Approach the Patient With Obstructive Sleep Apnea and Obesity

The Journal of Clinical Endocrinology & Metabolism, Journal Year: 2023, Volume and Issue: 109(3), P. e1267 - e1279

Published: Sept. 27, 2023

Abstract Obstructive sleep apnea (OSA) and obesity are highly prevalent bidirectionally associated. OSA is underrecognized, however, particularly in women. By mechanisms that overlap with those of obesity, increases the risk developing, or having poor outcomes from, comorbid chronic disorders impairs quality life. Using 2 illustrative cases, we discuss relationships between type diabetes, dyslipidemia, cardiovascular disease, cognitive disturbance, mood disorders, lower urinary tract symptoms, sexual function, reproductive disorders. The differences men women, phenotypic variability OSA, highlighted. When probability high due to consistent comorbidities, both, a diagnostic study advisable. Continuous positive airway pressure mandibular advancement splints improve symptoms. Benefits for comorbidities variable depending on nightly duration use. contrast, weight loss optimization lifestyle behaviors consistently beneficial.

Language: Английский

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The impact of continuous positive airway pressure therapy on cardiovascular events in patients with obstructive sleep apnoea: an updated systematic review and meta-analysis

Sleep And Breathing, Journal Year: 2024, Volume and Issue: 28(5), P. 2095 - 2105

Published: July 31, 2024

Language: Английский

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The possible effect of anti-diabetic agents GLP-1RA and SGLT-2i on the respiratory system function

Endocrine, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 17, 2024

Language: Английский

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Radiofrequency Coblation Inferior Turbinoplasty with Modified UPPP for the Treatment of Obstructive Sleep Apnea-Hypopnea Syndrome

Ear Nose & Throat Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Objective: To compare the efficacy of surgical treatment in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) involving a standalone modified uvulopalatopharyngoplasty (mUPPP) and radiofrequency coblation inferior turbinoplasty mUPPP. Methods: In this study, retrospective analysis 79 OSAHS turbinate hypertrophy oropharyngeal obstruction undergoing was performed. According to different methods, were divided into 2 groups (Group A Group B). included 36 treated B 43 mUPPP bilateral turbinoplasty. Polysomnography (PSG), active anterior rhinomanometry, success rate, complication used assess groups. The successful result defined as 50% or greater decrease index (AHI) postoperative PSG. Results: Before surgery, there no significant differences age, gender, neck circumference, body mass index, Friedman tongue position grade, tonsil size Epworth sleepiness scale score, total nasal resistance (TNR), AHI lowest O saturation (LSaO ) between After 6 months follow-up visits, AHI, LSaO , TNR showed improvement compared A. rate 76.74% 52.78% ( P = .025). There difference (13.89% vs 23.26%, .290). Conclusion: For obstruction, appears be more effective method than alone.

Language: Английский

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Comorbidities that modulate temporal risk for incident hypertension among patients with obstructive sleep apnea

Clinical Hypertension, Journal Year: 2025, Volume and Issue: 31(1)

Published: Jan. 1, 2025

Our study investigates the temporality of factors that modulate risk for developing hypertension (HTN) among patients with obstructive sleep apnea (OSA) without preexisting HTN at baseline. cohort consisted OSA cases (based on International Classification Diseases, 9th/10th Revision) 20 common comorbidities selected using a previously validated electronic health record (EHR)-based algorithm. We constructed survival model to estimate time-to-first diagnosis (among HTN). included those along sex, body mass index, race, and age. also performed validation date identified from our algorithm by utilizing chart reviews in 400 randomly chosen EHR-defined cases. Among 53,035 diagnosed between 2012 2021, 31,741 (59.8%) were thus met inclusion criteria. Within cohort, 15,830 (50.1%) did not develop HTN. Cardiovascular conditions (including atrial fibrillation, coronary atherosclerosis, hypercholesterolemia, diabetes), tobacco use, anemia, osteoarthrosis, gastroesophageal reflux disease observed increase incident Allergic rhinitis, fatigue, joint pain, vitamin D deficiency Chart review demonstrated diagnoses documented notes median 38 days 738 days, respectively, prior being coded EHR. In large EHR sample, we are associated increased OSA. These findings may help guide counseling efforts newly regarding

Language: Английский

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Periodontal Disease and Obstructive Sleep Apnea: Shared Mechanisms, Clinical Implications, and Future Research Directions

Applied Sciences, Journal Year: 2025, Volume and Issue: 15(2), P. 542 - 542

Published: Jan. 8, 2025

This review explores the emerging relationship between obstructive sleep apnea (OSA) and periodontal disease (PD), emphasizing shared inflammatory pathways, overlapping risk factors, potential systemic health implications. Both conditions are characterized by chronic inflammation oxidative stress, which independently contribute to cardiovascular disease, diabetes, other disorders. Evidence suggests a bidirectional relationship, with OSA-related hypoxia exacerbating tissue breakdown PD-induced potentially influencing OSA severity. However, causative nature of PD remains uncertain, largely due inconsistencies in diagnostic criteria, methodological variability, study heterogeneity. highlights essential role systematic reviews (SRs) synthesizing current evidence, identifying research gaps, guiding future studies. To maximize their impact, SRs should adhere rigorous quality standards, improve transparency data reporting, address heterogeneity included Future focus on longitudinal interventional designs, standardize protocols, investigate biomarkers, oral microbiome profiles, mediators elucidate mechanisms linking PD. Multidisciplinary collaboration dental specialists is crucial advancing evidence-based strategies that patient outcomes broader implications these often coexisting conditions.

