bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: April 29, 2024
Abstract
Epidemiological
studies
reveal
that
a
diagnosis
of
inflammatory
bowel
disease
(IBD)
is
associated
with
an
increased
risk
developing
Parkinson’s
(PD).
The
presence
gut
dysbiosis
has
been
documented
in
both
PD
and
IBD
patients,
however
it
currently
unknown
how
alterations
the
microbiome
may
contribute
to
epidemiological
link
between
diseases.
To
identify
shared
distinct
features
microbiome,
we
performed
first
joint
analysis
54
PD,
26
IBD,
16
healthy
control
metagenomes
recruited
from
clinics
at
University
Florida,
directly
compared
microbiomes
persons.
Larger,
publicly
available
metagenomic
datasets
were
also
analyzed
validate
extend
our
findings.
Depletions
short-chain
fatty
acid
(SCFA)
producing
bacteria,
including
Roseburia
intestinalis,
Faecalibacterium
prausnitzii,
Anaerostipes
hadrus,
Eubacterium
rectale
,
as
well
depletions
SCFA
synthesis
pathways,
demonstrated
across
datasets.
We
posit
direct
comparison
will
be
important
identifying
within
which
PD.
data
revealed
consistent
depletion
SCFA-producing
bacteria
suggesting
loss
these
microbes
influence
pathophysiology
states.
LWT,
Journal Year:
2024,
Volume and Issue:
193, P. 115764 - 115764
Published: Jan. 18, 2024
Exopolysaccharides
(EPSs)
have
been
shown
to
possess
wide-ranging
of
physiological
functions,
including
antioxidant,
anticancer,
and
immunomodulatory.
However,
there
is
a
scarcity
research
focused
on
the
probiotic
function
EPSs
isolated
from
Bifidobacteria,
further
investigation
needed
reveal
mechanisms
underlying
their
functions.
In
this
study,
were
purified
Bifidobacterium
animalis
subsp.
Lactis
SF
(SF-EPS),
potential
SF-EPS
analyzed
by
in
vitro
antioxidant
capacity
assays
human
fecal
fermentation.
Followed
evaluation
eps
cluster
B.
lactis
SF.
The
results
showed
that
(MW:
4.81×104
Da)
contained
glucose,
galactose,
arabinose,
mannose
molar
ratio
4.02:1.91:1.02:1.0
small
amounts
glucuronic
acid
(0.02
±
0.01
mol%).
Furthermore,
strong
capacity,
which
was
embodied
its
ability
scavenging
DPPH
hydroxyl
radicals.
regulated
gut
microbiota
increasing
relative
abundances
Faecalibacterium,
Anaerostipes,
decreasing
abundance
Enterobacter
Klebsiella.
promoted
production
short-chain
fatty
acids
(SCFAs)
intestinal
microorganisms.
Therefore,
has
for
utilization
as
prebiotic
functional
foods,
enhancing
health,
offering
natural
ingredient
use
industrial
food
production.
Food & Function,
Journal Year:
2024,
Volume and Issue:
15(4), P. 2314 - 2326
Published: Jan. 1, 2024
A
diet
enriched
in
apple
pomace
a
DSS-induced
colitis
mice
model
ameliorated
inflammation
markers
and
disease
activity,
modulated
the
intestinal
microbiota.
Frontiers in Microbiology,
Journal Year:
2025,
Volume and Issue:
15
Published: Jan. 22, 2025
Numerous
studies
have
confirmed
that
gut
microbiota
is
a
key
driver
in
the
occurrence
and
progression
of
inflammatory
bowel
disease
(IBD).
Based
on
bacterial
collection
constructed
our
previous
studies,
we
founded
Bifidobacterium
adolescentis
AF91-08b2A
has
potential
beneficial
function.
We
designed
cohort
genomic
animal
experiments
to
further
explore
probiotic
function
its
therapeutic
effect
IBD.
The
depletion
B.
individuals
with
IBD
suggested
significance
for
intestinal
health.
Genomic
analysis
highlighted
attributes
AF91-08b2A,
including
resistance
antibiotics
stress,
metabolic
pathways
related
energy
carbohydrate
metabolism,
which
are
likely
enhance
efficacy.
In
DSS-induced
mice
colitis
model,
strain
significantly
enhanced
activity
index
(DAI),
curbed
weight
loss,
attenuated
colonic
damage.
It
effectively
modulated
immune
response
by
reducing
levels
pro-inflammatory
cytokines
such
as
IL-6,
IL-1β,
IL-17A,
IFN-γ,
TNF-α,
while
promoting
secretion
anti-inflammatory
like
IL-4,
IL-10,
TGF-β1.
restoration
tight
junction
proteins
ZO-1,
occludin,
claudin-2
demonstrated
capacity
safeguard
epithelial
barrier.
Collectively,
findings
indicate
valuable
option
UC,
multifaceted
approach
inflammation
fortifying
npj Parkinson s Disease,
Journal Year:
2025,
Volume and Issue:
11(1)
Published: March 19, 2025
Abstract
Epidemiological
studies
reveal
that
inflammatory
bowel
disease
(IBD)
is
associated
with
an
increased
risk
of
Parkinson’s
(PD).
Gut
dysbiosis
has
been
documented
in
both
PD
and
IBD,
however
it
currently
unknown
whether
gut
underlies
the
epidemiological
association
between
diseases.
To
identify
shared
distinct
features
IBD
microbiome,
we
recruited
54
PD,
26
16
healthy
control
individuals
performed
first
joint
analysis
metagenomes.
Larger,
publicly
available
metagenomic
datasets
were
also
analyzed
to
validate
extend
our
findings.
Depletions
short-chain
fatty
acid
(SCFA)-producing
bacteria,
including
Roseburia
intestinalis,
Faecalibacterium
prausnitzii,
Anaerostipes
hadrus
,
Eubacterium
rectale
as
well
depletion
SCFA-synthesis
pathways
detected
across
datasets,
suggesting
these
microbes
may
influence
for
development.
Journal of Inflammation Research,
Journal Year:
2025,
Volume and Issue:
Volume 18, P. 5951 - 5967
Published: May 1, 2025
Inflammatory
bowel
disease
(IBD)
is
a
chronic,
relapsing
inflammatory
disorder
of
the
intestine,
frequently
complicated
by
intestinal
fibrosis.
As
fibrosis
progresses,
it
can
result
in
luminal
stricture
and
compromised
function,
significantly
diminishing
patients'
quality
life.
Emerging
evidence
suggests
that
gut
microbiota
their
metabolites
contribute
to
pathogenesis
IBD-associated
influencing
inflammation
modulating
immune
responses.
This
review
systematically
explores
mechanistic
link
between
IBD
evaluates
therapeutic
potential
traditional
Chinese
medicine
(TCM)
interventions.
Relevant
studies
were
retrieved
from
PubMed,
Web
Science,
Embase,
Scopus,
CNKI,
Wanfang,
VIP
databases.
Findings
indicate
TCM,
including
herbal
prescriptions
bioactive
constituents,
modulate
composition
microbial
metabolites,
ultimately
alleviating
through
anti-inflammatory,
immunemodulatory,
anti-fibrotic
mechanisms.
These
insights
highlight
TCM
as
promising
strategy
for
targeting
management
