The Anti-Inflammatory Roles of Vitamin D for Improving Human Health

Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(12), P. 13514 - 13525

Published: Nov. 26, 2024

Vitamin D receptors (VDRs) are present in almost all cells of the immune system, including B cells, T NK (Natural Killer) dendritic and monocytes, as well epithelial many organs such intestine, pancreas, prostate, lungs, cardiomyocytes. In addition, some macrophages, can synthesize calcitriol by expressing 1α-hydroxylase. Upon binding to VDRs, vitamin (Vit D) regulates expression genes involved responses, those encoding for cytokines. It modulates production pro-inflammatory cytokines while promoting synthesis anti-inflammatory Vit also affects differentiation maturation system. By inhibiting nuclear factor kappa (NF-κB) mitogen-activated protein kinase (MAPK) pathways, reduces genes. These effects highlight potential a therapeutic agent management inflammatory diseases, autoimmune disorders, cardiovascular diabetes, metabolic syndrome, cancer, neurological depression, bowel disease.

Language: Английский

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Vitamin D and exercise improve VEGF-B production and IGF-1 levels in diabetic rats: insights the role of miR-1 suppression

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 8, 2025

Type 2 Diabetes Mellitus (T2DM) is closely associated with the development of vascular damage in heart. In this study, researchers aimed to determine whether Aerobic Training (AT) and Vitamin D supplementation (Vit D) could alleviate heart complications caused by diabetes. The effects an eight-week AT program Vit on expression miR-1, IGF-1 genes, VEGF-B cardiomyocytes rats T2DM. This study was experimental investigation. Fifty male Wistar were divided into groups Non-Diabetic Obese Control (NC; n = 10), diabetic (n 40). then randomly four groups: plus (AT + D; n-=10), Diabetic (C; 10). exercise underwent treadmill training for 8 weeks at aerobic intensity equal 50–60% their maximal oxygen uptake (VO2max), which corresponded a speed 15–25 m/min 0% incline, 30–60 min per day, 5 days week. received 5,000 international units (IU) (combined sesame oil) week via single-dose injection. Data analyzed using one-way analysis variance (ANOVA) followed Tukey's post-hoc test multiple comparisons among groups. Paired data paired t-tests. results showed that BW, BMI, FI significantly decreased (p 0.001 all variables), variables) compared baseline. contrast, increased C 0.001, p 0.006, 0.020, respectively) NC Significant differences observed between terms visceral fat, insulin, glucose, HOMA-IR variables). Serum 25-hydroxyvitamin levels varied 0.002). group both comparisons), upregulated downregulated miR-1 comparisons) groups, respectively. T2DM while decreasing miR-1. These more pronounced when combined. concludes combination has cardio-protective rats, counteracting abnormal angiogenesis induced are mediated, least part, upregulation VEGF-B, downregulation

Language: Английский

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Combined 25-hydroxyvitamin D concentrations and physical activity on mortality in US stroke survivors: findings from the NHANES

Nutrition Journal, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 13, 2025

25-hydroxyvitamin D [25(OH)D] concentrations and physical activity (PA) are linked both associated with changes in mortality. We examined the association of 25(OH)D PA all-cause or cause-specific mortality risk stroke survivors. The analysis included 677 survivors from National Health Nutrition Examination Survey (NHANES) 2007–2008 to 2017–2018. Independent joint associations 25(OH)D, among were analyzed using weighted Cox regression. identified 133 deaths [major adverse cardiovascular events (MACE), 34; non-MACE, 79] a median follow-up 5.8 years (interquartile, 2.8–8.9 years). In range adjusted models, high was observed lower compared low (HR, 0.376; 95% CI, 0.233–0.607) non-MACE 0.265; 0.143–0.490) consistently associated. At same time, no PA, 0.280; 95%CI, 0.107–0.733) 0.266; 0.087–0.810) death. addition, pooled analyses showed that had lowest death 0.132; 0.038–0.460) 0.092; 0.023–0.363), there is an additive interaction between non-MACE. conclusion, this study found combining levels enhanced protective effect which demonstrated synergistic them reducing These findings provide new ideas possibilities for prevention treatment cerebrovascular diseases, offering reference development clinical practice guidelines future.

