A comparative analysis of Parkinson’s disease and inflammatory bowel disease gut microbiomes highlights shared depletions in key butyrate-producing bacteria DOI

Maeve E. Krueger,

Jake Boles, Zachary D. Simon

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: April 29, 2024

Abstract Epidemiological studies reveal that a diagnosis of inflammatory bowel disease (IBD) is associated with an increased risk developing Parkinson’s (PD). The presence gut dysbiosis has been documented in both PD and IBD patients, however it currently unknown how alterations the microbiome may contribute to epidemiological link between diseases. To identify shared distinct features microbiome, we performed first joint analysis 54 PD, 26 IBD, 16 healthy control metagenomes recruited from clinics at University Florida, directly compared microbiomes persons. Larger, publicly available metagenomic datasets were also analyzed validate extend our findings. Depletions short-chain fatty acid (SCFA) producing bacteria, including Roseburia intestinalis, Faecalibacterium prausnitzii, Anaerostipes hadrus, Eubacterium rectale , as well depletions SCFA synthesis pathways, demonstrated across datasets. We posit direct comparison will be important identifying within which PD. data revealed consistent depletion SCFA-producing bacteria suggesting loss these microbes influence pathophysiology states.

Language: Английский

Three specific gut bacteria in the occurrence and development of colorectal cancer: a concerted effort DOI Creative Commons

Dengmei Gong,

Amma G. Adomako-Bonsu,

Maijian Wang

et al.

PeerJ, Journal Year: 2023, Volume and Issue: 11, P. e15777 - e15777

Published: Aug. 4, 2023

Colorectal cancer (CRC), which develops from the gradual evolution of tubular adenomas and serrated polyps in colon rectum, has a poor prognosis high mortality rate. In addition to genetics, lifestyle, chronic diseases, intestinal integrity microbiota (which facilitate digestion, metabolism, immune regulation) could promote CRC development. For example, enterotoxigenic Bacteroides fragilis , genotoxic Escherichia coli (pks+ E. coli) Fusobacterium nucleatum members microbiota, are highly correlated CRC. This review describes roles mechanisms these three bacteria Their interaction during initiation progression also been proposed. Our view is that precancerous stage colorectal cancer, ETBF causes inflammation, leading potential changes ecology may provide basic conditions for pks+ colonization induction oncogenic mutations, when cancerous epithelial cells can further recruit F. colonise lesion site contribute advancement by primarily development cells, stemization, proliferation, create new tailored preventive, screening therapeutic interventions. However, there most dominant each development, not neglecting possibility two or even all be engaged at any disease. The relationship between associated gut important information strategies assess use studies, antibiotic therapy, prevention strategies.

Language: Английский

Citations

9
Depressive disorder prevention by DIET crosslink: Diet, intestinal microbiota, enzyme and traits of metabolism DOI

Yuye Gao,

Tingting Zhou

Trends in Food Science & Technology, Journal Year: 2024, Volume and Issue: 150, P. 104596 - 104596

Published: June 14, 2024

Language: Английский

Citations

3
A Ropy Exopolysaccharide-Producing Strain Bifidobacterium pseudocatenulatum Bi-OTA128 Alleviates Dextran Sulfate Sodium-Induced Colitis in Mice DOI Open Access
Hui Wang, Xinyuan Zhang,

Xinfang Kou

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(23), P. 4993 - 4993

Published: Dec. 1, 2023

Inflammatory bowel disease (IBD) is a chronic associated with overactive inflammation and gut dysbiosis. Owing to the beneficial effects of bifidobacteria on IBD treatment, this study aimed investigate anti-inflammation an exopolysaccharide (EPS)-producing strain Bifidobacterium pseudocatenulatum Bi-OTA128 through dextran sulfate sodium (DSS)-induced colitis mice model. B. treatment improved DSS-induced symptoms maintained intestinal barrier integrity by up-regulating MUC2 tight junctions’ expression. The oxidative stress was reduced after increasing antioxidant enzymes SOD, CAT, GSH-Px in colon tissues. Moreover, inflammatory responses were also inhibited decreasing pro-inflammatory cytokines TNF-α, IL-1β, IL-6, but anti-inflammatory cytokine IL-10. EPS-producing showed better than that non-EPS-producing stain BLYR01-7 modulating increased relative abundance bacteria decreased maleficent Escherichia-Shigella, Enterorhabuds, Enterobacter, Osillibacter inflammation. Notably, genera Clostridium sensu stricto only enriched Bi-OTA128-treated mice, which could degrade polysaccharides produce acetic acid butyrate gut. This finding demonstrated cross-feeding effect induced microbiota. Collectively, these results highlighted colitis, be used as candidate probiotic supporting recovery from ongoing colitis.

Language: Английский

Citations

8
Safety and efficacy of adding postbiotics in infant formula: a systematic review and meta-analysis DOI

Xifeng Liang,

Yu Li,

Zhijiao Zhao

et al.

Pediatric Research, Journal Year: 2023, Volume and Issue: 95(1), P. 43 - 51

Published: Sept. 12, 2023

Language: Английский

Citations

7
A comparative analysis of Parkinson’s disease and inflammatory bowel disease gut microbiomes highlights shared depletions in key butyrate-producing bacteria DOI

Maeve E. Krueger,

Jake Boles, Zachary D. Simon

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: April 29, 2024

Abstract Epidemiological studies reveal that a diagnosis of inflammatory bowel disease (IBD) is associated with an increased risk developing Parkinson’s (PD). The presence gut dysbiosis has been documented in both PD and IBD patients, however it currently unknown how alterations the microbiome may contribute to epidemiological link between diseases. To identify shared distinct features microbiome, we performed first joint analysis 54 PD, 26 IBD, 16 healthy control metagenomes recruited from clinics at University Florida, directly compared microbiomes persons. Larger, publicly available metagenomic datasets were also analyzed validate extend our findings. Depletions short-chain fatty acid (SCFA) producing bacteria, including Roseburia intestinalis, Faecalibacterium prausnitzii, Anaerostipes hadrus, Eubacterium rectale , as well depletions SCFA synthesis pathways, demonstrated across datasets. We posit direct comparison will be important identifying within which PD. data revealed consistent depletion SCFA-producing bacteria suggesting loss these microbes influence pathophysiology states.

Language: Английский

Citations

2