Effect of Continuous Ingestion of Bifidobacteria and Dietary Fiber on Improvement in Cognitive Function: A Randomized, Double-Blind, Placebo-Controlled Trial

Nutrients, Journal Year: 2023, Volume and Issue: 15(19), P. 4175 - 4175

Published: Sept. 27, 2023

Bifidobacterium animalis subsp. lactis GCL2505 has been shown to have some positive effects on health, including improved defecation frequency and reduced visceral fat. These are thought be due GCL2505′s unique ability reach the intestine in a viable form proliferate after single intake. This leads an increased number of intestinal bifidobacteria. randomized, double-blind, placebo-controlled, parallel-group study was conducted confirm that intake inulin (a prebiotic) improve cognitive function (n = 80). Participants consumed test drinks containing 1 × 1010 colony-forming units per 100 g 2.0 for 12 weeks. The change assessment scores set as primary endpoint. There were significant improvements neurocognitive index domain, which is overall function, addition attention, flexibility, executive domains. intervention significantly fecal bifidobacteria affected levels several inflammatory markers. results suggest improves by improving environment alleviating inflammation.

Language: Английский

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Lactobacillus gasseri NK109 and Its Supplement Alleviate Cognitive Impairment in Mice by Modulating NF-κB Activation, BDNF Expression, and Gut Microbiota Composition

Nutrients, Journal Year: 2023, Volume and Issue: 15(3), P. 790 - 790

Published: Feb. 3, 2023

Aging-related gut microbiota dysbiosis initiates inflammation and dysbiosis, which induce the occurrence of psychiatric disorders including dementia. The alleviation by probiotics is suggested to be able alleviate cognitive impairment (CI). Therefore, understand how could CI, we examined effects anti-inflammatory Lactobacillus gasseri NK109 its supplement (NS, mixture soybean embryo ethanol extract) on function in aged (Ag), 5XFAD transgenic (Tg), or mildly cognition-impaired adult fecal (MCF)-transplanted mice. Oral administration NS decreased CI-like behaviors Ag Their treatments suppressed TNF-α p16 expression NF-κB-activated cell populations hippocampus colon, while BDNF was induced. Moreover, they partially shifted β-diversity mice those young mice: Bifidobacteriaceae, Lactobacillaceae, Helicobacteriaceae increased Rikenellaceae Prevotellaceae populations. also reduced Tg induced hippocampus, hippocampal Aβ colonic Muribaculaceae Rhodospiraceae population. MCF transplantation-induced expression, decreased. These findings suggest that dementia can fluctuate composition CI with systemic inducing suppressing NF-κB activation dysbiosis.

Language: Английский

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Lactiplantibacillus plantarum as a promising adjuvant for neurological disorders therapy through the brain-gut axis and related action pathways

Critical Reviews in Food Science and Nutrition, Journal Year: 2023, Volume and Issue: 65(4), P. 715 - 727

Published: Nov. 11, 2023

Dysbiosis in neurological disorders has highlighted the gut-microbiota-brain axis and psychobiotics their ability to act on brain-gut axis. Studying discovering new approaches therapies for neuropsychiatric are strategies that have been discussed put into practice.

Language: Английский

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The effects of the interplay between vitamins, antibiotics, and gut microbiota on the pathogenesis and progression of dementia: A systematic review and meta‐analysis

Health Science Reports, Journal Year: 2024, Volume and Issue: 7(1)

Published: Jan. 1, 2024

Given that there is already evidence of a neural network connects the brain and gut microbiota actively modulates health, it crucial to know which foods, supplements, medications use or avoid when treating any disease causes dementia cognitive impairment. Previous research has examined relationships between vitamins, antibiotics, correlations these factors dementia. The question arises how three interact together if suggests one element more important than others in pathogenesis development

Language: Английский

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The Kynurenine Pathway in Gut Permeability and Inflammation

Inflammation, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 10, 2024

Language: Английский

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Curcumin suppresses colorectal tumorigenesis through restoring the gut microbiota and metabolites

BMC Cancer, Journal Year: 2024, Volume and Issue: 24(1)

Published: Sept. 12, 2024

Language: Английский

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Lactiplantibacillus plantarum HEAL9 attenuates cognitive impairment and progression of Alzheimer's disease and related bowel symptoms in SAMP8 mice by modulating microbiota-gut-inflammasome-brain axis

Food & Function, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

HEAL9 alleviates cognitive decline and normalizes colonic motility in the prodromal AD via microbiota-gut-inflammasome-brain axis. can represent a suitable therapeutical option for treatment of early related intestinal symptoms.

Language: Английский

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Exploring Nutraceutical Approaches Linking Metabolic Syndrome and Cognitive Impairment

iScience, Journal Year: 2025, Volume and Issue: 28(2), P. 111848 - 111848

Published: Jan. 23, 2025

Metabolic syndrome (MetS) and mild cognitive impairment (MCI) are interconnected conditions sharing common pathological pathways, such as inflammation oxidative stress, leading to the concept of "metabolic-cognitive syndrome." This highlights their mutual influence potential overlapping therapeutic strategies. Although lifestyle modifications remain essential, nutraceutical supplementation has emerged a promising adjunct for prevention management these preclinical conditions. review examines clinical translational evidence on commonly used nutraceuticals targeting shared pathophysiological mechanisms MetS MCI. By addressing inflammation, metabolic dysfunction, supplements may offer valuable approach mitigating progression consequences both Understanding efficacy could provide practical tools complement changes, offering more comprehensive strategy managing metabolic-cognitive syndrome.

Language: Английский

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Regulation of IL-10 production in dendritic cells is controlled by the co-activation of TLR2 and Mincle by Lactiplantibacillus plantarum OLL2712

Microbiology Spectrum, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 4, 2025

ABSTRACT We showed that Lactiplantibacillus plantarum OLL2712 (OLL2712) strongly induces interleukin (IL)-10 production in immune cells. Although beneficial effects of this strain have been observed both mice and humans, the mechanisms underlying IL-10 induction remain unclear. In study, we found co-activates two pattern recognition receptors, leading to mouse-derived thermosensitive dendritic cell line, tsDC. first revealed involvement Toll-like receptor (TLR)2-Myeloid differentiation primary response gene (MYD) 88 pathway OLL2712-induced tsDCs. However, stimulation with TLR2 agonist alone was insufficient induce production. Consequently, explored additional signaling pathways phosphorylation spleen tyrosine kinase (Syk) important OLL2712, which not triggered by a alone. Notably, activation Syk depend on macrophage-inducible C-type lectin (Mincle), one receptors. surface-expressed Mincle is responsible for OLL2712. Instead, it depends incorporation into tsDCs, suggesting recognizes incorporated intracellularly. summary, initially recognized TLR2, subsequently expression recognize ultimately inducing IMPORTANCE The objective study elucidate mechanism (OLL2712), previously identified our research group as potent stimulator interleukin-10 cells, exerts its immunomodulatory effects. Our findings indicate acts synergy pattern-recognition receptors: 2 Macrophage inducible (Mincle). Additionally, needs be internalized intracellularly Mincle. These represent insights detailed anti-inflammatory

Language: Английский

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Probiotic Potential of Lactic Acid Bacteria with Antioxidant Properties in Modulating Health: Mechanisms, Applications, and Future Directions

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106181 - 106181

Published: Feb. 1, 2025

Language: Английский

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