Current Topic in Lactic Acid Bacteria and Probiotics,
Journal Year:
2023,
Volume and Issue:
9(1), P. 1 - 8
Published: June 1, 2023
Exposure
to
lipopolysaccharide
(LPS)
causes
cognitive
impairment
(CI).
In
the
preliminary
study,
Lactobacillus
gasseri
NK109
suppressed
LPS-induced
expression
of
proinflammatory
cytokines
in
macrophages.
Therefore,
effect
on
LPS-increased
CI
was
investigated
mice.
Intraperitoneal
injection
LPS
caused
CI-like
behaviors
and
neuroinflammation.
However,
orally
administered
reduced
hippocampal
IL-1β
TNF-α
expression,
whereas
LPS-decreased
BDNF
increased.
also
colonic
myeloperoxidase,
IL-1β,
expression.
The
efficacy
increased
by
combination
soybean
embryo
ethanol
extract
(SE).
These
findings
suggest
that
with
SE
can
improve
alleviating
inflammation-mediated
thereby
being
beneficial
for
dementia
therapy.
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(16), P. 2736 - 2736
Published: Aug. 16, 2024
Soybean
alleviates
cognitive
impairment.
In
our
preparatory
experiment,
we
found
that
dry-heat
(90
°C
for
30
min)-processed
soybean
embryo
ethanol
extract
(hSE)
most
potently
suppressed
lipopolysaccharide
(LPS)-induced
tumor
necrosis
factor
(TNF)-α
expression
in
BV2
cells
among
dry-heat-,
steaming-,
and
oil
exclusion-processed
extracts
(SEs).
Heat
processing
increased
the
absorbable
soyasaponin
Bb
content
of
SE.
Therefore,
investigated
whether
hSE
its
supplement
could
mitigate
LPS-impaired
function
mice.
Among
SEs,
mitigated
more
than
parental
upregulated
LPS-suppressed
brain-derived
neurotropic
(BDNF)
hippocampus,
while
LPS-induced
TNF-α
IL-1β
hippocampus
colon
were
downregulated.
Lactobacillus
gasseri
NK109
additively
function-enhancing
activity
mice
with
impairment
as
follows:
mix
hippocampal
BDNF
BDNF-positive
neuron
cell
numbers
decreased
NF-κB-positive
colon.
These
findings
suggest
may
decrease
colitis
neuroinflammation
by
suppressing
NF-κB
activation
inducing
expression,
resulting
attenuation
Biomarkers,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 9
Published: Nov. 1, 2024
The
age-induced
disruption
of
gut
flora,
termed
dysbiosis,
is
intimately
tied
to
compromised
immune
function,
augmented
oxidative
stress,
and
a
spectrum
age-linked
disorders.
This
review
examines
the
fundamental
mechanisms
employed
by
probiotic
strains
modulate
microbiota
composition
metabolic
profiles,
mitigate
cognitive
decline
via
gut-brain
axis,
gene
transcription,
alleviate
inflammatory
responses
stress.
We
elucidate
capacity
probiotics
as
precision
intervention
restore
microbiome
homeostasis
age-related
conditions,
thereby
offering
theoretical
framework
for
decelerate
aging,
manage
diseases,
elevate
quality
life.
Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 12, 2024
AbstractSaccharomyces
boulardii
(Sb),
a
yeast
probiotic,
has
beneficial
effects
on
gastrointestinal
and
metabolic
diseases.
Recently,
the
manipulation
of
gut
microbiota
with
Sb
its
potential
role
in
modulating
neurological
conditions
through
regulating
neuroinflammatory
responses
via
gut-brain
axis
been
considered.
In
this
study,
we
examined
effect
toll-like
receptors
4
(TLR4)-mediated
neuroinflammation
spatial
memory
impairment
lipopolysaccharide
(LPS)
model.
The
allocation
rats
into
four
groups,
namely
1)
control,
2)
LPS,
3)
+
4)
Sb,
was
done
randomly,
all
treatments
were
applied
according
to
experimental
design.
Memory
performance
then
evaluated
by
Morris
water
maze
(MWM)
task.
levels
TLR4
pathway-mediated
proteins
brain-derived
neurotrophic
factor
(BDNF)
hippocampus
determined
using
western
blot.
Also,
neuronal
survival
investigated
Nissl
staining
anatomical
area
brain.
Results
demonstrated
that
oral
supplementation
improved
ameliorating
LPS-induced
deficit
rats.
Regarding
markers,
elevated
nuclear
kappa
B
(NF-κB)
interleukin
(IL)-1β
significantly
decreased
brains
groups
following
treatment
Sb.
Meanwhile,
destructive
LPS
reduced
hippocampal
CA1
CA3
regions.
Overall,
our
findings
suggest
may
have
impact
preventing
processes
mediated
TLR4/NF-κB
axis.
Current Topic in Lactic Acid Bacteria and Probiotics,
Journal Year:
2023,
Volume and Issue:
9(1), P. 1 - 8
Published: June 1, 2023
Exposure
to
lipopolysaccharide
(LPS)
causes
cognitive
impairment
(CI).
In
the
preliminary
study,
Lactobacillus
gasseri
NK109
suppressed
LPS-induced
expression
of
proinflammatory
cytokines
in
macrophages.
Therefore,
effect
on
LPS-increased
CI
was
investigated
mice.
Intraperitoneal
injection
LPS
caused
CI-like
behaviors
and
neuroinflammation.
However,
orally
administered
reduced
hippocampal
IL-1β
TNF-α
expression,
whereas
LPS-decreased
BDNF
increased.
also
colonic
myeloperoxidase,
IL-1β,
expression.
The
efficacy
increased
by
combination
soybean
embryo
ethanol
extract
(SE).
These
findings
suggest
that
with
SE
can
improve
alleviating
inflammation-mediated
thereby
being
beneficial
for
dementia
therapy.