Language: Английский

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The Role of Vitamin D in Reducing the Risk of Metabolic Disturbances That Cause Cardiovascular Diseases

Journal of Cardiovascular Development and Disease, Journal Year: 2023, Volume and Issue: 10(5), P. 209 - 209

Published: May 11, 2023

Among the most common problems facing public health today is a lack of vitamin D, which plays role in physiological processes chronic illness conditions. Vitamin D deficiency metabolic disorders has primary effects on osteoporosis, obesity, hypertension, diabetes, and cardiovascular disease (CVD). acts as “co-hormone” various tissues body, it been found that receptors (VDR) are present all cell types, suggesting wide range cells. Recently, there surge interest assessing its roles. insufficiency increases risk diabetes because lowers insulin sensitivity, also raises obesity CVD effect body’s lipid profile, particularly terms prevalence dangerously high levels low-density lipoproteins (LDL). Furthermore, often related to connected factors, highlighting need know D’s functions relation syndrome processes. Through looking at previous studies, this paper explains why important, how factors for through different mechanisms, affects CVD.

Language: Английский

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The Effectiveness of Supplementation with Key Vitamins, Minerals, Antioxidants and Specific Nutritional Supplements in COPD—A Review

Nutrients, Journal Year: 2023, Volume and Issue: 15(12), P. 2741 - 2741

Published: June 14, 2023

Currently, an increasing amount of evidence supports the notion that vitamins C, D and E, carotenoids, omega-3 fatty acids may protect against progression chronic respiratory diseases. Although obstructive pulmonary disease (COPD) primarily affects lung, it is often accompanied by extrapulmonary manifestations such as weight loss malnutrition, skeletal muscle dysfunction, excess harmful oxidants, which can lead to a decline in quality life possible death. Recently, role various vitamins, minerals, antioxidants mitigating effects environmental pollution smoking has received significant attention. Therefore, this review evaluates most relevant up-to-date on topic. We conducted literature between 15 May 2018 2023, using electronic database PubMed. Our search keywords included COPD, disease, FEV1, supplementation: vitamin A, D, B, omega-3, antioxidants, specific nutrient supplementations, clinical trials, randomized controlled trials (RCTs). focused studies measured serum levels these are more objective measure than patient self-reports. findings suggest appropriate dietary supplements needs be reconsidered for individuals who predisposed or at risk conditions.

Language: Английский

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Seasonal Variations in 25-Hydroxyvitamin D Levels among Pediatric Patients Attending the Healthcare Centre

Nutrients, Journal Year: 2024, Volume and Issue: 16(3), P. 379 - 379

Published: Jan. 27, 2024

Vitamin D plays an essential role in maintaining bone density, building the immune system, and regulating cell growth alongside other key biological functions. Limited data are available about seasonal variation vitamin levels pediatric population Saudi Arabia. This study aimed to investigate influence on circulating of 25(OH)D. A total 1790 outpatients who visited University healthcare centre were included this study. Overall, there was a noticeably high prevalence (69%) both combined 25(OH)D deficiency insufficiency. The highest mean serum concentration recorded summer (29 ng/mL) autumn (27 ng/mL). deficient insufficient categories predominant, accounting for 33% 36%, respectively. Comparable patterns during autumn, winter, spring. Interestingly, level significantly associated with four seasons (p = 0.001), females having higher spring than males. Furthermore, only we found significant association between gender status < 0.001 both). Another nationality winter p 0.01), In all seasons, age had negative impact (OH)D levels. However, relationship statistically 0.05) summer, winter. Gender predictor, odds ratio 1.67 2 indicating that being men positive There highly differences concentrations among different categories. experiences low D, particularly periods. showed seasonality, category, nationality, status, suggesting need tailored intervention monitoring reach adequate D. Healthcare practitioners policymakers may consider interplay age, gender, variations when addressing targeted supplementation approach high-risk groups develop health issues.

