The Metabolic Syndrome, a Human Disease

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(4), P. 2251 - 2251

Published: Feb. 13, 2024

This review focuses on the question of metabolic syndrome (MS) being a complex, but essentially monophyletic, galaxy associated diseases/disorders, or just related rather independent pathologies. The human nature MS (its exceptionality in Nature and its close interdependence with action evolution) is presented discussed. text also describes components, special emphasis description their interrelations (including syndromic development recruitment), as well consequences upon energy handling partition. main theories MS’s origin are relation to hepatic steatosis, type 2 diabetes, obesity, encompass most components described so far. differential effects sex biological considered under light social needs evolution, which directly epidemiology, severity, relations senescence. triggering maintenance factors discussed, especial inflammation, complex process affecting different levels organization critical element for development. Inflammation operation connective tissue adipose organ) widely studied acknowledged influence diet. role diet composition, including transcendence anaplerotic Krebs cycle from dietary amino acid supply (and timing), developed context testosterone β-estradiol control insulin-glycaemia core system carbohydrate-triacylglycerol handling. high probability acting unique (essentially monophyletic) presented, together additional perspectives/considerations treatment this ‘very’ disease.

Language: Английский

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Ultraprocessed foods and chronic kidney disease—double trouble

Clinical Kidney Journal, Journal Year: 2023, Volume and Issue: 16(11), P. 1723 - 1736

Published: May 4, 2023

ABSTRACT High energy intake combined with low physical activity generates positive balance, which, when maintained, favours obesity, a highly prevalent morbidity linked to development of non-communicable chronic diseases, including kidney disease (CKD). Among many factors contributing disproportionately high intakes, and thereby the obesity epidemic, type degree food processing play an important role. Ultraprocessed foods (UPFs) are industrialized quite often high-energy-dense products added sugar, salt, unhealthy fats additives formulated be palatable or hyperpalatable. UPFs can trigger addictive eating behaviour is typically characterized by increase in intake. Furthermore, consumption UPFs, hallmark Western diet, results diets poor quality. A UPF associated higher risk for CKD. In addition, patients CKD likely predispose and/or exacerbate uraemic metabolic derangements, such as insulin resistance, acidosis, hypertension, dysbiosis, hyperkalaemia hyperphosphatemia. Global sales per capita increased all continents recent decades. This factor responsible nutrition transition, home-made meals being replaced ready-to-eat products. this review we discuss potential activating hedonic their main implications health, especially health complications We also present various aspects consequences on planetary future directions research bring awareness harms within scenario.

Language: Английский

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Maternal consumption of nut oil (Bertholletia excelsa): Evidence of anxiolytic-like behavior and reduction in brain lipid peroxidation on the progeny of rats

Brain Research, Journal Year: 2025, Volume and Issue: 1851, P. 149501 - 149501

Published: Feb. 6, 2025

Language: Английский

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Unbalanced Diets: High-Fat, High-Sucrose and High-Protein Diets

Nutrients, Journal Year: 2025, Volume and Issue: 17(4), P. 655 - 655

Published: Feb. 12, 2025

This Special Issue of Nutrients, “Unbalanced Diets: High-Fat, High-Sucrose and High-Protein Diets” includes five original articles conducted in animal models [...]

Language: Английский

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Future of Nutraceuticals as a Safe and Intelligent Food

Published: Jan. 1, 2025

Language: Английский

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Polyphenol Bioaccessibility and Antioxidant Activity of Pomegranate (Punica granatum) Peel Supplementation in Diet-Induced Obese Rats

Journal of Medicinal Food, Journal Year: 2023, Volume and Issue: 26(8), P. 570 - 579

Published: July 27, 2023

Fruit by-products are a source of biocompounds with antioxidant properties and potential role in the obesity treatment. This study aimed to assess effect pomegranate (Punica granatum) peel (PP) supplementation on total capacity (TAC) diet-induced obese rats. Thus, an vitro gastrointestinal digestion was performed evaluate phenolic content (TPC) PP. Moreover, 15 male Wistar rats were randomized into three groups: control diet (CTL; 3.35 kcal/g), cafeteria (CAF) (3.72 CAF supplemented PP (CAF + PP; 200 mg/kg body weight; 3.72 kcal/g). Serum TAC analyzed by ferric reducing power 2,2-Diphenil-1-picrylhydrazil assay. TPC accounted for 8.82 ± 0.14 mg GAE/g undigested samples. However, process decreased 94% bioaccessibility compounds intestinal phase, while increased serum Therefore, although diminished after process, found

Language: Английский

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Intermittent Fasting Improves Social Interaction and Decreases Inflammatory Markers in Cortex and Hippocampus

Molecular Neurobiology, Journal Year: 2024, Volume and Issue: unknown

Published: July 13, 2024

Language: Английский

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Novel insights and mechanisms of diet-induced obesity: Mid-term versus long-term effects on hepatic transcriptome and antioxidant capacity in Sprague-Dawley rats

Life Sciences, Journal Year: 2023, Volume and Issue: 324, P. 121746 - 121746

Published: April 29, 2023

The study of molecular mechanisms related to obesity and associated pathologies like type 2-diabetes non-alcoholic fatty liver disease requires animal experimental models in which the obesogenic diet length period induce deeply affect metabolic alterations. Therefore, this aimed test influence aging along a rat model diet-induced gene expression hepatic transcriptome. A high-fat/high-fructose was used. Mid- (13 weeks) long-term (21 periods were established. Caloric intake, bodyweight, fat, acid profile, histological changes, antioxidant activity, complete transcriptome analyzed. Excess steatosis altered lipid histology, modifications dysregulated transcripts cell structure, glucose & metabolism, detoxifying capacity found. Modifications obese control rats accounted for by different lengths studied. Main fat accumulation de novo lipogenesis or catabolism mid- study, respectively. choice obesity-induction is key factor used as each specific design.

Language: Английский

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Maternal High-Fat Diet Controls Offspring Kidney Health and Disease

Nutrients, Journal Year: 2023, Volume and Issue: 15(12), P. 2698 - 2698

Published: June 9, 2023

A balanced diet during gestation is critical for fetal development, and excessive intake of saturated fats lactation related to an increased risk offspring kidney disease. Emerging evidence indicates that a maternal high-fat influences health disease the via so-called renal programming. This review summarizes preclinical research documenting connection between disease, as well molecular mechanisms behind programming, early-life interventions offset adverse programming processes. Animal models indicate can be improved perinatal polyunsaturated fatty acid supplementation, gut microbiota changes, modulation nutrient-sensing signals. These findings reinforce significance offspring.

Language: Английский

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Maternal cafeteria diet programs fecal microbiota and modulates serum fatty acid and amino acid levels in adulthood rats.

Food Bioscience, Journal Year: 2024, Volume and Issue: 61, P. 104920 - 104920

Published: Aug. 13, 2024

Language: Английский

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