Chrononutrition and Cardiometabolic Health: An Overview of Epidemiological Evidence and Key Future Research Directions

Nutrients, Journal Year: 2024, Volume and Issue: 16(14), P. 2332 - 2332

Published: July 19, 2024

Chrononutrition is a rapidly evolving field of nutritional epidemiology that addresses the complex relationship between temporal eating patterns, circadian rhythms, and metabolic health, but most prior research has focused on cardiometabolic consequences time-restricted feeding intermittent fasting. The purpose this topical review to summarize epidemiological evidence from observational intervention studies regarding role chrononutrition metrics related timing regularity in health preservation cardiovascular disease prevention. Observational are limited due lack time-stamped diet data population-based studies. Findings cohort generally indicate breakfast skipping or later first occasion, lunch dinner, greater proportion caloric intake consumed evening associated with adverse outcomes, including higher risk for coronary heart disease, hypertension, type 2 diabetes, obesity, dyslipidemia, systemic inflammation. Randomized controlled trials also limited, as focus feeding. Overall, interventions shift patterns earlier day restrict tend have protective effects small sample sizes short follow-up notable limitations. Innovation dietary assessment approaches, develop low-cost validated tools acceptable participant burden reliably capture metrics, needed advancing evidence. Culturally responsive pragmatic sufficiently large representative samples understand impact fixed schedules health. Additional warranted modifiable determinants investigate context other dimensions (quantity, quality, food nutrition security) achieving equity, elucidate underlying physiological mechanisms.

Language: Английский

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Nutritional profile of the diet according to circadian clock genes in the European Prospective Investigation into Cancer and Nutrition (EPIC) chronodiet study

Clinical Nutrition, Journal Year: 2025, Volume and Issue: 49, P. 165 - 177

Published: April 25, 2025

Circadian rhythms seem to impact both dietary intake and metabolism, depending on the individual's chronotype. We aimed explore whether nutritional composition of meals throughout day is influenced by genetics linked circadian clock chronotype within "European Prospective Investigation into Cancer Nutrition (EPIC) chronodiet" study. The study population comprised 3,183 subjects with information diet twelve genetic variants six genes (PER1, PER2, PER3, CRY1, NR1D1, CLOCK). associations between chrononutrition variables (macronutrients serving sizes each meal) were evaluated using linear regression, considering an additive model, adjusting for sex, age center, among others. β coefficients, 95 % confidence intervals (CI), p-values corrected multiple comparisons estimated. A risk score (GRS) that was associated evening/late as well overweight/obesity in a previous study, chronotype-GRS, tested its association variables. profile differed according chronotype, chronotypes exhibiting unbalanced during breakfast dinner compared intermediate early (e.g., percentage fats consumed at relative total fat intake: 13 9 %, respectively). However, significant differences not encountered chronotype-GRS. In multivariate analyses, individual nutrients revealed some nominal rs1801260 rs2070062 carbohydrates breakfast: = -0.06 0.08). Higher scorings chronotype-GRS inversely proteins (β -0.46 -0.41; p-value<0.006; 0.25) breakfast. Also, there inverse breakfast's portion size -0.3; p-value 0.03; 0.1). Genetic susceptibility evening-like prone seems be smaller breakfast, lower protein carbohydrate content.

Language: Английский

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Social jet lag is associated with core symptoms in 2-3-year-old children with autism spectrum disorders

Frontiers in Psychiatry, Journal Year: 2025, Volume and Issue: 16

Published: May 16, 2025

Background Social jet lag (SJL) is a form of circadian rhythm misalignment caused by the mismatch between social schedules and biological clocks, which associated with cognition, behavior, emotion in children. However, among children autism spectrum disorders (ASD) its impacts are unknown. Methods This cross-sectional study recruited 2-7-year-old ASD from special education institutions outpatient clinics. The Children’s Sleep Habits Questionnaire (CSHQ) assessed children’s sleep. SJL was calculated as |weekend sleep midpoint - weekday midpoint|. adequacy determined based on National Foundation’s recommendations. Core symptoms were evaluated using Childhood Autism Rating Scale (CARS), Responsiveness (SRS), Behavior Checklist (ABC). Developmental level Gesell Scale. Results 1) prevalence problems 49.8% mean CSHQ total score 48.04 ASD. There significant differences patterns weekends weekdays, characterized later bedtimes, delayed wake-up times, increased duration, reduced deficiency during weekends. 2) 2-3-year-old group had highest rates insufficiency (80.77% weekdays; 82.17% weekends). no duration across different age groups, median ranging 9.5 to 10 hours. 3) Median each 0.25 h (2–3 years), 0.5 (3–4 0.42 (4–5 (≥5 respectively. In aged 2–3 years, significantly positively correlated core 4) observed be weakly developmental personal-social only ≥ 3-year-old ( r = 0.100, P 0.042). Conclusion Our found for first time correlation finding suggests that may have potentially negative impact Therefore, it crucial emphasize importance regular routines ASD, especially younger