Language: Английский

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The Possible Role of Food and Diet in the Quality of Life in Patients with COPD—A State-of-the-Art Review

Nutrients, Journal Year: 2023, Volume and Issue: 15(18), P. 3902 - 3902

Published: Sept. 7, 2023

Diet has been described as a modifiable risk factor for the development and progression of chronic diseases, emerging evidence increasingly points to its preventive therapeutic role in obstructive pulmonary disease (COPD). While relationship between underlying diet is natural conditions such metabolic disorders, obesity, diabetes, etc., direct effect not so evident disease. Poor quality nutrient deficiencies respiratory including COPD, can be associated with disease-specific factors exacerbation symptoms. These symptoms improved by dietary interventions, leading positive changes pathogenesis life patients. Therefore, our aim was review latest randomized controlled trials (RCTs) interventions patients describe their effects on function, physical activity, systemic inflammatory parameters, life. We conducted literature search COPD PubMed, ClinicalTrials.gov, Cochrane Central Register Controlled Trials (CENTRAL) databases, focusing publications from 1 July 2018 2023. used specific keywords MESH terms, RCTs. A total 26 articles 1811 were included this review. On basis findings, particular components Mediterranean protein, omega-3 polyunsaturated fatty acids, vegetables, appear have beneficial application beneficial. However, long-term follow-up studies are still needed examine patient population.

Language: Английский

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Targeting the Hallmarks of Aging with Vitamin D: Starting to Decode the Myth

Published: Feb. 6, 2024

Aging is the results of several complex and multifactorial processes, where agents contribute to increase intrinsic vulnerability susceptibility age-related diseases. The hallmarks aging are a set biological mechanisms, finely regulated strictly interconnected, initiating or contributing changes anticipating network cellular intercellular connections between might represent possible target for research with pleiotropic affects. Vitamin D (VitD) known have positive impact not only on muscle bone health, but also extra-skeletal districts, due widespread presence VDRs (VDR). VitD VDR could be molecules potentially targeting hallmark network. To date, evidence about potential effect scarce in humans mainly based preclinical models. Although underpowered heterogeneous, in-human studies seems confirm modulatory some However, more investigations needed clarify effects its aging, hopefully highlighting courses translational applications clinical conclusions.

Language: Английский

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Targeting the Hallmarks of Aging with Vitamin D: Starting to Decode the Myth

Nutrients, Journal Year: 2024, Volume and Issue: 16(6), P. 906 - 906

Published: March 21, 2024

Aging is the result of several complex and multifactorial processes, where agents contribute to an increased intrinsic vulnerability susceptibility age-related diseases. The hallmarks aging are a set biological mechanisms that finely regulated strictly interconnected, initiating or contributing changes anticipating network cellular intercellular connections between might represent possible target for research with pleiotropic effects. Vitamin D (VitD) known have positive impact not only on muscle bone health but also extra-skeletal districts, due widespread presence Receptors (VDRs). VitD VDR could be molecules potentially targeting network. To date, evidence about potential effects scarce in humans mainly based preclinical models. Although underpowered heterogeneous, in-human studies seem confirm modulatory effect some However, more investigations needed clarify its hallmark aging, hopefully highlighting courses translational applications clinical conclusions.

Language: Английский

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Intelligent Rapid Detection Techniques for Low-Content Components in Fruits and Vegetables: A Comprehensive Review

Foods, Journal Year: 2024, Volume and Issue: 13(7), P. 1116 - 1116

Published: April 6, 2024

Fruits and vegetables are an important part of our daily diet contain low-content components that crucial for health. Detecting these accurately is paramount significance. However, traditional detection methods face challenges such as complex sample processing, slow speed, the need highly skilled operators. These limitations fail to meet growing demand intelligent rapid in fruits vegetables. In recent years, significant progress has been made technology, particularly detecting high-content accurate remains a challenge gained considerable attention current research. This review paper aims explore analyze several techniques have extensively studied this purpose. include near-infrared spectroscopy, Raman laser-induced breakdown terahertz among others. provides detailed reports analyses application components. Furthermore, it offers prospective exploration their future development field. The goal contribute enhancement widespread adoption technology It expected will serve valuable reference researchers practitioners area.

Language: Английский

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