Epigallocatechin Gallate for the Treatment of Benign and Malignant Gynecological Diseases—Focus on Epigenetic Mechanisms

Nutrients, Journal Year: 2024, Volume and Issue: 16(4), P. 559 - 559

Published: Feb. 17, 2024

The most common malignant gynecologic diseases are cervical, uterine, ovarian, vaginal, and vulvar cancer. Among them, ovarian cancer causes more deaths than any other of the female reproductive system. A great number women suffer from endometriosis, uterine fibroids (UFs), adenomyosis, dysmenorrhea, polycystic ovary syndrome (PCOS), which widespread benign health problems causing troublesome painful symptoms significantly impairing quality life affected women, they some main infertility. In addition to available surgical pharmacological options, effects supporting standard treatment with naturally occurring compounds, mainly polyphenols, being studied. Catechins responsible for majority potential benefits attributed green tea consumption. Epigallocatechin gallate (EGCG) is considered a non-toxic, natural compound anticancer properties. Antioxidant action its function, but attention also drawn participation in cell division inhibition, apoptosis stimulation epigenetic regulation. this narrative review, we describe role EGCG consumption preventing development disorders such as UF, PCOS, well conditions. We discuss possible mechanisms that may be related EGCG.

Language: Английский

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Revolutionizing Cosmetic Ingredients: Harnessing the Power of Antioxidants, Probiotics, Plant Extracts, and Peptides in Personal and Skin Care Products

Cosmetics, Journal Year: 2024, Volume and Issue: 11(5), P. 157 - 157

Published: Sept. 12, 2024

The burgeoning interest in natural components personal care products has led to significant research and development of ingredients such as plant extracts, antioxidants, peptides, probiotics. These have been recognized for their potential enhance skin health through various mechanisms, addressing consumer demand that are both effective benign. Plant known rich composition bioactive compounds, offer a myriad benefits including antioxidant, anti-inflammatory, antimicrobial properties, making them invaluable formulations. Antioxidants, derived from plants other sources, play pivotal role protecting the oxidative damage, thereby preventing premature aging promoting vitality. Bioactive peptides garnered attention owing multifunctional activities include collagen synthesis, inhibiting enzymes responsible degradation, reducing inflammation, contributing regeneration anti-aging. Probiotics expanded utility beyond gut care, where they help maintaining microbiome balance, thus enhancing barrier function potentially mitigating disorders. purpose this review is explore individual roles probiotics products, while emphasizing synergistic effects when combined. By integrating these components, paper aims highlight developing innovative skincare formulations not only address specific concerns but also contribute overall health, aligning with increasing preference holistic solutions.

Language: Английский

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The Association between Dietary Nutrient Intake and Acceleration of Aging: Evidence from NHANES

Nutrients, Journal Year: 2024, Volume and Issue: 16(11), P. 1635 - 1635

Published: May 27, 2024

The acceleration of aging is a risk factor for numerous diseases, and diet has been identified as an especially effective anti-aging method. Currently, research on the relationship between dietary nutrient intake accelerated remains limited, with existing studies focusing small number individual nutrients. Comprehensive single mixed effects nutrients not conducted. This study aimed to comprehensively explore intakes, both singly in combination, aging. Data this were extracted from 2015–2018 National Health Nutrition Examination Surveys (NHANES). was measured by phenotypic age acceleration. Linear regression (linear), restricted cubic spline (RCS) (nonlinear), weighted quantile sum (WQS) (mixed effect) models used association A total 4692 participants aged ≥ 20 included study. In fully adjusted models, intakes 16 negatively associated (protein, vitamin E, A, beta-carotene, B1, B2, B6, K, phosphorus, magnesium, iron, zinc, copper, potassium, fiber, alcohol). Intakes sugars, C, caffeine, alcohol showed significant nonlinear associations Additionally, Single well may mitigate Moderately increasing specific maintaining balance be key strategies prevent

Language: Английский

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The Preventive Role of the Vitamin D Endocrine System in Cervical Cancer

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(10), P. 8665 - 8665

Published: May 12, 2023

Vitamin D along with its active metabolite calcitriol and metabolic signaling system, known as the vitamin endocrine have been widely recognized a pivotal regulator of calcium homeostasis in addition to non-calcemic antitumoral effects variety human cancers, including cervical cancer. Several studies found an inverse relationship between incidence neoplasia levels. This narrative review updates current evidence supporting notion that system has preventive role on cancer, mainly early phases disease, acting at level suppressing cell proliferation, promoting apoptosis, modulating inflammatory responses, probably favoring clearance papillomavirus-dependent lesions. Although optimal status helps prevention regression low-grade squamous intraepithelial lesions cervix, it appears alone or combined chemotherapeutic agents little effectivity once advanced cancer is established. These observations suggest might exert beneficial actions by preventing onset progression.