Language: Английский

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Host genetics and nutrition

Advances in genetics, Journal Year: 2024, Volume and Issue: unknown, P. 199 - 235

Published: Jan. 1, 2024

Language: Английский

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The influence of sleep on human taste function and perception: A systematic review

Journal of Sleep Research, Journal Year: 2024, Volume and Issue: unknown

Published: June 18, 2024

Summary Sleep problems are associated with increased risk of obesity. Multiple mechanisms have been identified to support this relationship, including changes in sensory processing and food choice. Taste researchers recently begun explore whether taste occur as a result short‐term or long‐term sleep habits. A systematic review was conducted investigate these relationships. total 13 studies were included the review. Heterogeneity both measurements used noted, most failed assess sour, bitter umami tastes. Still, available evidence suggests that sweet hedonic perception appears be undesirably influenced by short when viewed through lens health. That is, preferred sweetness concentration increases duration decreases. Habitual interventions curtailing had minimal associations effects on sensitivity. Salt sensitivity responses appear relatively unaffected insufficient sleep, but more work is needed. Solid other qualities not at present time.

Language: Английский

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DETERMINANTES DO COMPORTAMENTO ALIMENTAR EM ADULTOS OBESOS: UMA REVISÃO INTEGRATIVA

Hygeia - Revista Brasileira de Geografia Médica e da Saúde, Journal Year: 2024, Volume and Issue: 20, P. e2057 - e2057

Published: July 12, 2024

Objetivo: Realizar uma revisão integrativa acerca das publicações que abordem os determinantes do comportamento alimentar em adultos obesos. Metodologia: Trata-se de literatura. Esse estudo foi desenvolvido através etapas (1) definição tema e dos procedimentos obtenção descritores palavras chaves, (2) critérios inclusão exclusão da produção científica, (3) seleção elementos a serem extraídos, (4) análise interpretação resultados, (5) discussão (6) conclusão. Resultados: Os identificados para comportamentos alimentares obesos incluíram fatores como as escolhas alimentares, alimentação emocional, qualidade dieta, renda, escolaridade ocupação profissional. Discussão: Ao analisar o status socioeconômico, resultados deste evidenciaram predomínio obesidade indivíduos com menor nível sendo variável baixa predominante entre achados Conclusão: O analisado abrange série pesquisas enfatizam importância no tratamento obesidade.

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Association between CLOCK gene polymorphisms with circadian rhythm, chrononutrition, dietary intake, and metabolic parameters in adolescents

Frontiers in Public Health, Journal Year: 2024, Volume and Issue: 12

Published: Dec. 18, 2024

Circadian Locomotor Output Cycles Kaput (CLOCK) is one of the transcription factors from positive end molecular clock and regulates biological rhythm in mammals. Studies have shown that genetic variations CLOCK genes are associated with chronotype, sleep patterns, obesity, dietary energy, nutrient consumption. Although interest field chrononutrition continues to increase, investigations into temporal aspects habits adolescents notably limited. This study aims investigate relationship between rs3749474, rs4580704, rs1801260 polymorphisms circadian rhythm, metabolic parameters along adolescents.

Language: Английский

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The Use of Chrono Nutrition in Precision Nutrition

Precision Nutrition, Journal Year: 2023, Volume and Issue: unknown, P. 43 - 60

Published: Oct. 27, 2023

Precision Nutrition is an approach that involves tailoring dietary recommendations to individual's unique genetic, microbiome, lifestyle, and environmental factors. One aspect of has received increasing attention in recent years the role Chrono nutrition, which synchronizing intake with body's circadian rhythm. This chapter will provide overview principles nutrition its potential applications Nutrition. It explore evidence supporting using improve health outcomes prevent chronic diseases challenges associated implementing it practice.

Language: Английский

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