Frontiers in Nutrition,
Journal Year:
2025,
Volume and Issue:
12
Published: March 31, 2025
Objective
To
examine
the
potential
association
between
dietary
index
of
gut
microbiota
(DI-GM)
scores
and
constipation
in
adult
women
United
States.
Methods
This
cross-sectional
study
used
data
from
participants
2005–2010
US
National
Health
Survey
(NHANES).
The
missing
values
covariables
were
filled
by
multiple
interpolation.
Multivariate
logistic
regression
models
to
determine
odds
ratios
(OR)
95%
confidence
intervals
(CI)
for
DI-GM
constipation.
Subgroup
analyses
also
performed
possible
interactions
Results
Of
7,325
subjects,
887
reported
constipations,
with
a
prevalence
12.1%.
After
adjustment
multivariate
modeling,
score
was
significantly
associated
(0.92
[95%
CI
0.87–0.96];
p
=
0.001).
Similar
results
found
beneficial
(OR
0.89
0.84
0.95];
0.
001).
revealed
that
relationship
remained
stable
(
>
0.05).
Conclusion
negatively
incidence
female
population.
Clinicians
should
consider
influence
structure
on
treatment
women.
Dietary
intervention
can
be
an
important
strategy
comprehensive
International Journal of General Medicine,
Journal Year:
2025,
Volume and Issue:
Volume 18, P. 1007 - 1022
Published: Feb. 1, 2025
To
explore
the
mechanism
of
Zhuyang
Tongbian
Decoction
(ZTD)
in
treating
functional
constipation
(FC)
by
observing
its
effects
on
intestinal
flora
composition,
metabolic
function
gut
microbiota,
fecal
short-chain
fatty
acid
(SCFA)
levels,
and
serum
concentrations
TLR4,
NF-κB,
TNF-α,
IL-6
patients
with
FC.
40
FC
were
randomly
divided
into
control
group
treatment
group,
20
cases
each
group.
And
healthy
volunteers
recruited
during
same
period.
The
was
administered
lactulose,
while
treated
ZTD.
16s
RNA
sequencing
technology
used
to
compare
changes
structure
diversity
before
after
treatment.
Changes
levels
SCFAs
faeces
TNF-α
analysed.
Metagenomics
assessed
microbiota
functions.
showed
a
significant
increase
relative
abundance
beneficial
bacteria,
including
Bifidobacterium,
Lactobacillus,
Faecalibacterium_prausnitzii
(P
<
0.05),
whereas
Desulfobacterota
Ruminococcus
significantly
reduced
0.05).
Notably,
acetic
propionic
higher
Serum
biomarkers
decreased
that
Carbohydrate
metabolism,
Metabolism
cofactors
vitamins,
C5-
Branched
dibasic
metabolism
increased
ZTD
notably
improves
composition
function,
regulates
SCFA
reduces
inflammation
markers
patients.
strain
shows
potential
regulation
may
play
crucial
role
efficacy
for
Frontiers in Nutrition,
Journal Year:
2025,
Volume and Issue:
12
Published: March 13, 2025
Background
This
study
aimed
to
investigate
the
independent
and
combined
effects
of
prolonged
daily
sitting
time
sleep
duration
on
risk
constipation,
using
data
from
National
Health
Nutrition
Examination
Survey
(NHANES)
2005–2010.
Methods
A
total
6,894
participants
were
included
in
analysis.
Daily
self-reported
categorized
as
short
(<7
h/day)
or
long
(≥7
h/day).
Constipation
was
defined
based
stool
consistency
frequency
Bristol
Stool
Form
Scale.
Multivariable
logistic
regression
models
used
estimate
odds
ratios
(ORs)
for
constipation.
restricted
cubic
spline
analysis
applied
assess
dose–response
relationships.
Results
Participants
with
showed
a
higher
constipation
compared
those
time.
In
multivariable-adjusted
models,
positively
associated
an
increased
(OR
=
1.424;
95%
CI,
1.114–1.821),
while
lower
0.725;
0.553–0.952).
The
joint
revealed
that
combination
highest
prevalence
1.975;
1.378–2.833).
Conclusion
Both
insufficient
especially
when
combined.
These
findings
underscore
importance
adopting
healthier
habits
reducing
sedentary
behavior
risk.
Frontiers in Microbiology,
Journal Year:
2025,
Volume and Issue:
16
Published: March 25, 2025
Introduction
Ulcerative
colitis
(UC)
is
characterized
by
chronic
inflammation
and
ulceration
in
colonic
mucosa,
accompanied
a
defective
epithelial
barrier.
Proteus
mirabilis
(
P.
)
bacterium
putative
intestinal
pathogen
with
invasive
ability,
yet
its
role
UC
gut
barrier
disruption
unclear.
This
study
aims
to
investigate
epidemiological
presence,
pathogenic
roles
preventive
strategy
during
inflammation.
Method
culture
PCR
amplification
of
the
-specific
ureR
gene
were
used
detect
fecal
determine
prevalence
control
stool
specimens.
isolated
from
specimens
was
gavaged
into
dextran
sulfate
sodium
(DSS)-treated
mice.
Inflammation
mucus
layer
colons
assessed
through
histological
examination
cytokine
quantification.
Bacteriophages
screened
eliminate
animals.
Results
discussion
The
bacteria
detected
gene.
Of
41
patients,
65.9%
patients
positive,
which
significantly
higher
than
controls.
Administration
aggravated
DSS-induced
symptom
mucosal
Interestingly,
layer,
an
essential
component
barrier,
animals
dramatically
disrupted,
consistent
alteration
human
colon.
disrupted
mediated
down-regulation
IL-18
epithelium.
Importantly,
bacteriophage
cocktail
targeting
could
restore
alleviate
enteric
Thus,
our
results
suggest
that
pathobiont
bacterium,
exacerbates
severity
owing
mucin
production
expression.
Bacteriophage-mediated
elimination
may
be
effective
limiting
Frontiers in Nutrition,
Journal Year:
2025,
Volume and Issue:
12
Published: March 31, 2025
Objective
To
examine
the
potential
association
between
dietary
index
of
gut
microbiota
(DI-GM)
scores
and
constipation
in
adult
women
United
States.
Methods
This
cross-sectional
study
used
data
from
participants
2005–2010
US
National
Health
Survey
(NHANES).
The
missing
values
covariables
were
filled
by
multiple
interpolation.
Multivariate
logistic
regression
models
to
determine
odds
ratios
(OR)
95%
confidence
intervals
(CI)
for
DI-GM
constipation.
Subgroup
analyses
also
performed
possible
interactions
Results
Of
7,325
subjects,
887
reported
constipations,
with
a
prevalence
12.1%.
After
adjustment
multivariate
modeling,
score
was
significantly
associated
(0.92
[95%
CI
0.87–0.96];
p
=
0.001).
Similar
results
found
beneficial
(OR
0.89
0.84
0.95];
0.
001).
revealed
that
relationship
remained
stable
(
>
0.05).
Conclusion
negatively
incidence
female
population.
Clinicians
should
consider
influence
structure
on
treatment
women.
Dietary
intervention
can
be
an
important
strategy
comprehensive
