessments at baseline, Day 21, 42 included Global Ranking Scale (GRS), standardized photography reviewed by blinded physician, 26-item patient-satisfaction questionnaire. Treated sides showed statistically significant improvements across all 13 GRS domains vs (P < .0001), particularly hydration, surface roughness, pigmentation, vasculature, visible pores, static wrinkles. reviewer correctly identified treated cases. Patients reported greater satisfaction with texture, firmness, radiance, hydration. No adverse events were reported. significantly improved RA/SGLT-2-treated well-tolerated, warranting further investigation larger, histologically assessed cohorts. Level Evidence: 4 (Therapeutic)

Language: Английский

Citations

0