Language: Английский

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Evaluation of the Main Macro-, Micro- and Trace Elements Found in Fallopia japonica Plants and Their Traceability in Its Honey: A Case Study from the Northwestern and Western Part of Romania

Plants, Journal Year: 2024, Volume and Issue: 13(3), P. 428 - 428

Published: Jan. 31, 2024

Fallopia japonica (Japanese knotweed, Reynoutria or Polygonum cuspidatum) is considered an extremely invasive plant worldwide and a bioindicator of heavy metals. Yet, its potential as crop for honeybees still underevaluated. This study employs atomic absorption spectrometry to quantitatively analyze the concentration macro-elements, namely, calcium (Ca), potassium (K) magnesium (Mg); micro-elements, such copper (Cu), iron (Fe), manganese (Mn) selenium (Se); trace elements, i.e., cadmium (Cd), chromium (Cr), nickel (Ni) lead (Pb) in different anatomic parts (FJ) plants (roots, rhizomes, stems, leaves) their traceability into honey. research encompasses thorough examination samples collected from northwestern western part Romania, providing insights elemental composition. The results showed that level elements decreases terms honey (Pb was not detected any analyzed samples, while Cd had minimum content 0.001 mg/kg), ensuring quality health safety consumption. Moreover, data generated can function valuable resource explore plant’s positive eco-friendly impacts, particularly relation

Language: Английский

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Characterization of carotenoid profiles and presence of functional markers in sub-tropical maize (Zea mays L.) inbred lines

Czech Journal of Genetics and Plant Breeding, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 28, 2025

Language: Английский

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Investigating causal relationships between coffee consumption and gynecological diseases: a Mendelian randomization study

Archives of Medical Science, Journal Year: 2025, Volume and Issue: unknown

Published: March 5, 2025

Introduction Gynecological diseases, including infections, endocrine disorders, and tumors, significantly impact women’s quality of life. Emerging evidence suggests that metabolic factors, nutrition, dietary habits, such as coffee consumption, may influence these conditions. This study employed two-sample Mendelian randomization (2SMR) to investigate the relationship between intake gynecological diseases. Material methods Publicly available genome-wide association (GWAS) data from Integrative Epidemiology Unit (IEU) GWAS database were analyzed using TwoSampleMR R package. Data on consumption extracted UK Biobank. Instrumental variables selected based p < 5 × 10–8 F-statistic > 10, causal relationships assessed inverse variance weighting (IVW) Wald ratio (WR) method. Heterogeneity pleiotropy tested MR-Egger regression. A negative control analysis skin color was performed address confounding by population stratification. Results The 2SMR identified significant associations reduced risks ovarian cancer (OR = 0.07, 95% CI: 0.01–0.84), cyst 0.68, 0.49–0.95), endometriosis 0.99, 0.99–1.00). Conversely, increased noted for endometrioid 7.88, 1.05–59.22). Analysis different types revealed ground associated with decreased endometriosis, while decaffeinated showed positive endometriosis. Conclusions Coffee intake, especially coffee, lower risk certain However, increase risks. Further research is needed understand mechanisms behind findings.

Language: Английский

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A Narrative Review of Quercetin’s Role as a Bioactive Compound in Female Reproductive Disorders

Nutrients, Journal Year: 2025, Volume and Issue: 17(7), P. 1118 - 1118

Published: March 24, 2025

Lifestyle, nutrition, and metabolic status are central to maintaining women's reproductive health. With the rising prevalence of infertility, need for effective strategies preserve enhance well-being has become increasingly urgent. Quercetin, a plant-derived polyphenol, attracted growing interest its potential support health, regulate hormonal balance, improve fertility. This narrative review examines Quercetin's role in health delineates possible mechanisms action female system disorders, including polycystic ovary syndrome, recurrent miscarriage, cervical, ovarian, endometrial cancer (EC). By highlighting biological pathways through which quercetin may exert effects, this article underscores further research clinical trials validate therapeutic applications as bioactive compound foods aimed at enhancing

Language: Английский

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Multifunctional DNA nano-sponge system for targeted sensitization of ovarian cancer chemotherapy via metabolic reprogramming and ferroptosis induction

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: unknown, P. 113663 - 113663

Published: March 1, 2025

Language: Английский

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Dietary nutrient intake and cancer presence: evidence from a cross-sectional study

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: April 1, 2025

Background While the role of specific nutrients in cancer is established, associations between comprehensive dietary nutrient intake and presence remain underexplored. This cross-sectional study investigates global profiles relation to solid blood cancers. Methods A total 42,732 mobile adults from National Health Nutrition Examination Survey (NHANES, 2001–2023) were enrolled this study. The potential intakes 34 4 common trace components with investigated by weighted logistic regression restricted cubic spline. Results Higher saturated fatty acid (OR = 1.1082, 95% CI: 1.0110–1.2146), β -carotene 1.0431, 1.0096–1.0777) vitamin K 1.0370, 1.0094–1.0654) was positively associated overall presence, while phosphorus 0.9016, 0.8218–0.9892) showed a protective association. For tumors, 1.1099), α 1.0353), 1.0484), 1.0405) exhibited positive associations. Retinol linked carcinoma 1.0935, 1.0222–1.1698). Dose–response analyses revealed linear relationships without non-linear thresholds. Conclusion Specific nutrients, notably fats, carotenoids, K, are increased whereas reduced presence. Due nature measurement after diagnosis, causal relationship could not be established. These findings underscore need for longitudinal studies establish causality inform interventions management.

Language: Английский

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