International Journal of Biosciences (IJB),
Journal Year:
2023,
Volume and Issue:
unknown
Published: Sept. 4, 2023
Obesity
has
severe
reproductive
implications
depending
on
the
amount
and
distribution
of
body
fat.Epidemiological
studies
have
shown
that
obesity
leads
to
abnormalities
in
menstruation,
infertility,
miscarriage,
poor
pregnancy
outcomes,
reduced
fetal
well-being,
diabetes
mellitus.No
previous
study
investigated
Prevalence
Its
Impact
Female
Reproductive
Health
Outcomes
Al-Baha
Region,
Saudi
Arabia
yet.We
retrospective
cross
sectional
case
series
various
patients
see
correlation
between
obesity,
metabolic
hormones,
female
disorders.Because
potential
benefits
weight
management,
lifestyle
intervention
programs
should
constitute
first-line
treatment
for
women
with
disorders.This
cross-sectional
included
adult
(aged
>10
years)
obesity-related
disorders.We
examined
all
patient
databases
contained
disorders
pharmacotherapy
prescribed
a
definite
diagnosis
abortion,
ectopic
pregnancy,
cervical
cancer,
irregular
other
less
commonly
reported
abnormalities.The
150
patients,
87.9%
being
married
12.1%
unmarried.Obesity
was
linked
infertility
concerns
36.6%
(n=55)
obese
adults,
followed
by
20.6%
(n=31)
menstrual
cycles.The
percentage
PCODs
associated
increasing
8.7%
(n=13).The
proportion
who
had
abortions
(n=13).Obesity
caused
cancer
small
number
(1.3%,
n=2).Other
complications
were
responsible
44%
cases.In
addition,
statistically
significant
difference
0.001
found
Variations
different
age
groups.A
0.05
regimens
based
groups.The
BMI
outcome
according
groups
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 15, 2024
Infertility
is
a
devastating
condition
affecting
one
in
six
people
globally.
In
many
cases,
the
underlying
causes
are
unknown.
Emerging
evidence
suggests
that
microbiota
influences
reproduction,
yet
mechanistic
link
between
microbiota,
ovarian
function,
and
length
of
fertile
lifespan
remain
unexplored.
Here
we
report
controls
reproductive
by
maintaining
primordial
follicle
pool,
process
mediated
microbiota-derived
short
chain
fatty
acids
modulating
gene
regulatory
networks
crucial
for
survival
reserve.
Dietary
perturbation
during
critical
developmental
window
sufficient
to
diminish
reserve,
reduce
oocyte
retrieval,
impair
preimplantation
embryo
viability,
mirroring
challenges
human
fertility
treatments.
Targeted
interventions
restore
improve
assisted
outcomes,
particularly
when
implemented
early.
These
findings
reveal
novel
contribution
host-microbe
interactions
mammalian
reproduction
demonstrate
impacts
function
fertility.
Cells,
Journal Year:
2024,
Volume and Issue:
13(18), P. 1592 - 1592
Published: Sept. 22, 2024
The
field
of
reproductive
biology
has
made
significant
progress
in
recent
years,
identifying
specific
molecular
players
that
influence
oocyte
development
and
function.
Among
them,
sirtuin
3
(SIRT3)
attracted
particular
attention
for
its
central
role
mediating
mitochondrial
function
cellular
stress
responses
oocytes.
So
far,
studies
have
demonstrated
the
knockdown
SIRT3
leads
to
a
decrease
blastocyst
formation
an
increase
oxidative
within
embryo,
underscoring
importance
maintaining
redox
balance
critical
embryonic
survival
growth.
Furthermore,
literature
reveals
signaling
pathways,
such
as
SIRT3-
Glycogen
synthase
kinase-3
beta
(GSK3β)
deacetylation
pathway,
crucial
mitigating
stress-related
anomalies
meiosis,
particularly
under
conditions
like
maternal
diabetes.
Overall,
emerging
regulating
highlights
understanding
intricate
connections
between
metabolism,
response
overall
health
This
knowledge
could
lead
novel
strategies
support
quality
fertility,
with
far-reaching
implications
assisted
technologies
women's
healthcare.
commentary
aims
provide
overview
oocytes
by
synthesizing
results
from
multitude
studies.
aim
is
elucidate
development,
maturation,
aging
identify
areas
where
further
research
needed.
Scientific Journal of Technology,
Journal Year:
2023,
Volume and Issue:
4(12), P. 1 - 6
Published: Jan. 3, 2023
To
investigate
the
effects
of
vine
tea
extract
(VTE)
on
high-fat-diet
(HFD)
induced
obesity
in
mice.
A
C57BL/6J
mouse
model
by
8-week
high-fat
diet
was
established.
By
measuring
activities
aspartate
aminotransferase
(AST)
and
alanine
(ALT)
contents
triglyceride
(TG),
total
cholesterol
(T-CHO),
low
density
lipoprotein
(LDL-C)
high
(HDL-C)
serum.
Pathological
changes
were
observed
H&E
staining
to
explore
effect
VTE
obese
The
results
showed
that,
compared
with
group,
levels
AST,
ALT,
TG,
T-CHO,
LDL-C
serum
significantly
decreased,
while
HDL-C
increased
dose
groups.
It
also
improved
fat
vacuoles,
inflammatory
infiltration,
response
liver
tissue.
In
conclusion,
may
improve
lipid
metabolism
HFD-induced
mice
inhibiting
oxidative
stress
response.
International Journal of Biosciences (IJB),
Journal Year:
2023,
Volume and Issue:
unknown
Published: Sept. 4, 2023
Obesity
has
severe
reproductive
implications
depending
on
the
amount
and
distribution
of
body
fat.Epidemiological
studies
have
shown
that
obesity
leads
to
abnormalities
in
menstruation,
infertility,
miscarriage,
poor
pregnancy
outcomes,
reduced
fetal
well-being,
diabetes
mellitus.No
previous
study
investigated
Prevalence
Its
Impact
Female
Reproductive
Health
Outcomes
Al-Baha
Region,
Saudi
Arabia
yet.We
retrospective
cross
sectional
case
series
various
patients
see
correlation
between
obesity,
metabolic
hormones,
female
disorders.Because
potential
benefits
weight
management,
lifestyle
intervention
programs
should
constitute
first-line
treatment
for
women
with
disorders.This
cross-sectional
included
adult
(aged
>10
years)
obesity-related
disorders.We
examined
all
patient
databases
contained
disorders
pharmacotherapy
prescribed
a
definite
diagnosis
abortion,
ectopic
pregnancy,
cervical
cancer,
irregular
other
less
commonly
reported
abnormalities.The
150
patients,
87.9%
being
married
12.1%
unmarried.Obesity
was
linked
infertility
concerns
36.6%
(n=55)
obese
adults,
followed
by
20.6%
(n=31)
menstrual
cycles.The
percentage
PCODs
associated
increasing
8.7%
(n=13).The
proportion
who
had
abortions
(n=13).Obesity
caused
cancer
small
number
(1.3%,
n=2).Other
complications
were
responsible
44%
cases.In
addition,
statistically
significant
difference
0.001
found
Variations
different
age
groups.A
0.05
regimens
based
groups.The
BMI
outcome
according
groups
