Nutrients,
Journal Year:
2025,
Volume and Issue:
17(7), P. 1165 - 1165
Published: March 27, 2025
Objectives:
This
systematically
scoping
review
aims
to
evaluate
the
therapeutic
potential
and
clinical
benefits
of
specific
Lactiplantibacillus
plantarum
(L.
plantarum)
strains
in
human
health,
identifying
their
strain-specific
effects
across
various
medical
conditions.
Methods:
Following
PRISMA
for
Scoping
Reviews
(PRISMA-ScR)
guidelines
employing
PICO
framework,
a
comprehensive
literature
search
was
conducted
PubMed
Embase
databases
identify
relevant
studies
published
up
December
2023.
Inclusion
criteria
were
rigorously
applied
ensure
selection
high-quality
focusing
on
application
distinct
L.
stains.
Results:
analyzed
several
unique
69
studies,
benefits.
299v
effectively
improved
gastrointestinal
symptoms,
enhanced
oral
reduced
systemic
inflammation.
IS-10506
exhibited
notable
immunomodulatory
effects,
especially
managing
atopic
dermatitis.
LB931
showed
promise
decreasing
pathogenic
colonization,
supporting
women's
vaginal
health.
Additionally,
CCFM8724
demonstrated
reducing
early
childhood
caries,
highlighting
its
pediatric
care.
Conclusions:
The
is
extensive,
with
certain
exhibiting
promising
health
concerns.
findings
this
advocate
integration
into
practice,
emphasizing
need
further
research
elucidate
mechanisms
action,
optimal
dosages,
long-term
safety
profiles.
Frontiers in Microbiology,
Journal Year:
2025,
Volume and Issue:
16
Published: March 26, 2025
Introduction
Hyperuricemia
(HUA)
is
characterized
by
metabolic
abnormalities
in
purine
metabolism,
leading
to
an
excessive
accumulation
of
uric
acid
the
bloodstream.
This
condition
not
only
prevalent
but
also
significantly
linked
exacerbation
various
chronic
diseases,
including
renal
impairment.
Notably,
asymptomatic
hyperuricemia
frequently
associated
with
inflammatory
responses
and
alterations
intestinal
microbiota.
Thus,
it
imperative
explore
effective
therapeutic
interventions
for
HUA
mitigate
its
health
risks.
Methods
The
present
study
aimed
elucidate
protective
effects
Plantaginis
Semen
polysaccharides
(PSP)
a
rat
model
induced
adenine
(AD)
potassium
oxonate
(PO)
gavage.
Over
treatment
period
five
weeks,
animals
received
either
PSP
or
allopurinol
(AL).
Comprehensive
assessments
were
performed,
blood
biochemistry
analysis,
histopathological
evaluation,
Western
blot
analyses
investigate
expression
levels
key
transport
proteins,
as
well
16S
rRNA
sequencing
microbiota
shifts.
Results
findings
demonstrated
that
decreased
serum
(UA)
alleviated
dysfunction
through
modulation
xanthine
oxidase
(XOD)
adenosine
deaminase
(ADA)
concentrations
transporters,
namely
glucose
transporter
protein
9
(GLUT9),
urate
1
(URAT1),
ATP-binding
cassette
superfamily
member
2
(ABCG2),
organic
anion
(OAT1).
Furthermore,
exhibited
notable
anti-inflammatory
properties,
reflected
reduced
pro-inflammatory
cytokines
such
tumor
necrosis
factor-α
(TNF-α)
interleukin-1β
(IL-1β).
Conclusion
In
summary,
substantiates
potential
treating
dual
action
lowering
imparting
effects.
observed
gut
further
supports
role
maintaining
homeostasis.
Future
investigations
should
focus
on
clinical
applicability
mechanisms
underlying
beneficial
impacts
disorders.
Nutrients,
Journal Year:
2025,
Volume and Issue:
17(7), P. 1165 - 1165
Published: March 27, 2025
Objectives:
This
systematically
scoping
review
aims
to
evaluate
the
therapeutic
potential
and
clinical
benefits
of
specific
Lactiplantibacillus
plantarum
(L.
plantarum)
strains
in
human
health,
identifying
their
strain-specific
effects
across
various
medical
conditions.
Methods:
Following
PRISMA
for
Scoping
Reviews
(PRISMA-ScR)
guidelines
employing
PICO
framework,
a
comprehensive
literature
search
was
conducted
PubMed
Embase
databases
identify
relevant
studies
published
up
December
2023.
Inclusion
criteria
were
rigorously
applied
ensure
selection
high-quality
focusing
on
application
distinct
L.
stains.
Results:
analyzed
several
unique
69
studies,
benefits.
299v
effectively
improved
gastrointestinal
symptoms,
enhanced
oral
reduced
systemic
inflammation.
IS-10506
exhibited
notable
immunomodulatory
effects,
especially
managing
atopic
dermatitis.
LB931
showed
promise
decreasing
pathogenic
colonization,
supporting
women's
vaginal
health.
Additionally,
CCFM8724
demonstrated
reducing
early
childhood
caries,
highlighting
its
pediatric
care.
Conclusions:
The
is
extensive,
with
certain
exhibiting
promising
health
concerns.
findings
this
advocate
integration
into
practice,
emphasizing
need
further
research
elucidate
mechanisms
action,
optimal
dosages,
long-term
safety
profiles.