Language: Английский

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Prediabetes and sleep patterns: Linking poor sleep to adverse outcomes through metabolic syndrome

Diabetes Research and Clinical Practice, Journal Year: 2025, Volume and Issue: 221, P. 112044 - 112044

Published: Feb. 14, 2025

Language: Английский

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Clinically available predictors of obstructive sleep apnoea requiring treatment in type 2 diabetes patients in primary care

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 13, 2025

Obstructive sleep apnoea is a common yet frequently underdiagnosed condition in patients with type 2 diabetes, particularly primary care. Early detection important, as untreated may contribute to worsened metabolic control and increased cardiovascular risk. This study evaluated 164 diabetes found that 75% had obstructive apnoea, 31% requiring treatment for moderate severe cases. Predicting which medical indicated (i.e., OSA) proved challenging, typical clinical symptoms most other readily available parameters be unreliable indicators. However, central fat distribution, by higher waist-to-hip ratio (odds 3.31, 95% confidence interval 1.91–6.25, p = 0.0032), the presence of albuminuria 7.46, 1.99–27.89, 0.0244), emerged significant predictors, representing novel finding. Screening tools such STOP-Bang questionnaire limited predictive accuracy. These findings highlight importance targeted screening those distribution or albuminuria, reduce underdiagnosis potentially improve outcomes.

Language: Английский

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The use of statins are associated with an increased risk of new-onset diabetes in patients with hypertension and obstructive sleep apnoea, a longitudinal study

Diabetology & Metabolic Syndrome, Journal Year: 2025, Volume and Issue: 17(1)

Published: April 9, 2025

Statins, a kind of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, are first-line cholesterol-lowering drugs that widely used in the primary and secondary prevention coronary atherosclerotic heart disease (CAD). However, safety statins has been spotlight as recent studies have shown may increase incidence diabetes. Therefore, we conducted study use new-onset diabetes(NODM) people with hypertension obstructive sleep apnea (OSA) to better understand relationship provide guidance for future clinical management. We retrospective cohort using data from Urumchi Hypertension Database (UHDATA), including patients aged ≥ 18 years diagnosed apnoea treated at our Centre between 2015 2019. The was followed until November 2023 endpoint new onset diabetes during follow-up period. hazard ratio (HR) 95% confidence interval (CI) were calculated Cox proportional hazards model. Sensitivity analyses performed by excluding those pre-diabetes baseline. 8755 OSA, 80.1% up. During median 31 months, 740 developed NODM. NODM per 1000 person-years 53.1. In regression analysis, risk is significantly higher who continue take (HR = 1.77, CI, 1.34-2.34, P < 0.001), results remain significant sensitive analysis. OSA hypertension, continuous increases physicians should be vigilant about monitoring blood glucose levels when this patients.

Language: Английский

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Association Between Obstructive Sleep Apnea and Regional Fat: A Cross-Sectional Analysis of National Health and Nutrition Examination Survey 2015–2018

Metabolic Syndrome and Related Disorders, Journal Year: 2025, Volume and Issue: unknown

Published: May 19, 2025

Purpose: The relationship between regional fat and obstructive sleep apnea (OSA) remains poorly understood. This study seeks to explore the link OSA, utilizing data from National Health Nutrition Examination Survey (NHANES). Methods: cross-sectional analysis used NHANES 2015-2018 data. OSA symptoms were assessed through questionnaires. Regional mass (FM) was measured using dual-energy X-ray absorptiometry, including trunk, arm, leg, android, gynoid, abdominal FM. index (FMI) calculated by dividing FM square of height. Logistic regression evaluated association FMI with univariate stratified analyses identify potential effect modifiers. Results: A total 3,099 participants included, 1,595 classified into group. Significant associations found several FMIs, abdomen. These consistent in males, females, leg gynoid not linked OSA. Stratified race revealed significant indices (trunk, FMI) non-Hispanic Whites other Hispanics. No observed Mexican American or Black groups. Stratification body (BMI) indicated distinct profiles: obese individuals (BMI ≥30) showed limited while nonobese <30) displayed broader encompassing all FMIs. Both highlighted as strongest predictor Conclusion: Higher FMI, particularly fat, is associated an increased risk stronger male, White, populations.

Language: Английский

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